Quantitative correlations between collision induced dissociation mass spectrometry coupled with electrospray ionization or atmospheric pressure chemical ionization mass spectrometry – Experiment and theory

Solvent composition dependent signal reduction of molecular ions generated from aromatic compounds in (+) atmospheric pressure photoionization mass spectrometry

“…For this reason, a considerable amount of effort has been devoted to improving the analytical sensitivity of LC/MS, and it is well known that ionization is a critical step that can greatly influence the analytical sensitivity of LC/MS . In addition, theoretical study combined with experimental MS data has been shown to be effective in studying the ionization behavior of aromatic compounds at atmospheric pressure …”

“…21 In addition, theoretical study combined with experimental MS data has been shown to be effective in studying the ionization behavior of aromatic compounds at atmospheric pressure. [27][28][29][30] Atmospheric pressure photoionization (APPI) is one of the ionization techniques used in LC/MS to measure low-or non-polar aromatic compounds. 5,22,31,32 In LC/APPI-MS, toluene is typically used as a dopant to improve ionization efficiency.…”