Sensorimotor Incoordination in Musicians’ Dystonia

Furuya, Shinichi; Oku, Tatsuo

doi:10.1007/978-3-031-26220-3_4

Cited by 2 publications

(1 citation statement)

References 59 publications

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“…Historically, the impairment of motor control in MD parallels the alteration of the somatosensory representation of the dystonic body region observed in task-specific dystonia in animal models and in musicians (Candia et al, 2003). Recent data lend weight to an alternative hypothesis that task-specific dystonia is due to a higherorder disruption of skill encoding (Doll-Lee et al, 2023;Furuya and Oku, 2023;Sadnicka et al, 2023). This evidence supports therapeutic interventions aimed at the specific skill involved and its control network, supporting the interruption of ingrained motor behaviors by injecting variability into movement repetitions (Sadnicka and Rosset-Llobet, 2019).…”

Section: Introductionmentioning

confidence: 99%

Musician's dystonia: an opinion on novel treatment strategies

Grifoni,

Crispiatico,

Castagna

et al. 2024

Front. Neurosci.

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Section: Introductionmentioning

confidence: 99%

Musician's dystonia: an opinion on novel treatment strategies

Grifoni,

Crispiatico,

Castagna

et al. 2024

Front. Neurosci.

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Boundaries of task-specificity: bimanual finger dexterity is reduced in musician’s dystonia

Sadnicka,

Wiestler,

Butler

et al. 2024

Sci Rep

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Task-specific dystonia leads to loss of sensorimotor control for a particular motor skill. Although focal in nature, it is hugely disabling and can terminate professional careers in musicians. Biomarkers for underlying mechanism and severity are much needed. In this study, we designed a keyboard device that measured the forces generated at all fingertips during individual finger presses. By reliably quantifying overflow to other fingers in the instructed (enslaving) and contralateral hand (mirroring) we explored whether this task could differentiate between musicians with and without dystonia. 20 right-handed professional musicians (11 with dystonia) generated isometric flexion forces with the instructed finger to match 25%, 50% or 75% of maximal voluntary contraction for that finger. Enslaving was estimated as a linear slope of the forces applied across all instructed/uninstructed finger combinations. Musicians with dystonia had a small but robust loss of finger dexterity. There was increased enslaving and mirroring, primarily during use of the symptomatic hand (enslaving p = 0.003; mirroring p = 0.016), and to a lesser extent with the asymptomatic hand (enslaving p = 0.052; mirroring p = 0.062). Increased enslaving and mirroring were seen across all combinations of finger pairs. In addition, enslaving was exaggerated across symptomatic fingers when more than one finger was clinically affected. Task-specific dystonia therefore appears to express along a gradient, most severe in the affected skill with subtle and general motor control dysfunction in the background. Recognition of this provides a more nuanced understanding of the sensorimotor control deficits at play and can inform therapeutic options for this highly disabling disorder.

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Sensorimotor Incoordination in Musicians’ Dystonia

Cited by 2 publications

References 59 publications

Musician's dystonia: an opinion on novel treatment strategies

Musician's dystonia: an opinion on novel treatment strategies

Boundaries of task-specificity: bimanual finger dexterity is reduced in musician’s dystonia

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