“…These works deal with different strategies for approaching the segmentation task, including image-driven algorithms [10][11][12][13], probabilistic atlases [14,15], fuzzy clustering [16], deformable models [17][18][19], neural networks [20], active appearance models [21,22], anatomical-based landmarks [23], or level set and its variations [24,25]. A comprehensive review of techniques commonly used in cardiac image segmentation can be found in Kang et al [5]. Nevertheless, many published methods have various disadvantages for routine clinical practice: they are either computationally demanding [6,14,16,22], potentially unstable for subjects with pathology [25,26], limited to the left ventricle [11,24,25,27], require additional images to be acquired [28,29], or need complex shape and/or gray-level appearance models constructed (or 'learned') from many manually segmented images -which is labor intensive and of limited use due to both anatomical and image contrast inconsistencies [14,22,[26][27][28].…”