Quantitative assessment of regional left ventricular function with cardiac MRI: Three‐dimensional centersurface method

Beohar, Nirat; Flaherty, James; Davidson, Charles J.; Vidovich, Mladen I.; Brodsky, Adam; Lee, Daniel; Wu, Edwin; Bolson, Edward L.; Bonow, Robert O.; Sheehan, Florence H.

doi:10.1002/ccd.21048

Cited by 19 publications

(9 citation statements)

References 24 publications

(37 reference statements)

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“…Van der Geest et al (10) and Holman et al (11) have proposed a 3D technique based on a straightforward extension of the 2D centerline method. More recently, Beohar et al analyzed regional LV function with cardiac MRI after myocardial infarction using a very similar approach (13). However, these techniques are inherently straight-line based, and thus can be sensitive to imperfect contours.…”

Section: Discussionmentioning

confidence: 99%

“…Several authors have constructed phantoms with a known wall thickness for evaluation purposes (10, 12). In in-vivo studies, many authors have presented wall motion results in the context of theoretical and clinical considerations (10, 12, 13). However, for the quantitative wall motion algorithm to be used clinically, a thorough validation using the standard visual assessment is necessary.…”

Section: Introductionmentioning

confidence: 99%

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Quantification of 3D regional myocardial wall thickening from gated magnetic resonance images

Prasad

Rauthan

Kavanagh

et al. 2010

Magnetic Resonance Imaging

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Purpose: To develop 3D quantitative measures of regional myocardial wall motion and thickening using cardiac magnetic resonance imaging (MRI) and to validate them by comparison to standard visual scoring assessment. Materials and Methods:In all, 53 consecutive subjects with short-axis slices and mid-ventricular 2-chamber/4-chamber views were analyzed. After correction for breathhold-related misregistration, 3D myocardial boundaries were fitted to images and edited by an imaging cardiologist. Myocardial thickness was quantified at end-diastole and end-systole by computing the 3D distances using Laplace's equation. 3D thickening was represented using the standard 17-segment polar coordinates. 3D thickening was compared with 3D wall motion and with expert visual scores (6-point visual scoring of wall motion and wall thickening; 0 ¼ normal; 5 ¼ greatest abnormality) assigned by imaging cardiologists.Results: Correlation between ejection fraction and thickening measurements was (r ¼ 0.84; P < 0.001) compared to correlation between ejection fraction and motion measurements (r ¼ 0.86; P < 0.001). Good negative correlation between summed visual scores and global wall thickening and motion measurements were also obtained (r thick ¼ À0.79; r motion ¼ À0.74). Additionally, overall good correlation between individual segmental visual scores with thickening/wall motion (r thick ¼ À0.69; r motion ¼ À0.65) was observed (P < 0.0001).Conclusion: 3D quantitative regional thickening and wall motion measures obtained from MRI correlate strongly with expert clinical scoring.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Quantification of 3D regional myocardial wall thickening from gated magnetic resonance images

Prasad

Rauthan

Kavanagh

et al. 2010

Magnetic Resonance Imaging

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“…In recent years, there has been a growing interest in modeling chronic ischemia‐reperfusion injury percutaneously in Yucatan miniature pigs . Preclinical large animal models have long been the cornerstone of development and validation of heart failure treatments.…”

Section: Introductionmentioning

confidence: 99%

Multiparametric CMR imaging of infarct remodeling in a percutaneous reperfused Yucatan mini‐pig model

et al. 2017

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Purpose To further understanding of the temporal evolution and pathophysiology of adverse ventricular remodeling over the first 60 days following a myocardial infarction (MI) in both the infarcted and remote myocardium, we performed multi-parametric cardiac magnetic resonance imaging (CMR) in a closed-chest chronic Yucatan mini-pig model of reperfused MI. Methods Ten animals underwent 90 minute left anterior descending artery occlusion and reperfusion. Three animals served as controls. Multiparametric CMR (1.5T) was performed at baseline, day-2, day-30 and in four animals at day-60 post-MI. Left ventricular volumes and infarct size were measured. T1 and T2 Mapping sequences were performed to measure values in the infarct and remote regions. Remote region collagen fractions were compared between infarcted animals and controls. Results Procedure success was 80%. The model created large infarcts (28 ± 5% of left ventricular mass on day-2), which led to significant adverse myocardial remodeling that stabilized beyond 30 days. Native T1 values did not reliably differentiate remote and infarct regions acutely. There was no evidence of remote fibrosis as indicated by partition coefficient and collagen fraction analyses. The infarct T2 values remained elevated up to 60 days post-MI. Conclusion Multiparametric CMR in this model showed significant adverse ventricular remodeling 30 days post-MI similar to that seen in humans. In addition, this study demonstrated that remote fibrosis is absent and that infarct T2 signal remains chronically elevated in this model. These findings need to be considered when designing pre-clinical trials using CMR endpoints.

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“…Assessment of the LV regional wall motion and thickening plays an important role in the assessment of contractile cardiac function at rest, during stress-induced ischemia, and of its viability. [15][16][17][18] Methods to quantify wall motion can rely on detecting endocardial motion by observing image intensity changes, determining the boundary wall of the ventricle, or attempting to track anatomical myocardial landmarks. 19 Wall thickening (WT) is usually measured using centerlines, 15,16 which can be defined in terms of percentage of systolic thickening and calculated per landmark point as…”

Section: Introductionmentioning

confidence: 99%

Heart chambers and whole heart segmentation techniques: review

Kang

Woo

Slomka

et al. 2012

J. Electron. Imaging

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Abstract. Computer-aided segmentation of cardiac images obtained by various modalities plays an important role and is a prerequisite for a wide range of cardiac applications by facilitating the delineation of anatomical regions of interest. Numerous computerized methods have been developed to tackle this problem. Recent studies employ sophisticated techniques using available cues from cardiac anatomy such as geometry, visual appearance, and prior knowledge. In addition, new minimization and computational methods have been adopted with improved computational speed and robustness. We provide an overview of cardiac segmentation techniques, with a goal of providing useful advice and references. In addition, we describe important clinical applications, imaging modalities, and validation methods used for cardiac segmentation.

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Quantitative assessment of regional left ventricular function with cardiac MRI: Three‐dimensional centersurface method

Cited by 19 publications

References 24 publications

Quantification of 3D regional myocardial wall thickening from gated magnetic resonance images

Quantification of 3D regional myocardial wall thickening from gated magnetic resonance images

Multiparametric CMR imaging of infarct remodeling in a percutaneous reperfused Yucatan mini‐pig model

Heart chambers and whole heart segmentation techniques: review

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