Quantitative determination of multi-class bioactive constituents for quality control of Yiqi Jiangzhi Granules

Guo, Shao-Bo; Hu, Shaowei; Jiang, Lijuan; Chen, Xiaohe; Zhang, Wei; Jiang, Yanyan; Liu, Bin

doi:10.1016/j.chmed.2022.03.001

Cited by 4 publications

(2 citation statements)

References 10 publications

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“…Additionally, ethnic medicine reveals intricate patterns of “multiple medicines from a single plant” and “one medicine from multiple botanical sources” [ 6 , 7 ]. Consequently, finding a “Rosetta stone” to improve the quality of medicinal materials is a challenging task, especially with the increasing demand for efficacy and safety [ [8] , [9] , [10] ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Yang,

Sima,

Luo

et al. 2024

Journal of Pharmaceutical Analysis

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Section: Introductionmentioning

confidence: 99%

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Yang,

Sima,

Luo

et al. 2024

Journal of Pharmaceutical Analysis

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“…Generally, the HPLC method is used to analyze its content. With the development of mass spectrometry (MS) technology, the determination accuracy and sensitivity are greatly improved (Cheng et al, 2021; Guo et al, 2022; Rakotondrabe et al, 2023; Yan et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Determination of Four Chemical Components in Qishen Yiqi Dripping Pills by UPLC-MS/MS Method

Lili,

Honglian,

Yanxia

et al. 2023

Pharmacognosy Magazine

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Background In this study, the ultrahigh performance liquid chromatography mass spectrometry/mass spectrometry (UPLC-MS/MS) method was established to test the contents of protocatechuic acid (C7H6O4), salvianolic acid B (C36H30O16), rosmarinic acid (C19H14O3), and cryptotanshinone (C19H20O3) in Qishen Yiqi dripping pills. Materials and Methods Methanol was chosen as the solvent according to a certain material–liquid ratio as a solution, and the ultrasonic extraction method was used to prepare the sample solution. UPLC-MS/MS was used to complete a quantitative analysis of the contents of Qishen Yiqi dripping pills. Then, the chromatographic conditions were shown as follows. The stationary phase was Agilent ZORBAX SB-C18 (2.1 mm × 100 mm, 1.8 µm), and the mobile phase was acetonitrile–0.1% formic acid water. The column temperature was 40℃, the injection volume was 3 µL, and the flow rate was 0.2 mL⋅min–1. Finally, the determination method was built to test four chemical constituents under the multiple reaction monitoring (MRM) analysis mode. Results The retention times of protocatechuic acid, salvianolic acid B, rosmarinic acid, and cryptotanshinone were 1.26, 1.32, 1.35, and 6.76 min, respectively. In addition, the concentration ranges of four compounds were 0.25–2.0 µg⋅mL–1, 10.0–50.0 µg⋅mL–1, 5.0–50.0 µg⋅mL–1, and 1.0–10.0 µg⋅mL–1, respectively. And the standard curve showed a good linear relationship in a reasonable range ( r2 ≥ 0.9950). The average recovery rate was from 96% to 124%. The contents of protocatechuic acid, salvianolic acid B, rosmarinic acid, and cryptotanshinone were 0.12%–0.022%, 17%–8.4%, and 6.5%–8.6% in seven batches of Qishen Yiqi dripping pills, which were in the range of 23%–31%. The instrument ran stably, and the method had good accuracy and repeatability (relative standard deviation [RSD] ≤ 3%). Additionally, the test result was stable within 10 h. Conclusion The contents of the four constituents were different among different batches. The quantitative method was established to determine the four chemical components in Qishen Yiqi dripping pills, which could provide a reference for quality evaluation in vivo.

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Three-dimensional characteristic chromatogram by online comprehensive two-dimensional liquid chromatography: Application to the identification and differentiation of ginseng from herbal medicines to various Chinese patent medicines

Jiang

et al. 2023

Journal of Chromatography A

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Quantitative determination of multi-class bioactive constituents for quality control of Yiqi Jiangzhi Granules

Cited by 4 publications

References 10 publications

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Analysis of GC × GC fingerprints from medicinal materials using a novel contour detection algorithm: A case of Curcuma wenyujin

Determination of Four Chemical Components in Qishen Yiqi Dripping Pills by UPLC-MS/MS Method

Three-dimensional characteristic chromatogram by online comprehensive two-dimensional liquid chromatography: Application to the identification and differentiation of ginseng from herbal medicines to various Chinese patent medicines

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