Quantitative determination of diol metabolites of CS-670, a new antiinflammatory agent, by capillary column gas chromatography-mass spectrometry

Development and validation of an LC-MS/MS method for the determination of pelubiprofen and its active metabolite, trans-alcohol, in human plasma and its application to pharmacokinetic study

“…As one or two asymmetric centers are generated by this reduction, it has many stereoisomers. In particular, unsaturated-(M-B) and trans-alcohol (M-D) were found to be active metabolites in vitro studies of prostaglandin synthesis [8,9], which means that the active metabolites of pelubiprofen should be determined to estimate pharmacological effects. Several analytical methods have been reported for the determination of pelubiprofen and its metabolites.…”

“…Several analytical methods have been reported for the determination of pelubiprofen and its metabolites. However, these methods include chiral HPLC with antibody-mediated extraction [10] and GC-MS [9,11], and thus, they are not convenient for analyzing the large numbers of human samples generated during pharmacokinetic studies because of the laborious sample pretreatment [9][10][11], no human bio-sample [9], and the large amount of plasma required [10]. Furthermore, to our knowledge, no study has been previously performed on pelubiprofen and M-D simultaneous determination in human plasma http://dx.doi.org/10.1016/j.jchromb.2014.12.037 1570-0232/© 2015 Elsevier B.V. All rights reserved.…”

Water Stable Boronic Acid Grafted Barium Metal–Organic Framework for the Selective Adsorption of cis-Diols

“…They have numerous functional roles in biological systems, such as in the human and animal body, and are essential for the existence of life on earth. , The low abundance of cis -diol-containing molecules demands their isolation and separation before a successful analysis . There are many methods for the study of cis -diols, important ones being high-performance liquid chromatography (HPLC), gas chromatography (GC), and capillary zone electrophoresis (CZE); however, the enrichment techniques which are cardinal in determining the competence of the study are very few. Adsorption is at the top of the list of concentration methods where the adsorbent plays a crucial role .…”