Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: A multi-level, single-sample approach

Evaluation of Five Antischizophrenic Agents Against Toxoplasma gondii in Human Cell Cultures

“…Thioridazine has also been administered to a pregnant woman without adverse effects to the baby (Yaris et al, 2004). We found thioridazine is slightly more potent than fluphenazine against T. gondii in cell culture, and because therapeutic plasma levels of thioridazine are in the range of 5 mM (Kirchherr and Kuhn-Velten, 2006), drug levels in patients undergoing treatment with thioridazine are more than sufficient to exert an anti-T. gondii activity.…”

Pharmacogenetics and olanzapine treatment: CYP1A2*1F and serotonergic polymorphisms influence therapeutic outcome

“…Steady-state serum samples (after at least 1 week at a fixed olanzapine dose, 12-14 h postdose in week 4 of olanzapine treatment) were available for 73 patients and were measured by tandem mass spectrometry (LC/MS/MS) modified from Kirchherr et al 54 with a LLOQ of 2.5 ng ml À1 . Commercial control samples (Chromsystems GmbH, München, Germany) containing 29 or 101 ng ml À1 were found to be 100 ± 8%.…”

Two Selective Spectrophotometry Methods for the Determination of Thioridazine Hydrochloride in Tablets and in Biological Fluids

“…Among the methods, voltammetry [8][9][10] and conventional high performance liquid chromatography 11,12 are most often used. Supercritical fluid chromatography 13 and HPLC combined with other techniques [14][15][16][17][18] were reported for determination of TRH and its main metabolites or derivatives. Chemiluminescence 19 , electrophoresis 20 , spectrofluorimetric 21,22 and spectrophotometry [23][24][25][26] have been also reported for the determination of thioridazine hydrochloride.…”