Determination of rutin deca(H-) sulfate sodium in rat plasma using ion-pairing liquid chromatography after ion-pairing solid-phase extraction

Emerging Sulfated Flavonoids and other Polyphenols as Drugs: Nature as an Inspiration

“…The stability of rutin persulfate ( 18 ) in plasma under various conditions (at 1.2 and 6 nmol/mL; 24 hr at room temperature and 4 weeks at ‒20°C) showed that compound 18 was stable with detectable concentrations of at least 93% of the initial concentration . The stabilities of resveratrol and resveratrol 4′‐sulfate ( 74 ) were investigated for 24 hr at 37°C in RPMI 1640 cell culture medium; whereas nonsulfated resveratrol degraded 50% under these conditions, and resveratrol 4′‐sulfate ( 74 ) was found stable during 24 hr .…”

“…Several parameters that characterize the distribution of sulfated flavonoids have been determined. For instance, the volume of distribution for rutin persulfate ( 18 ) after intravenous administration via caudal vein was shown to be 240 mL/kg . Rutin persulfate ( 18 ), the most advanced derivative in preclinical studies was shown to have a clearance value of 1.333 mL/min/kg and a short terminal half‐life (125 min) after intravenous administration via caudal vein .…”

Determination of 5α-androst-16-en-3α-ol in truffle fermentation broth by solid-phase extraction coupled with gas chromatography–flame ionization detector/electron impact mass spectrometry

“…Sample cleaning process is essential for complex mixture analysis, especial the nature products or biological samples. Comparing to TLC, solid-phase extraction (SPE) is widely used in sample extraction and clean up for aqueous samples, such as wine [16], waste water [17], plasma [18], etc. The application of SPE for the determination of androst-16-ene steroids in human testis [19], human urine [20], and boar [21][22] were also reported.…”

Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC–MS/MS

“…The analytical procedure was successfully applied to pharmacokinetic study of the analytes after oral administration of Fructus Sophorae extract. Additionally, the results from this study demonstrated that the pharmacokinetic behavior of the six flavones in Fructus Sophorae was quite different from their pure forms or in other extracts [16][17][18][19][20]. The information described above might be helpful for further studies on the pharmacokinetics of Fructus Sophorae and may be beneficial for the application of clinical therapy.…”