Quantitative data on the magnitude of the systemic inflammatory response and its effect on carotenoids status based on plasma measurements

Ghashut, Rawia A.; McMillan, Donald C.; Kinsella, John; Duncan, Andrew; Talwar, Dinesh

doi:10.1016/j.clnme.2013.07.006

Cited by 6 publications

(8 citation statements)

References 11 publications

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“…The results of the present study examining the effect of the systemic inflammatory response on plasma zinc and selenium concentrations may also have implications for other trace elements and vitamins in plasma that fall as part of the systemic inflammatory response [10,27]. Indeed, CRP is recognised to be the prototypical marker of the systemic inflammatory response [19].…”

Section: Tablementioning

confidence: 84%

The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin

et al. 2016

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Section: Tablementioning

confidence: 84%

The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin

et al. 2016

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“…In addition, local inflammation is thought to play a critical role in the progression of CLD and development of liver cancer ( Nikolaou et al , 2013 ). A growing literature has inversely linked systemic levels of inflammation with micronutrient status, possibly by effects on micronutrient metabolism in the liver ( Duncan et al , 2012 ; Gashut et al , 2013 ). Whether these data are relevant to our current findings is unclear, especially as the typically measured marker of systemic inflammation, C-reactive protein, is itself metabolised in the liver and may also be affected by underlying liver disease ( Pieri et al , 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Association of serum α-tocopherol, β-carotene, and retinol with liver cancer incidence and chronic liver disease mortality

et al. 2014

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Background:Micronutrients may influence the development or progression of liver cancer and liver disease. We evaluated the association of serum α-tocopherol, β-carotene, and retinol with incident liver cancer and chronic liver disease (CLD) mortality in a prospective cohort of middle-aged Finnish male smokers.Methods:Baseline and 3-year follow-up serum were available from 29 046 and 22 805 men, respectively. After 24 years of follow-up, 208 men were diagnosed with liver cancer and 237 died from CLD. Hazards ratios and 95% confidence intervals were calculated for highest vs lowest quartiles from multivariate proportional hazards models.Results:Higher β-carotene and retinol levels were associated with less liver cancer (β-carotene: 0.35, 0.22–0.55, P-trend <0.0001; retinol: 0.58, 0.39–0.85, P-trend=0.0009) and CLD mortality (β-carotene: 0.47, 0.30–0.75, P-trend=0.001; retinol: 0.55, 0.38–0.78, P-trend=0.0007). α-Tocopherol was associated with CLD mortality (0.63, 0.40–0.99, P-trend=0.06), but not with liver cancer (1.06, 0.64–1.74, P-trend=0.77). Participants with higher levels of β-carotene and retinol, but not α-tocopherol, at both baseline and year 3 had lower risk of each outcome than those with lower levels.Conclusions:Our findings suggest that higher concentrations of β-carotene and retinol are associated with incident liver cancer and CLD. However, such data do not indicate that supplementation should be considered for these diseases.

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“…Major inflammation was associated with median plasma vitamin C concentrations below the reference range in two of the three studies. There were four studies that examined plasma lutein concentrations in chronic diseases (18,(37)(38)(39) . Lutein concentrations were significantly lower with increasing CRP concentrations from minor to moderate to major inflammation by approximately 40 %.…”

Section: Systematic Reviewmentioning

confidence: 99%

“…There were five studies that examined plasma lycopene concentrations in chronic diseases (18,37,(39)(40)(41) . Lycopene concentrations were significantly lower with increasing CRP concentrations from minor to moderate to major inflammation by approximately 95 % in one study with no significant change in another study.…”

Section: Systematic Reviewmentioning

confidence: 99%

Relationship between nutritional status and the systemic inflammatory response: micronutrients

2018

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Micronutrients such as trace elements and vitamins are important as enzyme cofactors in the metabolism of all cells in the body and therefore key to determining nutritional status. The present systematic review examined the evidence of the impact of the systemic inflammatory response on plasma micronutrient status in acute (surgical) and chronic tissue injury. A literature review using targeted subject headings was carried out. Plasma C-reactive protein was used to classify minor (80 mg/l) inflammation. The literature search produced 2344 publications and plasma vitamin D, zinc and carotenoids were most commonly studied and plasma vitamins K, B2 and B6 were least studied. In acute injury thirteen studies (all prospective) and in chronic injury twenty-four studies (largely retrospective) were included in the review. There was consistent evidence that most common measured micronutrients in the plasma (zinc, selenium, vitamins A, D, E, K, B2, B6, B12, C, lutein, lycopene, α- and β-carotene) were significantly lowered from minor to moderate to major inflammation. The results of the present systematic review indicate that most plasma micronutrients fall as part of the systemic inflammatory response irrespective of acute or chronic injury. Therefore, in the presence of a systemic inflammation, plasma micronutrient concentrations should be interpreted with caution. There are a number of methods applied to adjust plasma micronutrient concentrations to avoid misdiagnosis of deficiency. Alternatively, intracellular measurements appear to obviate the need for such plasma adjustment to assess micronutrient status.

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Quantitative data on the magnitude of the systemic inflammatory response and its effect on carotenoids status based on plasma measurements

Cited by 6 publications

References 11 publications

The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin

The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin

Association of serum α-tocopherol, β-carotene, and retinol with liver cancer incidence and chronic liver disease mortality

Relationship between nutritional status and the systemic inflammatory response: micronutrients

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