Quantitative biomolecular imaging by dynamic nanomechanical mapping

Zhang, Shuai; Aslan, Hüsnü; Besenbacher, Flemming; Dong, Mingdong

doi:10.1039/c4cs00176a

Cited by 70 publications

(70 citation statements)

References 198 publications

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“…[46][47][48] The maximum indentation force exerted by the tip on the sample during each tap is called 'peak force' and used as a feedback parameter to achieve a topographic image.…”

Section: Peakforce Quantitative Nanomechanical Property Mappingmentioning

confidence: 99%

Growth and Dissolution of Calcite in the Presence of Adsorbed Stearic Acid

Ricci¹,

Segura²,

Erickson³

et al. 2015

Langmuir

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The interaction of organic molecules with the surface of calcite plays a central role in many geochemical, petrochemical and industrial processes and in biomineralization. Adsorbed organics, typically fatty acids, can interfere with the evolution of calcite when immersed in aqueous solutions. Here we use atomic force microscopy in liquid to explore in real-time the evolution of the (101 ത 4) surface of calcite covered with various densities of stearic acid and exposed to different saline solutions. Our results show that the stearic acid molecules tend to act as 'pinning points' on the calcite's surface and slow down the crystal's restructuring kinetics. Depending on the amount of material adsorbed, the organic molecules can form monolayers or bilayer islands that become embedded into the growing crystal. The growth process can also displaces the organic molecules and actively concentrate them into stacked multilayers. Our results provide molecular-level insights into the interplay between the adsorbed fatty acid molecules and the evolving calcite crystal, highlighting mechanisms that could have important implications for several biochemical and geochemical processes and for the oil industry.

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“…[46][47][48] The maximum indentation force exerted by the tip on the sample during each tap is called 'peak force' and used as a feedback parameter to achieve a topographic image.…”

Section: Peakforce Quantitative Nanomechanical Property Mappingmentioning

confidence: 99%

Growth and Dissolution of Calcite in the Presence of Adsorbed Stearic Acid

Ricci¹,

Segura²,

Erickson³

et al. 2015

Langmuir

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show abstract

“…In some cases, the AFM data have revealed remarkable changes in the elastic response of cells under different physiological conditions. In particular, stiffness indicators are applied to track different physiological and pathological processes in cells [12][13][14][15][16][17][18][19][20][21][22] or the surrounding extra cellular matrix. 23,24 The cytoplasm consists of solid elements such as cytoskeleton, organelles and ribosomes in a liquid fluid (cytosol).…”

Section: Introductionmentioning

confidence: 99%

Time-resolved nanomechanics of a single cell under the depolymerization of the cytoskeleton

2017

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Single cell stiffness measurements consider cells as passive and elastic materials which react instantaneously to an external force. This approximation is at odds with the complex structure of the cell which includes solid and liquid components. Here we develop a force microscopy method to measure the time and frequency dependencies of the elastic modulus, the viscosity coefficient, the loss modulus and the relaxation time of a single live cell. These parameters have different time and frequency dependencies. At low modulation frequencies (0.2-4 Hz), the elastic modulus remains unchanged; the loss modulus increases while the viscosity and the relaxation time decrease. We have followed the evolution of a fibroblast cell subjected to the depolymerization of its F-actin cytoskeleton. The elastic modulus, the loss modulus and the viscous coefficient decrease with the exposure time to the depolymerization drug while the relaxation time increases. The latter effect reflects that the changes in the elastic response happen at a higher rate than those affecting the viscous flow. The observed behavior is compatible with a cell mechanical response described by the poroelastic model.

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“…During each resonance cycle, the tip engages the surface and then is retraced from it at a given amplitude; thereby, hundreds of FDCs can be produced in matter of milliseconds [155,156]. This AFM mode has gained increased popularity in the field of surface characterization of biological materials [157,158]. With the sinusoidal modulation of the z-piezoelement, small normal forces can be applied more precisely compared to conventional force volume mode.…”

Section: Nanoscale Adhesion On Viscoelastic Surfacesmentioning

confidence: 99%

Multiscale Frictional Properties of Cotton Fibers: A Review

Hosseinali

Thomasson

2018

Fibers

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This review discusses the important concept of cotton fiber friction at both the macro-and nanoscale. First, the technological importance of fiber friction and its role in fiber breakage during fiber processing is discussed. Next, previous studies on frictional properties of cotton fibers are reviewed and different experimental procedures to measure friction between fibers or against another surface are evaluated. Friction models developed to explain friction process during various experimental procedures are considered and their limitations are discussed. Since interpretation of friction processes at the macroscale can be challenging (mainly due to difficulties in analyzing the multiple asperities in contact), a separate section is devoted to surveying studies on the emerging field of single-asperity friction experiments with atomic force microscope (AFM). Special attention is given to studies on nanoscale frictional characteristics of rough viscoelastic surfaces (e.g., plant cuticular biopolymers and cotton fibers). Due to the close relationship between friction and adhesion hysteresis at the nanoscale, adhesion studies with AFM on viscoelastic surfaces are also reviewed. Lastly, recommendations are made for future research in the field of frictional properties of cotton fibers.

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Quantitative biomolecular imaging by dynamic nanomechanical mapping

Cited by 70 publications

References 198 publications

Growth and Dissolution of Calcite in the Presence of Adsorbed Stearic Acid

Growth and Dissolution of Calcite in the Presence of Adsorbed Stearic Acid

Time-resolved nanomechanics of a single cell under the depolymerization of the cytoskeleton

Multiscale Frictional Properties of Cotton Fibers: A Review

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