Quantitative characterization of metastatic disease in the spine. Part I. Semiautomated segmentation using atlas‐based deformable registration and the level set method

Hardisty, Michael; Gordon, Lyle M.; Agarwal, Praveen; Skrinskas, T.; Whyne, Cari

doi:10.1118/1.2746498

Cited by 45 publications

(33 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Trabecular bone within the second lumbar vertebral body was segmented using a validated semi-automated thresholding technique (AmiraDev 5.2; TGS, Berlin, Germany) [13,14]. Stereological parameters of bone surface, bone volume (BV), and bone mineral density were measured to quantify the following trabecular bone parameters: trabecular bone volume fraction, trabecular bone surface to bone volume fraction, trabecular thickness, trabecular number, trabecular spacing, trabecular BMD, and trabecular volumetric BMD.…”

Section: Microcomputed Tomography (Lct) Analysismentioning

confidence: 99%

Local treatment of mixed osteolytic/osteoblastic spinal metastases: is photodynamic therapy effective?

Wise-Milestone

Akens

et al. 2011

Breast Cancer Res Treat

View full text Add to dashboard Cite

The widespread use of systemic and local therapies aimed at spinal metastatic lesions secondary to breast cancer has increased the incidence of mixed osteolytic/osteoblastic patterns of bony disease. The complex structure of these lesions requires novel therapeutic approaches to both reduce tumor burden and restore structural stability. In photodynamic therapy (PDT), a minimally invasive approach can be used to employ light to activate a photosensitizing agent that preferentially accumulates in tumor tissue, leading to cell toxicity and death. Previous work in an osteolytic rat model (MT-1) demonstrated that PDT effectively ablates tumor and improves vertebral structural properties. The aim of this study was to assess the efficacy of PDT in a rat model of mixed osteolytic/osteoblastic spinal metastases. Mixed spinal metastases were generated through intracardiac injection of Ace-1 canine prostate cancer cells into female athymic rats (day 0). A single PDT treatment was applied to lumbar vertebra L2 of tumor-bearing and healthy control rats (day 14). PDT-treated and untreated control rats were euthanized and excised spines imaged with μCT to assess bone quality (day 21). Spines were mechanically tested or histologically processed to assess mechanical integrity, tumor burden, and remodelling properties. Untreated tumor-bearing vertebrae showed large areas of osteolysis and areas of immature, new bone formation. The overall bone quality resulting from these lesions consisted of decreased structural properties but without a significant reduction in mechanical integrity. PDT was shown to significantly decrease tumor burden and osteoclastic activity, thereby improving vertebral bone structural properties. While non-tumor-bearing vertebrae exhibited significantly more new bone formation following PDT, the already heightened level of new bone formation in the mixed tumor-bearing vertebrae was not further increased. As such, the effect of PDT on mixed metastases may be more influenced by suppression of osteoclastic resorption as opposed to the triggering of new bone formation.

show abstract

Section: Microcomputed Tomography (Lct) Analysismentioning

confidence: 99%

Local treatment of mixed osteolytic/osteoblastic spinal metastases: is photodynamic therapy effective?

Wise-Milestone

Akens

et al. 2011

Breast Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…Trabecular bone within the L2 vertebral body was segmented using a validated semi-automated thresholding technique (AmiraDev 4.1.1; TGS, Berlin, Germany) [7]. From the vertebral segmentation, bone surface (BS), bone volume (BV), and bone mineral density (BMD) were determined and the following stereological parameters quantified: trabecular bone volume fraction (BV/TV), trabecular architecture (thickness, spacing, and number) [8], trabecular bone surface to bone volume fraction (BS/BV), trabecular BMD, trabecular volumetric BMD (vBMD), cortical BMD, and cortical shell mass fraction.…”

Section: Architectural Analysismentioning

confidence: 99%

Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue

Won

Wise-Milestone

Akens

et al. 2010

Breast Cancer Res Treat

View full text Add to dashboard Cite

Breast cancer patients commonly develop metastases in the spine, which compromises its mechanical stability and can lead to skeletal related events. The current clinical standard of treatment includes the administration of systemic bisphosphonates (BP) to reduce metastatically induced bone destruction. However, response to BPs can vary both within and between patients, which motivates the need for additional treatment options for spinal metastasis. Photodynamic therapy (PDT) has been shown to be effective at treating metastatic lesions secondary to breast cancer in an athymic rat model, and is proposed as a treatment for spinal metastasis. The objective of this study was to determine the effect of PDT, alone or in combination with previously administered systemic BPs, on the structural and mechanical integrity of both healthy and metastatically involved vertebrae. Human breast carcinoma cells (MT-1) were inoculated into athymic rats (day 0). At 14 days, a single PDT treatment was administered, with and without previous BP treatment at day 7. In addition to causing tumor necrosis in metastatically involved vertebrae, PDT significantly reduced bone loss, resulting in strengthening of the vertebrae compared to untreated controls. Combined treatment with BP + PDT further enhanced bone architecture and strength in both metastatically involved and healthy bone. Overall, the ability of PDT to both ablate malignant tissue and improve the structural integrity of vertebral bone motivates its consideration as a local minimally invasive treatment for spinal metastasis secondary to breast cancer.

show abstract

“…One of the major applications is the segmentation of 2D images by registration to a 3D atlas or the segmentation of data sets from individual subjects by using a 3D statistical model. 4,10,15 In this study, we compared the use of binary VOI masks with the use of segmented gray value VOIs as registration input. We were specifically interested in the organ bone; therefore, we restricted this study to rigid registration.…”

Section: Introductionmentioning

confidence: 99%

Binary Segmentation Masks Can Improve Intrasubject Registration Accuracy of Bone Structures in CT Images

et al. 2010

View full text Add to dashboard Cite

Registration of bone structures is a common problem in medical research as well as in clinical applications. Intrasubject rigid 3D monomodality registration of segmented bone structures of CT images and multimodality registration of muMR and segmented muCT bone images were performed with the multiresolution intensity-based technique implemented in ITK. The registration results for binary volumes of interest (VOI) masks and for segmented gray value VOIs were compared. To determine the registration quality, in the monomodality case the sum of squared difference, the sum of absolute differences, and the normalized symmetric difference of binary masks and in the multimodality case Mattes mutual information were applied. The use of binary VOI masks was significantly superior to the use of gray value VOIs.

show abstract

Quantitative characterization of metastatic disease in the spine. Part I. Semiautomated segmentation using atlas‐based deformable registration and the level set method

Cited by 45 publications

References 31 publications

Local treatment of mixed osteolytic/osteoblastic spinal metastases: is photodynamic therapy effective?

Local treatment of mixed osteolytic/osteoblastic spinal metastases: is photodynamic therapy effective?

Beyond bisphosphonates: photodynamic therapy structurally augments metastatically involved vertebrae and destroys tumor tissue

Binary Segmentation Masks Can Improve Intrasubject Registration Accuracy of Bone Structures in CT Images

Contact Info

Product

Resources

About