Quantitative determination of Lisinopril Dihydrate in pharmaceutical preparations by direct potentiometriy

Abstract

A direct potentiometric titration method was applied for determination of Lisinopril Dihydrate. The method was based on the treatment of the primary data with nonlinear regression procedure. An accessible and easy-to-use algorithm for the evaluation (quantification) of a system with acid-base properties has been developed to provide a quick and unambiguous answer for the quantitative content of Lisinopril Dihydrate. The acid-base constants of Lisinopril Dihydrate were determined in aqueous solutions (at constant ionic strength 0.2 mol/l KCl and temperature 25°C). The potentiometric method developed was validated according to ICH and shows very good accuracy and precision. The present approach can be successfully used in routine analysis of the drug in quality control laboratories.

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“…They pose a special feature in treating patient with diabetes, slowing the development and progression of diabetic glomerulopathy. It is only available in the market as oral tablets despite its low systems bioavailability of 25 Several methods have been developed for the estimation of lisinopril using HPLC methods [7-9], UV-Vis [10-18], Chromatographic [19], LC-MS/MS [20], Potentiometriy [21,22], Voltammetric [23], Spectrofluorometric [24,25], FT-IR [26,27], X-Ray [28] and Polarographic [29]. This research aims to use a sensitive and accurate spectrophotometric method using the derivative to estimate lisinopril in its pure form and the pharmaceutical formulations in the presence of the drug losartan, which is close to it in the spectrum; it is not possible to use other more accurate and sensitive methods for its estimation.…”