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Abstract

A simple, sensitive method for simultaneous quantifying of lisinopril in the presence of losartan in its pure form and pharmaceutical formulations in tablet form by using UV-Vis spectrophotometric. This method depends on the first spectrum derivative utilization zero intersection, the summit to foundation line, and the summit of area measurement. A Linearity was used for a range of drugs, lisinopril concentrations 2-16 µg/mL and losartan concentrations 2-14 µg/mL in the mixture. The correlation coefficients of lisinopril in the presence of losartan (8 μg/mL) using peak to baseline 0.9980, 0.99674, and peak area 0.99944 but the correlation coefficients of losartan in the presence of lisinopril 6 μg/mL utilization peak to baseline 0.9997, 0.9984, 0.9994 and peak area 0.9972, 0.9952. The limits of detection (LOD) of 0.0125 µg/mL for lisinopril and losartan were measured by this method. Determination of precision and accuracy by measuring Relative Standard Deviation (RSD %) whose value is less than 4 % and Recovery% (Rec. %) of acceptable value. The method showed success in the direct estimation of each of the two drugs, lisinopril and losartan, in the presence of the other in pure form and pharmaceutical formulations in tablet form.