Quantitative assessment of macular microvasculature and radial peripapillary capillary plexus in the fellow eyes of patients with retinal vein occlusion using OCT angiography

Özçalışkan, Şehnaz; Özcan, Yasin

doi:10.1016/j.jfo.2020.06.004

Cited by 3 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 11 The diminished RPCD that was demonstrated probably represents the vascular regression accompanying the RNFL thinning and does not support the primary role of vascular insufficiency. Similarly, Ozcaliskan and Ozcan 12 also found that decreased macular vessel density in the outer ring, the peripapillary flux index, GC-IPL, and RNFL thicknesses in the fellow eyes of patients with RVO. In aforementioned studies, the patients had unilateral RVO and were not separated as BRVO or CRVO while this study included the patients with BRVO only.…”

Section: Discussionmentioning

confidence: 71%

“… 9 , 10 A recent study by Shin et al 11 revealed that the peripapillary microvascular density in the fellow eyes of unilateral RVO was decreased compared with control eyes. In addition, in a recent study, Ozcaliskan and Ozcan 12 also demonstrated microvascular changes in both macular and peripapillary regions of the unaffected fellow eyes of patients with unilateral RVO. In those studies, patients were not grouped as BRVO or CRVO.…”

Section: Introductionmentioning

confidence: 79%

“… 15 Wider foveal avascular zone, lower macular microvascular density, decreased peripapillary microvasculature, and lower perfusion of choriocapillaris in the fellow eyes of patients with unilateral RVO compared with healthy eyes have been detected in previous OCTA studies. 11 , 12 , 16 , 17 All these changes are based on the fact that underlying systemic vascular diseases may affect the retinal microcirculation of both eyes. The aim of this study was to evaluate RPCD in the unaffected fellow eyes of patients with BRVO specifically, as well as the affected eyes and compare them with age- and gender-matched healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the radial peripapillary capillary density in unilateral branch retinal vein occlusion and the unaffected fellow eyes

et al. 2022

View full text Add to dashboard Cite

Background: Given that unilateral branch retinal vein occlusion (BRVO) and glaucoma share common systemic vascular risk factors, the fellow eyes of patients with BRVO may be at increased risk of glaucoma. Objectives: To analyze the radial peripapillary capillary density (RPCD) in eyes with unilateral BRVO and their unaffected fellow eyes using optical coherence tomography angiography (OCTA). Design: Cross-sectional, prospective study. Methods: The study included 120 eyes of 80 patients: 40 affected eyes of BRVO, 40 fellow eyes of BRVO, and 40 control eyes. The RPCD, retinal nerve fiber layer thickness (RNFLT) were analyzed using OCTA. Results: RPCDs in the whole image, peripapillary region, all the hemispheres, and quadrants were statistically lower in the affected eyes than in both the fellow and control eyes ( p < 0.05 for all). RPCD values in the whole image and the peripapillary region were significantly lower in the fellow eyes than in the control eyes ( p = 0.013, and p = 0.021, respectively). RNFLTs in the peripapillary region, inferior hemisphere and inferior quadrant were significantly lower in the affected eyes than in the control eyes ( p < 0.05 for all). No significant differences were detected between the fellow eyes and the control eyes in term of RNFLT values in any regions ( p > 0.05 for all). Conclusion: Lower RPCD values despite similar RNFLT values were observed in the fellow eyes of patients with unilateral BRVO compared with healthy controls. These results may indicate the shared vascular mechanisms and risk factors that account for the development of BRVO and glaucoma.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of the radial peripapillary capillary density in unilateral branch retinal vein occlusion and the unaffected fellow eyes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Shin et al used the Cirrus HD-OCT 5000 with AngioPlex device to evaluate peripapillary microvascular parameters, and they found that the peripapillary vessel density and perfusion density as well as RNFL thickness were decreased in RVO fellow eyes [ 28 ]. In addition to this, Ozcaliskan et al also used the Cirrus HD-OCT 5000 with AngioPlex device to assess macular microvasculature and RPC plexus in RVO fellow eyes, and they concluded that the presence of RVO might be related to retinal microvasculature changes in both the macular and peripapillary regions of the fellow eyes [ 29 ]. In our study, RPC density was evaluated using a different OCTA devices (AngioVue RTVue XR Avanti), and consistent with the two studies, we found lower RPC densities in the fellow eyes than in normal controls in the average, inferior-hemisphere, nasal quadrant, and temporal quadrant measurements, similar to the decreases observed in RNFL thinning.…”

Section: Discussionmentioning

confidence: 99%

Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes

et al. 2021

View full text Add to dashboard Cite

Background To evaluate the radial peripapillary capillary (RPC) density in the fellow eyes of unilateral retinal vein occlusion (RVO) patients using optical coherence tomography angiography (OCTA), and further analyze the correlation between RPC density and peripapillary retinal nerve fiber layer (RNFL) thickness. Methods Seventy-eight unilateral RVO patients and 70 normal controls were included in the study. OCTA was conducted with the 4.5 × 4.5-mm scan pattern centered on the optic nerve head, and the RPC density and peripapillary RNFL thickness were quantified. Results The peripapillary RNFL in the RVO fellow eyes was significantly thinner than in normal controls in the average, inferior-hemisphere, inferior quadrant, and temporal quadrant (P < 0.05, respectively). The RPC density in the fellow eyes was also significantly lower in the average, inferior-hemisphere, nasal quadrant, and temporal quadrant ((P < 0.05, respectively). There were no significant differences in RNFL thickness and RPC density between branch RVO fellow eyes and central RVO fellow eyes. Pearson’s correlation analysis showed significant positive correlations between the RPC density and RNFL thickness in all measurements (P < 0.001, respectively). Conclusions The regional RPC density was reduced in the RVO fellow eyes, which might contribute to peripapillary RNFL thinning in the corresponding region, suggesting the influence of systemic risk factors on RVO. OCTA may offer new insights into the pathophysiology of RVO.

show abstract

Quantitative Assessment Parameters of Peripapillary Regions with Branch Retinal Vein Occlusion by Using Optical Coherence Tomography Angiography

Yin

Cui

Jiao

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Purpose. To investigate the baseline parameters of peripapillary regions in both eyes of patients with unilateral branch retinal vein occlusion (BRVO) using optical coherence tomography angiography (OCTA) and their association with best-corrected visual acuity (BCVA). Methods. Forty-eight unilateral BRVO patients were enrolled. The 4.5 × 4.5 mm disc angiogram was acquired in the BRVO eyes and fellow eyes using the OCTA. Radial peripapillary capillary (RPC), whole vessel density, and retinal nerve fiber layer (RNFL) thickness in different regions and optic nerve head (ONH) analysis were automatically calculated. The partition includes the whole image, peripapillary, superior hemifield, inferior hemifield, eight equally divided sectors, and nine evenly divided square areas. Results. All vessel density and capillary vessel density in the whole and peripapillary regions of BRVO eyes were significantly lower than those in fellow eyes. The RNFL peripapillary thickness in BRVO eyes was significantly higher than those in fellow eyes. In eyes with supertemporal vein occlusion, all vessel density both in the superior hemifield and in the G12 region was significantly reduced compared with that in the fellow eyes. The capillary vessel density was significantly lower in the superior hemifield, superior temporal (ST), superior nasal (SN), and temporal superior (TS) areas than in the fellow eyes. The RNFL thickness in the NI, IN, TI, and TS sectors was significantly higher than in fellow eyes (all P < 0.05 ). Conclusions. OCTA provided quantitative information on peripapillary vascular density and RNFL thickness changes in BRVO. Branch retinal vein occlusion not only affects the blood vessel density in the macular area but also decreases the radial peripapillary capillaries. The capillary density is mainly affected in the affected hemifield but not in the unaffected hemifield.

show abstract

Quantitative assessment of macular microvasculature and radial peripapillary capillary plexus in the fellow eyes of patients with retinal vein occlusion using OCT angiography

Cited by 3 publications

References 22 publications

Evaluation of the radial peripapillary capillary density in unilateral branch retinal vein occlusion and the unaffected fellow eyes

Evaluation of the radial peripapillary capillary density in unilateral branch retinal vein occlusion and the unaffected fellow eyes

Patients with unilateral retinal vein occlusion show reduced radial peripapillary capillary density in their fellow eyes

Quantitative Assessment Parameters of Peripapillary Regions with Branch Retinal Vein Occlusion by Using Optical Coherence Tomography Angiography

Contact Info

Product

Resources

About