Quantitative Computed Tomographic Indexes in Diffuse Interstitial Lung Disease

Abstract

Quantitative indexes measured by a commercial workstation showed good correlation not only with the extent of DILD estimated by visual inspection but also with PFT results. Quantitative indexes can be used as an objective tool for quantitative evaluation of disease extent and for follow-up of the progression or improvement of a DILD.

High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study

“…Others have used alternative definitions of HAA (-700 to 0 HU, -700 to -500 HU) [45-47], histogram characteristics, and other automated methods [48-51], including texture-based methods [52], to identify and characterize clinically evident ILD, but not subclinical changes. Recent studies have examined the associations between visually-identified ILA and mortality [9], but ours is the first study of HAA as a quantitative measure of lung injury and inflammation that is associated with a higher rate of death in community dwelling adults sampled without regard to lung disease, symptoms, or smoking status.…”

Quantitative CT indexes are significantly associated with exercise oxygen desaturation in interstitial lung disease related to systemic sclerosis

“…age, gender) . The correlations between functional and radiological outcomes are so weak that many Authors suggested they should be considered together in SSc‐ILD assessment .…”

Computer-Aided Quantification of Interstitial Lung Disease from High Resolution Computed Tomography Images in Systemic Sclerosis: Correlation with Visual Reader-Based Score and Physiologic Tests

“…CT attenuation of normal lung parenchyma is reported to range from −800 to −900 HU, depending on inspiration or expiration, on the level of inspiration achieved for the scan, and on anatomical location that is ventral or dorsal portion [ 25 ]. Shin et al [ 20 ] defined the area with attenuation between −500 and −700 as the value of radiodensity for ILD. The author included both ground-glass opacity and reticular opacity.…”

“…The radiodensity of the lung parenchyma isolated from the mediastinum and the thoracic wall ranges between −200 and −1024. According to Shin et al [ 20 ], the value of radiodensity for ILD was considered from −700 to −500. So, in the present study, the thresholds of −1024 and −700 were used for the evaluation of the nonfibrotic HRCT lung volume.…”