Quantitative assessment of the effect of acute anaerobic exercise on macular perfusion via swept-source optical coherence tomography angiography in young football players

Karaküçük, Yalçın; Okudan, Nilsel; Bozkurt, Banu; Belviranlı, Muaz; Sezer, Tuğba; Gorcuyeva, Sona

doi:10.1007/s10792-020-01303-w

Cited by 8 publications

(6 citation statements)

References 31 publications

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“…In line with our findings, one study in Germany showed protective effect of PA on fundus among healthy adults with the mean FAZ area in the deep retinal plexus decreased by 14.00 ± 13.02% after a 4-week high-intensity interval training [13]. Similarly, Yalçın et al found a reduction in FAZ area of the deep capillary plexus after acute anaerobic exercise [17] while Pressler et al [10] reported a significantly greater arteriolar-to-venular ratio (i.e., larger arterioles and smaller venules) in marathon runners compared with their age-matched sedentary controls. In contrast, a recent cross-sectional study comparing the neurovascular structures between 30 adult athletes and 30 nonathletes detected an increased FAZ perimeter in nonathletes [18].…”

Section: Discussionsupporting

confidence: 91%

Association of Physical Activity with Retinal Thickness and Vascular Structure in Elderly Chinese Population

et al. 2022

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Introduction: We aimed to assess the association of physical activity (PA) with retinal thickness and vascular structure in an elderly Chinese population. Methods: This study enrolled 220 retirees aged 50 years and above from Tianjin University of Sport, China. PA data gathered through the International Physical Activity Questionnaires were computed for metabolic equivalent of task-minutes per week. All participants underwent full ophthalmic examination including optical coherence tomography angiography (OCTA). Multiple linear regression analyses were used to evaluate the association of PA with retinal thickness and vascular structure. Results: A high amount of total PA was associated with smaller size of foveal avascular zone (FAZ) (high vs. low: area, β=-0.04; circumference β=-0.14) and greater central vessel (VD) (β=1.04) and perfusion densities (PD) (β=0.02). For domain-specific PA, participants with high and moderate recreational PA levels were found to have greater central VDs and PDs. Non-leisure activities demonstrated negative relationship with FAZ perimeter ratio (moderate vs. low: β=-0.08; high vs. low: β=-0.13) and, counter-intuitively, negative relation with VDs measured at the inner (high vs. low: β=-0.98) and outer retinal layers (high vs. low: β=-0.38). Additionally, higher levels of total PA were related to increased macular fovea thickness and average thickness of retinal nerve fiber layer. Conclusions: High PA level, particularly recreational PA, was associated with smaller FAZ and greater VD and PD in senior adults. Non-leisure time PA might not confer the same health benefits as leisure time PA. Our data supports a possible protective role of recreational PA in the retina against microvascular changes.

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Section: Discussionsupporting

confidence: 91%

Association of Physical Activity with Retinal Thickness and Vascular Structure in Elderly Chinese Population

et al. 2022

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“…Given that physical activity is known to alter blood flow in a variety of organs and tissues, choroidal effects would seem plausible. However, while early studies showed changes in choroidal blood flow with exercise as measured with laser Doppler flowmetry, 160 most studies examining ocular parameters shortly after physical exercise did not detect significant changes in choroidal thickness, 151 , 161 – 164 with the exception in some studies of a temporary choroidal thickening a few minutes after exercise, followed by a reduction in thickness. 4 , 150 On the other hand, thinning of the choroid was observed after endurance exercise (marathon running).…”

Section: Short-term Influences On Choroidal Thicknessmentioning

confidence: 99%

IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

Ostrin

Harb

Nickla

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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The choroid is the richly vascular layer of the eye located between the sclera and Bruch's membrane. Early studies in animals, as well as more recent studies in humans, have demonstrated that the choroid is a dynamic, multifunctional structure, with its thickness directly and indirectly subject to modulation by a variety of physiologic and visual stimuli. In this review, the anatomy and function of the choroid are summarized and links between the choroid, eye growth regulation, and myopia, as demonstrated in animal models, discussed. Methods for quantifying choroidal thickness in the human eye and associated challenges are described, the literature examining choroidal changes in response to various visual stimuli and refractive error-related differences are summarized, and the potential implications of the latter for myopia are considered. This review also allowed for the reexamination of the hypothesis that short-term changes in choroidal thickness induced by pharmacologic, optical, or environmental stimuli are predictive of future long-term changes in axial elongation, and the speculation that short-term choroidal thickening can be used as a biomarker of treatment efficacy for myopia control therapies, with the general conclusion that current evidence is not sufficient.

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“…The blood flow in the retina maintains a constant perfusion level through the intricate interplay between neurovascular coupling, myogenic responses, flow-mediated mechanisms, and metabolic processes, facilitated by the release of vasoactive substances from the endothelium and retinal tissue (Koller and Toth, 2012). The capillary endothelial cells and the vascular smooth muscle cells are responsible for the pressuredependent myogenic constriction (Bayliss-effect) and flowdependent nitric oxide (NO)-induced dilation by means of shear stress (Hanssen et al, 2022).…”

Section: Glaucoma and The Retinal Microcirculationmentioning

confidence: 99%

“…A similar retinal vessel diameter constellation was found in POAG patients when compared to healthy subjects ( Chiquet et al, 2020 ). Moreover, impaired retinal flicker-induced dilation (FID) correlates with increased CV risk in diabetes ( Valenzuela et al, 2023 ), hyperglycemia ( Green and Smith, 2018 ), hypertension ( Vera et al, 2019 ), dyslipidemia ( Karakucuk et al, 2020 ), obesity ( Kaminsky et al, 2013 ), coronary artery disease ( Ramos et al, 2015 ), and chronic kidney disease ( Whyte et al, 2013 ). Blood flow alterations in the optic nerve head (ONH) have been identified as a significant risk for development and progression of glaucoma, highlighting the importance of the vascular system’s responsiveness to metabolic changes for disease progression ( Flammer et al, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

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High-intensity interval training in patients with glaucoma (HIT-GLAUCOMA): protocol for a multicenter randomized controlled exercise trial

Van Eijgen,

Schuhmann,

Fingerroos

et al. 2024

Front. Physiol.

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BackgroundGlaucoma stands as a prominent global cause of irreversible blindness and the primary treatment approach involves reducing intraocular pressure (IOP). However, around one-third of patients exhibit disease progression despite effective IOP reduction. Microvascular endothelial function, chronic inflammation, and oxidative stress are known to affect retinal neuronal networks and have been associated with disease severity and progression. Exercise training has the potential to counteract these mechanisms as add-on treatment to usual care.AimsThe HIT-GLAUCOMA study will investigate the effects of a 6-month high-intensity interval training (HIIT) on intermediate endpoints such as local retinal microvascular and systemic large artery function, inflammation, and oxidative stress as well as clinical endpoints such as visual field indices, optic nerve rim assessment, retinal nerve fiber layer thickness, IOP, number of eye drops, vision-related quality of life and ocular surface disease symptomatology.MethodsThe study is a multi-center randomized controlled clinical trial in patients with both normal tension and high-tension primary open angle glaucoma. Across two study centers, 128 patients will be enrolled and randomized on a 1:1 basis into an exercise intervention group and a usual care control group. The primary microvascular endpoints are retinal arteriolar and venular flicker light-induced dilation at 6 months. The primary endpoint in the systemic circulation is brachial artery flow-mediated dilation at 6 months.Anticipated resultsWe hypothesize that exercise therapy will improve retinal microvascular function and thus ocular blood flow in patients with glaucoma. As clinical outcomes, we will investigate the effect of exercise on visual field indices, optic nerve rim assessment, retinal nerve fiber layer thickness, IOP, number of eye drops, vision-related quality of life and ocular surface disease symptomatology.DiscussionHIT-GLAUCOMA is a blueprint trial design to study the effect of exercise training on neurodegenerative and cardiovascular diseases. Importantly, patients are also expected to benefit from improvements in general health and cardiovascular co-morbidities. If proven effective, exercise may offer a new add-on treatment strategy to slow glaucoma progression.Clinical Trial Registration NumberThe trial is registered at Clinicaltrials.gov under the identifier NCT06058598 and is currently in the recruitment stage.

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Quantitative assessment of the effect of acute anaerobic exercise on macular perfusion via swept-source optical coherence tomography angiography in young football players

Cited by 8 publications

References 31 publications

Association of Physical Activity with Retinal Thickness and Vascular Structure in Elderly Chinese Population

Association of Physical Activity with Retinal Thickness and Vascular Structure in Elderly Chinese Population

IMI—The Dynamic Choroid: New Insights, Challenges, and Potential Significance for Human Myopia

High-intensity interval training in patients with glaucoma (HIT-GLAUCOMA): protocol for a multicenter randomized controlled exercise trial

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