The effect of the systemic inflammatory response on plasma zinc and selenium adjusted for albumin

Quantitative data on the magnitude of the systemic inflammatory response and its relationship with serum measures of iron status

“…The cohorts were divided into groups according to CRP (<10, 10-80, >80mg/L) and albumin concentrations (<25, 25-35, >35 g/L) as previously described. 8,[14][15] Furthermore, from these initial groupings, 3 groups with minimal (group 1, CRP <10mg/L and albumin >35g/L), moderate (group 2, CRP 10-80mg/L and albumin 25-35g/L) and maximal (group 3 CRP >80mg/L and albumin <25g/L) systemic inflammation were identified. The distribution of each 8 parameter of iron status were compared across strata of CRP and albumin using the Kruskal-Wallis test.…”

“…6 Indeed, recent studies have quantified the impact of the systemic inflammatory response, as evidenced by both serum C-reactive protein (CRP) and albumin, on serum vitamins and micronutrients. [7][8] With reference to iron status, hepcidin is a key regulator of iron homeostasis, acting to reduce iron export and cause sequestration of iron through the inhibition of ferroportin. 9 It is thought that hepcidin synthesis is influenced by cytokines such as interleukin 6 (IL 6), which promotes iron uptake by cells of the innate immune system.…”

Effect of Selenium on Ischemia-Reperfusion Injury in the Coronary Artery Bypass Graft Surgery: A Clinical Trial Study

“…By the way, correction of suboptimal Se statue after the onset of inflammation reaction does not prevent the worsening of tissue damage. Hence, a preemptive strategy is logical (16)(17)(18)(19)(20). A few related experimental and animal studies with meaningful results are available (21)(22)(23)(24).…”

Synaptic Zn2+ and febrile seizure susceptibility

“…However, in countries where Zn 2 + intake is adequate, patients with FS still have 15–20% lower serum Zn 2 + levels when compared with those with afebrile seizures (Lee and Kim, ). Although it is still an open question as to why Zn 2 + levels are lower in FS patients with normal diet intake, there is an emerging and strengthening relationship between elevated serum markers of inflammation and Zn 2 + deficiency (Murr et al, ; Jung et al, ; Ghashut et al, ). Furthermore, in a pig model of peritonitis, serum Zn 2 + levels drop by half 2 h post‐infection and over 75% by 6 h, with free Zn 2 + also falling (Hoeger et al, ).…”