Quantitative Determination of Guaifenesin, Phenylprolamine Hydrochloride Sodium Benzoate Δ Codeine Phosphate in Cough Syrups by High-Pressure Liquid Chromatography

Voltammetric assay of Guaifenesin in pharmaceutical formulation

“…Guaifenesin is used to treat symptoms of allergy, colds and upper respiratory infections. Several methods are reported in the literature proposing fast and reliable techniques for the determination of Guaifenesin in various cough-cold formulations [1][2][3][4][5][6][7]. Most of the methods reported for the analysis of Guaifenesin in different matrices, alone or with other active substances, rely on the use of chromatographic techniques.…”

Simultaneous, stability indicating, HPLC-DAD determination of guaifenesin and methyl and propyl-parabens in cough syrup

“…in solid and liquid formulations [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]. Moreover some of these methods showed quantitative determination of the preservative sodium benzoate [2,3,7,[9][10][11].…”

“…Moreover some of these methods showed quantitative determination of the preservative sodium benzoate [2,3,7,[9][10][11]. Similarly in current USP monographs [18], GUA was determined by HPLC either individually or in combination with other drugs as pseudoephedrine, codeine, and dextromethorphan.…”

Quantitation of Guaifenesin (Glyceryl Guaiacolate) in Syrup and Spiked Human Plasma using HPLC with Diode Array Detection

“…Several liquid chromatographic methods in relation to guaifenesin have been reported in the literature. There are several quantitative HPLC analysis methods for pharmaceutical preparations containing guaifenesin with two, three or five other active ingredients [4][5][6][7][8][9], cold syrups [10][11][12][13][14][15][16][17][18] and in human plasma [19][20][21][22][23][24]. Two HPLC quantitative analysis studies have seen for human and animal plasma containing only guaifenesin [25,26].…”