Quantitative, clinically relevant acoustic measurements of focal embouchure dystonia

Morris, Aimee; Norris, Scott A.; Perlmutter, Joel S.; Mink, Jonathan W.

doi:10.1002/mds.27298

Cited by 12 publications

(9 citation statements)

References 25 publications

(41 reference statements)

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Section: Discussionsupporting

confidence: 90%

“…We replicated the previous finding that patients with ED exhibited greater variability of F0 signals than HCs during tone production (Lee et al, ; Morris et al, ). Those pioneering studies demonstrated that variability of F0 signals during tone production serves as a hallmark of ED (Lee et al, ; Morris et al, ), supporting the notion that quantification of F0 variability reflects dystonic symptoms of ED. Although the neural correlates of this symptom had not previously been identified, we found a correlation between F0 variability and brain activity, lending further support to the notion that F0 variability is a reliable behavioral measure for assessing individual differences in ED severity.…”

Section: Discussionmentioning

confidence: 99%

“…The motivation for assessing the hand motor representation with the localizer fMRI was to define a reference location for Euclidean distances between the mouth and hand representations (Hirata et al, ; Morris et al, ) (see Section 2.8 for details).…”

Section: Methodsmentioning

confidence: 99%

“…Here, we investigated brain activity during an embouchure task and somatotopic representations during motor localizer tasks, and tested which better explained a behavioral marker representing dystonic symptoms in ED. For a reliable behavioral biomarker reflecting the severity of ED, we utilized a previous finding that patients with ED have greater fundamental frequency (F0) variability than healthy players (Lee, Furuya, Morise, Iltis, & Altenmüller, ; Morris, Norris, Perlmutter, & Mink, ). We used variability of F0 signals as an objective and quantitative marker representing symptoms in ED.…”

Section: Introductionmentioning

confidence: 99%

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Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia

Uehara

Furuya

Numazawa

et al. 2018

Human Brain Mapping

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Two main neural mechanisms including loss of cortical inhibition and maladaptive plasticity have been thought to be involved in the pathophysiology of focal task‐specific dystonia. Such loss of inhibition and maladaptive plasticity likely correspond to cortical overactivity and disorganized somatotopy, respectively. However, the most plausible mechanism of focal task‐specific dystonia remains unclear. To address this question, we assessed brain activity and somatotopic representations of motor‐related brain areas using functional MRI and behavioral measurement in healthy instrumentalists and patients with embouchure dystonia as an example of focal task‐specific dystonia. Dystonic symptoms were measured as variability of fundamental frequency during long tone playing. We found no significant differences in brain activity between the embouchure dystonia and healthy wind instrumentalists in the motor‐related areas. Assessment of somatotopy, however, revealed significant differences in the somatotopic representations of the mouth area for the right somatosensory cortex between the two groups. Multiple‐regression analysis revealed brain activity in the primary motor and somatosensory cortices, cerebellum, and putamen was significantly associated with variability of fundamental frequency signals representing dystonic symptoms. Conversely, somatotopic representations in motor‐related brain areas were not associated with variability of fundamental frequency signals in embouchure dystonia. The present findings suggest that abnormal motor‐related network activity and aberrant somatotopy correlate with different aspects of mechanisms underlying focal task‐specific dystonia.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia

Uehara

Furuya

Numazawa

et al. 2018

Human Brain Mapping

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“…20 Palpation of the embouchure is essential to look for tenderness or nodules in order to rule out other causes of embouchure discomfort. 7 Quantification of severity of ED can also be attempted based on acoustic measures 30,31 (Table 1). On studying the acoustic analysis, high registers are most severely affected.…”

Section: Diagnosismentioning

confidence: 99%

Dystonia in Performing Artists: Beyond Focal Hand Dystonia

Ray

Pal

2021

Can. J. Neurol. Sci.

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Overuse of specific muscles in perfecting movements in performing arts makes an artist prone to many medical conditions. Musicians’ hand dystonia is focal task-specific dystonia (FTSD) of hand among musicians that has been extensively studied. However, embouchure, lower limbs, and laryngeal muscles can also be affected among musicians. Embouchure dystonia (ED) refers to dystonia of the perioral and facial muscles that occurs in musicians while playing embouchure instruments. It is essential to identify ED since the dystonia might become persistent and non-task-specific if the musician continues to play the instrument. Task-specific dystonia of lower limbs among musicians has been exclusively reported among drummers. The diagnosis rests on electromyogram (EMG) of the involved muscles during the task. Singer’s dystonia (SD) refers to task-specific laryngeal dystonia that occurs only while singing. The diagnosis of SD is based on laryngeal EMG and spectrographic analysis. Cortical hyperexcitability, loss of inhibition, and aberrant plasticity are central to the pathogenesis in both ED and musicians’ hand dystonia. The pathophysiological studies in SD are limited. This review aims to discuss the lesser known dystonias among performing artists – ED, FTSD of lower limb, and SD.

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Sensorimotor Incoordination in Musicians’ Dystonia

Furuya

Oku

2023

Advances in Neurobiology

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Quantitative, clinically relevant acoustic measurements of focal embouchure dystonia

Cited by 12 publications

References 25 publications

Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia

Distinct roles of brain activity and somatotopic representation in pathophysiology of focal dystonia

Dystonia in Performing Artists: Beyond Focal Hand Dystonia

Sensorimotor Incoordination in Musicians’ Dystonia

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