Abstract:A new, simple and rapid reverse phase-high performance liquid chromatography-diode array detection (RP-HPLC-DAD) method has been developed using sibutramin (S) as internal standard for quantitative determination of guaifenesin (G) and validated both in syrup dosage forms and spiked human plasma samples. The analysis was carried out within 10 min on Inertsil C18 column using isocratic mobile phase consists of phosphate buffer and methanol with pH 3 (60:40, v/v) at a flow-rate of 1 mL min -1 and detection at 212… Show more
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