Impact of plasma jet vacuum ultraviolet radiation on reactive oxygen species generation in bio-relevant liquids

Jablonowski, Helena; Bussiahn, R.; Hammer, Malte U.; Weltmann, K.‐D.; Woedtke, Thomas von; Reuter, Stephan

doi:10.1063/1.4934989

Cited by 84 publications

(80 citation statements)

References 36 publications

(43 reference statements)

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“…Findings show that an argon plasma emits very little in the ultraviolet range since spikes appear from 650 nm which is consistent with studies conducted on an argon plasma in 2003 by Guchardi R. and Hauser P.C. and in 2015 by Jablonowski H. et al [10,11]. On the other hand, in the presence of an Ar-O 2 plasmagene mixture (20%/80%) peaks appear in the ultraviolet spectrum.…”

Section: Characterization Of Plasma Radiationsupporting

confidence: 89%

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Thermo- and photo-oxidation reaction scheme in a treatment system using submerged plasma

Milelli

Lemont

Ruffel

et al. 2017

Chemical Engineering Journal

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Some of hazardous liquid organic wastes, radioactive or not, are waiting from outlet to be destroyed. The ELIPSE process is a new technology of organic liquid destruction, involving a thermal plasma working under a water column, which ensures the cooling, the filtration and the scrubbing of the gases coming from the degradation. This study deals with the ability of the ELIPSE process to destroy the pure organic liquids and then to reduce the amount of organic matter remaining in the aqueous solution by means of the thermal or radiative properties of plasma. Preliminary test have shown how efficient the process is for the destruction of the organic liquids when they are directly fed in the plasma hearth. Extensive researches have been performed to assess the ability of the submerged plasma to destroy the remaining organic matters either by reinjecting them with the aqueous solution into the plasma or by using the UV ray coming from the plasma itself. A comparison of the experimental results obtained with various mechanisms proposed by the work carried out highlighted that this UV radiation could, by excitation of water molecules, produce radicals OH° which may either dimerise to produce hydrogen peroxide H 2 O 2 , or react with organic substances present. The calculation of an activation energy of 8.5 ± 0.9kJ.mol-1 during the experiments shows that these radicals OH° act directly after having been formed which explains a low H 2 O 2 content stability when the solution contains organic compounds. Thus, this photooxidation taking place in the water column could be used to improve the destruction of residual organic matter in the solution by maintaining the plasma after processing a given amount of organic liquids.

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Section: Characterization Of Plasma Radiationsupporting

confidence: 89%

“…(H 2 O 2 ) c 3 . Thus K is the apparent kinetic constant of the reaction(11) which is order 1. The integration of this expression allows to link the change in ethanol concentration over time as per the equation(13):…”

mentioning

confidence: 99%

Thermo- and photo-oxidation reaction scheme in a treatment system using submerged plasma

Milelli

Lemont

Ruffel

et al. 2017

Chemical Engineering Journal

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“…For example, the DBD plasma may create nanopores [78] allowing the entry of species into cells by a process similar to aquaporins [79], a route potentially counteracted by excess liquid. Also, short wavelength UV radiation is efficiently scavenged by a few hundred nanometers of liquid layer [80]. A combination of different plasma properties is also possible as seen with bacteria [81][82][83].…”

Section: Discussionmentioning

confidence: 98%

A Comparison of Floating-Electrode DBD and kINPen Jet: Plasma Parameters to Achieve Similar Growth Reduction in Colon Cancer Cells Under Standardized Conditions

Bekeschus

Lin

Fridman

et al. 2017

Plasma Chem Plasma Process

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A comparative study of two plasma sources (floating-electrode dielectric barrier discharge, DBD, Drexel University; atmospheric pressure argon plasma jet, kINPen, INP Greifswald) on cancer cell toxicity was performed. Cell culture protocols, cytotoxicity assays, and procedures for assessment of hydrogen peroxide (H 2 O 2 ) were standardized between both labs. The inhibitory concentration 50 (IC50) and its corresponding H 2 O 2 deposition was determined for both devices. For the DBD, IC50 and H 2 O 2 generation were largely dependent on the total energy input but not pulsing frequency, treatment time, or total number of cells. DBD cytotoxicity could not be replicated by addition of H 2 O 2 alone and was inhibited by larger amounts of liquid present during the treatment. Jet plasma toxicity depended on peroxide generation as well as total cell number and amount of liquid. Thus, the amount of liquid present during plasma treatment in vitro is key in attenuating short-lived species or other physical effects from plasmas. These in vitro results suggest a role of liquids in or on tissues during plasma treatment in a clinical setting. Additionally, we provide a platform for correlation between different plasma sources for a predefined cellular response.

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“…Enzymatic activation can help verify the results [268]. As a remote technique, EPR can determine the effect of the plasma jet generated VUV radiation on radical generation in a small enclosed volume of liquid [269].…”

Section: Electron Paramagnetic Resonance Spectroscopymentioning

confidence: 98%

Reactive species in non-equilibrium atmospheric-pressure plasmas: Generation, transport, and biological effects

et al. 2016

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Non-equilibrium atmospheric-pressure plasmas have recently become a topical area of research owing to their diverse applications in health care and medicine, environmental remediation and pollution control, materials processing, electrochemistry, nanotechnology and other fields. This review focuses on the reactive electrons and ionic, atomic, molecular, and radical species that are produced in these plasmas and then transported from the point of generation to the point of interaction with the material, medium, living cells or tissues being processed. The most important mechanisms of generation and transport of the key species in the plasmas of atmospheric-pressure plasma jets and other non-equilibrium atmosphericpressure plasmas are introduced and examined from the viewpoint of their applications in plasma hygiene and medicine and other relevant fields. Sophisticated high-precision, timeresolved plasma diagnostics approaches and techniques are presented and their applications to monitor the reactive species and plasma dynamics in the plasma jets and other discharges, both in the gas phase and during the plasma interaction with liquid media, are critically reviewed. The large amount of experimental data is supported by the theoretical models of reactive species generation and transport in the plasmas, surrounding gaseous environments, and plasma interaction with liquid media. These models are presented and their limitations are discussed. Special attention is paid to biological effects of the plasma-generated reactive oxygen and nitrogen (and some other) species in basic biological processes such as cell metabolism, proliferation, survival, etc. as well as plasma applications in bacterial inactivation, wound healing, cancer treatment and some others. Challenges and opportunities for theoretical and experimental research are discussed and the authors' vision for the emerging convergence trends across several disciplines and application domains are presented to stimulate critical discussions and collaborations in the future. 4 3.5 Optical absorption spectroscopy 3.5.1 Ozone 3.5.2 UV broadband absorption of OH density 3.5.3 Cavity ring-down spectroscopy 3.5 Selected non-optical techniques 3.5.1 Mass spectrometry 3.5.2 Flow visualization 3.5.3 Electron paramagnetic resonance spectroscopy 4. Temporal and spatial behaviour of key reactive species 4.1 Electron density (n e) 4.2 O atoms 4.2.1 Effect of admixture of O 2 /air on O concentration 4.2.2 Diffusion effect of shielding gas on O production 4.3 OH radical 4.3.1 Effect of H 2 O admixture on OH concentration 4.3.2 Effect of gas flow on OH concentration 4.3.3 Effect of O 2 on OH production 4.3.4 Effect of the treated samples on OH concentration 4.3.4.1 Effect of humidity of treatment sample on OH distribution 4.3.4.2 Effect of sample conductivity on OH distribution 4.3.4.3. Effect of the amplitude of the applied voltage on OH distribution 4.3.4.4. The effect of gas flow on OH distribution 4.3.4.5. The effect of the surface characteristics on OH distribution 4.3.5 Effe...

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Impact of plasma jet vacuum ultraviolet radiation on reactive oxygen species generation in bio-relevant liquids

Cited by 84 publications

References 36 publications

Thermo- and photo-oxidation reaction scheme in a treatment system using submerged plasma

Thermo- and photo-oxidation reaction scheme in a treatment system using submerged plasma

A Comparison of Floating-Electrode DBD and kINPen Jet: Plasma Parameters to Achieve Similar Growth Reduction in Colon Cancer Cells Under Standardized Conditions

Reactive species in non-equilibrium atmospheric-pressure plasmas: Generation, transport, and biological effects

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