Quantitative CT of the knee in the IMI-APPROACH osteoarthritis cohort: Association of bone mineral density with radiographic disease severity, meniscal coverage and meniscal extrusion

Heiß, Rafael; Laredo, Jean‐Denis; Wirth, W.; Jansen, M.; Marijnissen, A.C.; Lafeber, Floris P. J. G.; Lalande, Alain; Weinans, Harrie; Blanco, Francisco J.; Bérenbaum, Francis; Kloppenburg, Margreet; Haugen, I.K.; Engelke, Klaus; Roemer, Frank W.

doi:10.1016/j.bone.2023.116673

Cited by 2 publications

(1 citation statement)

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“…The association between OP, low BMD, and OA has increasingly been reported [19,74,111]. Heiss et al used quantitative CT to assess BMD at the femur and tibia, cortical bone plate, and epiphysis in three locations (subchondral, mid-epiphyseal, and juxtaphyseal) in 275 patients with KOA [112]. Patients with Kellgren-Lawrence grade 2-4 KOA had low BMD in the medial femoral condyle at all epiphyseal locations, and BMD decreased with increasing distance from the joint.…”

Section: Low Bone Mineral Density and Osteoarthritismentioning

confidence: 99%

Osteoporosis, Osteoarthritis, and Subchondral Insufficiency Fracture: Recent Insights

Yokota,

Ishizu,

Miyazaki

et al. 2024

Biomedicines

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The increased incidence of osteoarthritis (OA), particularly knee and hip OA, and osteoporosis (OP), owing to population aging, have escalated the medical expense burden. Osteoarthritis is more prevalent in older women, and the involvement of subchondral bone fragility spotlights its association with OP. Notably, subchondral insufficiency fracture (SIF) may represent a more pronounced condition of OA pathophysiology. This review summarizes the relationship between OA and OP, incorporating recent insights into SIF. Progressive SIF leads to joint collapse and secondary OA and is associated with OP. Furthermore, the thinning and fragility of subchondral bone in early-stage OA suggest that SIF may be a subtype of OA (osteoporosis-related OA, OPOA) characterized by significant subchondral bone damage. The high bone mineral density observed in OA may be overestimated due to osteophytes and sclerosis and can potentially contribute to OPOA. The incidence of OPOA is expected to increase along with population aging. Therefore, prioritizing OP screening, early interventions for patients with early-stage OA, and fracture prevention measures such as rehabilitation, fracture liaison services, nutritional management, and medication guidance are essential.

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