Quantitative determination of Nε-(carboxymethyl)lysine in sterilized milk by isotope dilution UPLC-MS/MS method without derivatization and ion pair reagents

Chen, Qin; Li, Ying; Dong, Lezhen; Shi, Ranran; Wu, Zhen; Liu, Lianliang; Zhang, Jingshun; Wu, Zufang; Pan, Daodong

doi:10.1016/j.foodchem.2022.132697

Cited by 27 publications

(13 citation statements)

References 34 publications

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“…Recently, Chen et al reported a study for quantitative determination of N ε -(carboxymethyl)lysine (CML) through ultraperformance liquid chromatography tandem mass spectrometry (UPLC−MS/MS). 160 It is quantitatively accurate and operable, so it could be used for daily monitoring. A similar method can be utilized for synthesizing glucose-responsive hydrogels for insulin detection and release.…”

Section: Magnetic-responsivementioning

confidence: 99%

“…It is more convenient for glucose-responsive hydrogel to treat diabetes without frequent insulin injections when blood glucose levels rise since insulin will be released from the hydrogel as the level increases. Recently, Chen et al reported a study for quantitative determination of N ε -(carboxymethyl)lysine (CML) through ultraperformance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) . It is quantitatively accurate and operable, so it could be used for daily monitoring.…”

Section: Stimuli-responsivenessmentioning

confidence: 99%

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Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Srivastava

Choudhury

2022

Ind. Eng. Chem. Res.

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Hydrogels are a soft material that undergoes cross-linking between polymers to form a hydrophilic three-dimensional network. In fact, similarity to body tissue, soft consistency, biocompatibility, and elasticity, impart a protagonic role of hydrogel to be applied as a biomaterial. In response to external cues, stimuli-responsive hydrogels are particularly impactful, enabling remarkable levels of control over material properties. They can endure changes in swelling behavior, permeability, network structure, and mechanical strength. Nevertheless, such changes induce single-cycle or reversible transitions, so hydrogels can regain their initial state once the trigger is removed. Recently, polysaccharide-based hydrogels with stimuli-responsive properties resulted in developing biomimetic structures for a widespread biotechnological application owing to their excellent biodegradability, biocompatibility, nonimmunogenicity, functional properties, ease of gelation, and derivatization. This review will initially highlight recent advances in cross-linking methods and chemistry for preparing stimuli-responsive hydrogels. Subsequently, state-of-the-art techniques to understand the structural, chemical, and rheological behavior of polysaccharide-based stimuli-responsive hydrogel will be discussed. Additionally, the responsiveness of polysaccharide hydrogel toward diverse stimuli such as redox, temperature, light, pH, magnetism, electricity, etc., with a broad spectrum of applications will be described in detail. This review also attempts to address the lacunae of existing stimuli-responsive hydrogel and their future perspectives.

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Section: Magnetic-responsivementioning

confidence: 99%

Section: Stimuli-responsivenessmentioning

confidence: 99%

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Srivastava

Choudhury

2022

Ind. Eng. Chem. Res.

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“…Advanced glycation end products (AGEs) generated from the Maillard reaction are highly implicated in deleterious health effects such as cardiovascular diseases, diabetes, Alzheimer’s disease, schizophrenia, and breast cancer (BrCa). − Moreover, only about 30% of AGEs could be eliminated within 2 days for a healthy body, and, for patients with chronic diseases, it reaches less than 5% . Industrial processed and home-cooked foods are in charge of exogenous exposure to AGEs, especially the inevitable sterilization and storage process of dairy products .…”

Section: Introductionmentioning

confidence: 99%

Magnetically Controlled Nanorobots Based on Red Emissive Peptide Dots and Artificial Antibodies for Specific Recognition and Smart Scavenging of N^ε-(Carboxymethyl)lysine in Dairy Products

Yuan

et al. 2023

J. Agric. Food Chem.

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Food-borne advanced glycation end products (AGEs) are highly related to various irreversible diseases, and N ε-(carboxymethyl)lysine (CML) is the typical hazardous AGE. The development of feasible strategies to monitor and reduce CML exposure has become desirable to address the problems. In this work, we proposed magnetically controlled nanorobots by integrating an optosensing platform with specific recognition and binding capability, realizing specific anchoring and accurate determination as well as efficient scavenging of CML in dairy products. The artificial antibodies offered CML imprinted cavities for highly selective absorption, and the optosensing strategy was designed based on electron transfer from red emissive self-assembling peptide dots (r-SAPDs) to CML, which was responsible for the identity, response, and loading process. The r-SAPDs overcame the interference from autofluorescence, and the limit of detection was 0.29 μg L–1, which bestowed accuracy and reliability for in situ monitoring. The selective binding process was accomplished within 20 min with an adsorption capacity of 23.2 mg g–1. Through an external magnetic field, CML-loaded nanorobots were oriented, moved, and separated from the matrix, which enabled their scavenging effects and reusability. The fast stimuli-responsive performance and recyclability of the nanorobots provided a versatility strategy for effective detection and control of hazards in food.

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“…Compared with traditional HPLC, UPLC can separate target compounds more quickly and sensitively by increasing column pressure. 25,26 Also, UPLC-MS/MS can also accurately recognize and quantify aimed compounds in samples by the multireaction monitoring model, which can screen the specific excimer ion/characteristic fragment ion pair combination. This significantly improves the accuracy and sensitivity of the analysis and has a lower detection limit.…”

Section: ■ Introductionmentioning

confidence: 99%

“…In recent years, UPLC-MS/MS has become a new and potential detection technology. Compared with traditional HPLC, UPLC can separate target compounds more quickly and sensitively by increasing column pressure. , Also, UPLC-MS/MS can also accurately recognize and quantify aimed compounds in samples by the multireaction monitoring model, which can screen the specific excimer ion/characteristic fragment ion pair combination. This significantly improves the accuracy and sensitivity of the analysis and has a lower detection limit. − It is worth noting that using UPLC-MS/MS as a detection method, combined with other technologies, is becoming a new research strategy.…”

Section: Introductionmentioning

confidence: 99%

Quick and In Situ Detection of Different Polar Allelochemicals in Taxus Soil by Microdialysis Combined with UPLC-MS/MS

Qiao

Nie

et al. 2022

J. Agric. Food Chem.

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The action of allelopathy need that allelochemicals exist in the soil and reach a certain concentration. Also, the detection of allelochemicals in the soil is one of the most important research topics in the process of exploring allelopathy. To solve the problem of the simultaneous detection of allelochemicals with low concentrations and different polarities, a novel strategy for the quick detection of the allelochemicals in Taxus soil by microdialysis combined with UPLC-MS/MS on the basis of in situ detection without destroying the original structure of soil was developed for the first time in the work. The dialysis conditions were optimized by the Box–Behnken design (BBD): 70% methanol, 3 μL/min flow rate, and 3 cm long membrane tube. A reliable UPLC-MS/MS program was systematically optimized for the simultaneous detection of nine allelochemicals with different polarities. The results proved the differences in the contents and distributions of nine allelochemicals in three different Taxus soils.

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Quantitative determination of Nε-(carboxymethyl)lysine in sterilized milk by isotope dilution UPLC-MS/MS method without derivatization and ion pair reagents

Cited by 27 publications

References 34 publications

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Magnetically Controlled Nanorobots Based on Red Emissive Peptide Dots and Artificial Antibodies for Specific Recognition and Smart Scavenging of N^ε-(Carboxymethyl)lysine in Dairy Products

Quick and In Situ Detection of Different Polar Allelochemicals in Taxus Soil by Microdialysis Combined with UPLC-MS/MS

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Quantitative determination of Nε-(carboxymethyl)lysine in sterilized milk by isotope dilution UPLC-MS/MS method without derivatization and ion pair reagents

Cited by 27 publications

References 34 publications

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Stimuli-Responsive Polysaccharide-Based Smart Hydrogels and Their Emerging Applications

Magnetically Controlled Nanorobots Based on Red Emissive Peptide Dots and Artificial Antibodies for Specific Recognition and Smart Scavenging of Nε-(Carboxymethyl)lysine in Dairy Products

Quick and In Situ Detection of Different Polar Allelochemicals in Taxus Soil by Microdialysis Combined with UPLC-MS/MS

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Product

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Magnetically Controlled Nanorobots Based on Red Emissive Peptide Dots and Artificial Antibodies for Specific Recognition and Smart Scavenging of N^ε-(Carboxymethyl)lysine in Dairy Products