Quantitative determination of 20-hydroxyecdysone in methanolic extract of twigs from Vitex polygama Cham.

Gallo, Margareth Borges Coutinho; Beltrame, Flávio Luís; Vieira, Paulo C.; Cass, Quézia B.; Fernandes, João B.; Silva, Maria Fátima das Graças Fernandes da

doi:10.1016/j.jchromb.2005.12.006

Cited by 12 publications

(6 citation statements)

References 16 publications

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“…20‐hydroxyecdysone ( 9 ; C 27 H 44 O 7 ): amorphous colorless solid; ESI/MS m / z 479 [M − H] − ; 13 C NMR (50 MHz, deuteropyridine): δ 38.1 (C‐1); 68.5 (C‐2); 68.3 (C‐3); 32.7 (C‐4); 51.6 (C‐5); 204.1 (C‐6); 121.9 (C‐7); 166.6 (C‐8); 34.7 (C‐9); 38.9 (C‐10); 21.4 (C‐11); 32.3 (C‐12); 48.4 (C‐13); 84.5 (C‐14); 31.9 (C‐15); 21.7 (C‐16); 50.4 (C‐17); 18.2 (C‐18); 24.7 (C‐19); 77.2 (C‐20); 21.9 (C‐21); 77.9 (C‐22); 27.7 (C‐23); 42.8 (C‐24); 70.1 (C‐25); 30.4 (C‐26); 30.1 (C‐27); UV and 1 H NMR data were identical to data previously reported 27. Polypodine B ( 10 ; C 27 H 44 O 8 ); stachysterone ( 11 ; C 27 H 42 O 6 ) and shidasterone ( 12 ; C 27 H 42 O 6 ).…”

Section: Resultssupporting

confidence: 82%

Bioactivity of extracts and isolated compounds from Vitex polygama (Verbenaceae) and Siphoneugena densiflora (Myrtaceae) against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Gallo

Rocha

Cunha

et al. 2006

Pest Management Science

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The effects of crude extracts, fractions and isolated compounds from Vitex polygama Cham. and Siphoneugena densiflora Berg were evaluated on the development of Spodoptera frugiperda JE Smith, a destructive insect pest of corn and several other crops. The extracts and fractions were incorporated into an artificial diet at 1 mg g(-1) and offered to the insect during its larval stage. Length and viability of larval and pupal stages as well as pupal weight were assessed. Isolated compounds were tested through superficial contamination of the diet at 0.1 mg g(-1). Weight and viability of ten-day-old larvae were determined. Methanolic and hydroalcoholic S. densiflora extracts caused 100% larval mortality, while leaf and fruit hydroalcoholic extracts from V. polygama were the most active. Among the isolated compounds, flavonoids presented the best insecticidal results, and tannins the best larval growth inhibition.

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Section: Resultssupporting

confidence: 82%

Bioactivity of extracts and isolated compounds from Vitex polygama (Verbenaceae) and Siphoneugena densiflora (Myrtaceae) against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Gallo

Rocha

Cunha

et al. 2006

Pest Management Science

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“…Despite the fact that the genus is well represented in Brazil with c.a. 35 species (Leitão et al, 2008), as far as we know, only three species have been chemically or pharmacologically investigated so far (Leitão et al, 2008, Gallo et al, 20082006, Sá Barreto et al, 2005, Gonçalves et al, 2001. Vitex cymosa Bertero is a small tree widely distributed in the Central and Amazon regions of Brazil, where it is popularly known as "tarumã-do-igapó" and "tarumã-do-alagado" (Correa, 1926).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

Leitão¹,

Santos²,

Monachè³

et al. 2011

Rev. bras. farmacogn.

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Abstract:Vitex cymosa Bertero ex Spreng., Lamiaceae, is found in Central and Amazon regions of Brazil, where it is popularly used as antirheumatic. Extracts from the leaves of V. cymosa were tested in analgesia models such as abdominal contortions induced by acetic acid and formalin to test peripheral analgesia; as well as the tail flick and hot plate models, to test spinal and supraspinal analgesia. A significant reduction was observed in the number of contortions with all extracts and in all doses. In the formalin model, a reduction in the second phase (inflammatory) was observed with all extracts, whereas only the n-butanol extract was able to act in the first, neurogenic, phase. In the tail flick model, all extracts increased latency time. Naloxone treatment reverted analgesic effect of all extracts with the exception of the dichloromethane one. All extracts developed peripheral and central analgesic activity. In the hot plate model no antinociceptive effect was observed for all tested extracts. All these results taken together suggest that V. cymosa leaf extracts were able to promote peripheral and central antinociceptive activity mediated by the opioid system.Twenty three substances were isolated and identified in the extracts and include flavonoids (C-glucosyl flavones, flavones and flavonols), triterpene acids from ursane and oleanane types, iridoids (free and glucosides), as well as simple phenols.

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“…peduncularis: Suksamrarn et al, 2002]. These plants and their constituents have variously been cited for their effectiveness as antiinflammatory [e.g., Chawla et al, 1992], antibacterial [Sridhar et al, 2005], antidiarrheal [Agunu et al, 2005], antihistamine [Alam et al, 2002], analgesic [Dharmasiri et al, 2003], antiviral [Goncalves et al, 2001], antioxidant [Gallo et al, 2006], antitrypanosomal [Kiuchi et al, 2004], antifungal [Hernandez et al, 1999], anticonvulsant [Tandon & Gupta, 2005], cytotoxic [Hirobe et al, 1997], antiandrogenic [Das et al, 2004], insecticidal [Pushpalatha & Muthukrishnan, 1995], antivenin [Alam & Gomes, 2003], and profertility agents [Eckman & Hines, 1993]. The most widely cited effects are those of V. agnus-castus (VAC), the fruits of which are cited in both historical and modern usage for their impact on the reproductive physiology of one or both sexes [Daniele et al, 2005].…”

Section: Introductionmentioning

confidence: 99%

Hyperprogesteronemia in response to Vitex fischeri consumption in wild chimpanzees (Pan troglodytes schweinfurthii)

Thompson¹,

Wilson²,

Gobbo³

et al. 2008

American J Primatol

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Chimpanzees in Gombe National Park consume fruits of Vitex fischeri during a short annual fruiting season. This fruit species is a member of a genus widely studied for phytoestrogen composition and varied physiological effects. One particularly well-studied species, V. agnus-castus, is noted for its documented effects on female reproductive function, evidenced in increased progesterone levels and consequent regulation of luteal function. We examined reproductive hormone levels in both male and female chimpanzees during a 6-week period of intense V. fischeri consumption. V. fischeri consumption was associated with an abrupt and dramatic increase in urinary progesterone levels of female chimpanzees to levels far exceeding the normal range of variation. Female estrogen levels were not significantly impacted, nor were male testosterone levels. These are some of the first data indicating that phytochemicals in the natural diet of a primate can have significant impacts on the endocrine system, though the fluctuating nature of chimpanzee diet and reproductive function does not allow us to determine whether the effects observed during this short period had a broader positive or negative impact on female fertility. Given the widespread use of various Vitex species by African primates and the as-yet-undescribed phytochemical properties of these species, we predict that our observations may be indicative of a broader phenomenon.

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Quantitative determination of 20-hydroxyecdysone in methanolic extract of twigs from Vitex polygama Cham.

Cited by 12 publications

References 16 publications

Bioactivity of extracts and isolated compounds from Vitex polygama (Verbenaceae) and Siphoneugena densiflora (Myrtaceae) against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Bioactivity of extracts and isolated compounds from Vitex polygama (Verbenaceae) and Siphoneugena densiflora (Myrtaceae) against Spodoptera frugiperda (Lepidoptera: Noctuidae)

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

Hyperprogesteronemia in response to Vitex fischeri consumption in wild chimpanzees (Pan troglodytes schweinfurthii)

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