Quantitative detection of plasma-generated radicals in liquids by electron paramagnetic resonance spectroscopy

Tresp, Helena; Hammer, Malte U.; Winter, J.; Weltmann, Klaus‐Dieter; Reuter, Stephan

doi:10.1088/0022-3727/46/43/435401

Cited by 187 publications

(153 citation statements)

References 48 publications

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“…Plasma exposure times exceeding 60 s showed dose-dependent caspase 3 activation up to 80% (360 s). This is consistent with the findings of Barton et al, who showed that cytotoxicity increases in THP-1 monocytes after long plasma exposure [37]. Recently, Avisetti et al showed the connection of JNK and caspase 3 activation due to reactive oxygen species exposure, which may be responsible for the plasma-induced caspase 3 activation in the monocytes [20].…”

Section: Apoptosis Induction In Response To Plasma Treatmentsupporting

confidence: 89%

Non-thermal plasma treatment induces MAPK signaling in human monocytes

et al. 2014

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Abstract:The application of non-thermal atmospheric pressure plasma raises a hope for the new wound healing strategies. Next to its antibacterial effect it is known to stimulate skin cells. However, monocytes are also needed for the complex process of a wound healing. This study investigates the impact of plasma on the intracellular signaling events in the primary human monocytes. The proliferative MEK-ERK (MAPK/ERK kinase-extracellular signal-regulated kinase) pathway was activated by short plasma treatment times. In contrast, an induction of the apoptotic JNK (c-Jun N-terminal kinase) cascade as well as activation of caspase 3 were observed after long plasma exposure. These findings indicate that monocytes can be differentially stimulated by plasma treatment and may contribute to the proper wound recovery.

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Section: Apoptosis Induction In Response To Plasma Treatmentsupporting

confidence: 89%

Non-thermal plasma treatment induces MAPK signaling in human monocytes

et al. 2014

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“…This can be an indication that other ROS may be present after plasma treatment. 46 However, the 100% rescue observed by the presence of catalase seems to indicate that H 2 O 2 is the sole ROS active under these treatment conditions [Figs. 4 and 8(a)].…”

Section: -mentioning

confidence: 99%

Identification of the biologically active liquid chemistry induced by a nonthermal atmospheric pressure plasma jet

et al. 2015

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“…23 Due to the short half-life of the radicals, a chemical agent is necessary for detection. This so called spin trap was used to stabilize the radicals for sufficient time.…”

Section: F Electron Paramagnetic Resonance Spectroscopymentioning

confidence: 99%

“…More information about the detailed measurement procedure and the evaluation process can be found in a previous publication. 23 …”

Section: F Electron Paramagnetic Resonance Spectroscopymentioning

confidence: 99%

Impact of plasma jet vacuum ultraviolet radiation on reactive oxygen species generation in bio-relevant liquids

et al. 2015

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Plasma medicine utilizes the combined interaction of plasma produced reactive components. These are reactive atoms, molecules, ions, metastable species, and radiation. Here, ultraviolet (UV, 100–400 nm) and, in particular, vacuum ultraviolet (VUV, 10–200 nm) radiation generated by an atmospheric pressure argon plasma jet were investigated regarding plasma emission, absorption in a humidified atmosphere and in solutions relevant for plasma medicine. The energy absorption was obtained for simple solutions like distilled water (dH2O) or ultrapure water and sodium chloride (NaCl) solution as well as for more complex ones, for example, Rosewell Park Memorial Institute (RPMI 1640) cell culture media. As moderate stable reactive oxygen species, hydrogen peroxide (H2O2) was studied. Highly reactive oxygen radicals, namely, superoxide anion (O2•−) and hydroxyl radicals (•OH), were investigated by the use of electron paramagnetic resonance spectroscopy. All species amounts were detected for three different treatment cases: Plasma jet generated VUV and UV radiation, plasma jet generated UV radiation without VUV part, and complete plasma jet including all reactive components additionally to VUV and UV radiation. It was found that a considerable amount of radicals are generated by the plasma generated photoemission. From the experiments, estimation on the low hazard potential of plasma generated VUV radiation is discussed.

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Quantitative detection of plasma-generated radicals in liquids by electron paramagnetic resonance spectroscopy

Cited by 187 publications

References 48 publications

Non-thermal plasma treatment induces MAPK signaling in human monocytes

Non-thermal plasma treatment induces MAPK signaling in human monocytes

Identification of the biologically active liquid chemistry induced by a nonthermal atmospheric pressure plasma jet

Impact of plasma jet vacuum ultraviolet radiation on reactive oxygen species generation in bio-relevant liquids

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