Quantitative culture of Helicobacter pylori from gastric juice: the potential for transmission

Young, Kung Chia; Akyön, Yakut; Rampton, David; Barton, Sgrg; Allaker, R.P.; Hardie, J. M.; Feldman, Roger A.

doi:10.1099/0022-1317-49-4-343

Cited by 32 publications

(30 citation statements)

References 16 publications

(20 reference statements)

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“…Assuming that H. pylori colonizes only the human gastric mucosa, it has been postulated that gastro-oral transmission may occur, and this may be a possible route of spread during epidemic vomiting or regurgitation in children (22,23). This hypothesis has been supported by experimental (24)(25)(26) and clinical data (27)(28)(29). Poor personal hygiene may account for an increased risk of H. pylori infection in mentally disabled children, possibly following chronic gastric regurgitation or frequent vomiting by infected cohabiting children, either within or outside the family (e.g., at day care centers or kindergarten).…”

supporting

confidence: 52%

<i>Helicobacter pylori</i> Infection among Children with Phenylketonuria

2013

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SUMMARY: This study aimed to determine the frequency of Helicobacter pylori infections in children with phenylketonuria (PKU). Sixty-six children with PKU (35 boys, 31 girls; mean age, 8.2 ± 6.7 years) and 32 outpatient controls (15 boys, 17 girls; mean age, 9.6 ± 4.7 years) were studied. Socioeconomic factors did not differ between the two groups. The frequency of H. pylori infections was higher in patients with PKU (28.1z) than in healthy controls (9.4z). In particular, a higher frequency of infection was detected in patients with PKU with poor metabolic control (51.8z). The frequency of H. pylori infection in patients with PKU with good metabolic control was only 10.2z. There was no difference in the mean total WISC-R score between the poor and good metabolic control groups. A high frequency of H. pylori infection in children with PKU with poor metabolic control could be related to many factors. Advanced and standardized clinical studies on H. pylori infections in children with PKU are required.

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supporting

confidence: 52%

<i>Helicobacter pylori</i> Infection among Children with Phenylketonuria

2013

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“…Gastric juice is well adapted for performance of quantitative culture and estimation of the potential for transmission of this organism (153,593). In the study of induced vomitus from infected subjects, H. pylori grew in high quantities (Ͼ10 3 CFU/ ml), while low quantities (50 to 500 CFU/ml) were found in postemesis saliva and cathartic stools (2,000 to 5,000 CFU/ml) in most of the subjects (434).…”

Section: Vol 20 2007mentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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“…Only 5 of the samples collected from the 22 gastric biopsy-positive children were true gastric juice samples and contained no bile. However, the quantity of H. pylori cultured from the gastric juice of children (mean 6533 cfu=ml) was almost 10 3 -fold higher than in adults (median 18 cfu=ml) [16]. This may indicate that when H. pylori is present, children have a greater load of viable organisms in their stomach available for transmission via the mouth than adults.…”

Section: Overall Analysismentioning

confidence: 72%

“…H. pylori DNA can be detected in the gastric juice of gastric biopsy-positive individuals by PCR [11][12][13] but the reported detection of viable organisms in this fluid varies greatly [14][15][16]. As most H. pylori infection is acquired in childhood, gastro-oral spread may be more significant in children, in whom exposure to gastric contents through vomit is more common, but information on this age group is lacking.…”

Section: Introductionmentioning

confidence: 99%