Quantitative assessment of lncRNA HOTAIR polymorphisms and cancer risk in Chinese population: a meta-analysis based on 26,810 subjects

Abstract

As a well-known long non-coding RNA, HOTAIR has been demonstrated to be involved in carcinogenesis and progression of various human cancers. Previous studies have investigated the potential association between HOTAIR polymorphisms and cancer risk in Chinese population. However, the results remain conflicting. Therefore, for the first time, we conducted a meta-analysis to derive a more precise estimation of these associations for Chinese. PubMed, Embase, CNKI and Wanfang databases were systematically searched. Odds ratios with 95% confidence intervals were applied to assess the association between rs920778, rs4759314, rs7958904, rs874945 and rs1899663 polymorphisms of HOTAIR and cancer susceptibility. Heterogeneity, sensitivity analysis and publication bias were conducted to measure the robustness of our findings. A total of 21 eligible studies comprising 12,278 cases and 14,532 controls were analyzed. The pooled data showed that rs920778 polymorphism was significantly associated with an increased cancer risk in all five genetic models in Chinese population. As for rs4759314 and rs874945 polymorphisms, similarly increased risks were found in specific genetic models and stratified groups. However, significant decreases in cancer risk were observed for rs7958904 in the total population, as well as in subgroup analyses. In addition, lack of association was detected between rs1899663 polymorphism and cancer susceptibility. In summary, our meta-analysis implicates possible relationship between HOTAIR polymorphisms and cancer risk in Chinese population.

A systematic review and meta-analysis of the association between HOTAIR polymorphisms and susceptibility to breast cancer

“…Arch Med Sci [32]. Li's meta-analysis revealed a significant association between HOTAIR rs4759314 and susceptibility to breast cancer; however, we failed to corroborate that in our meta-analysis [34].…”

“…Emerging studies have concentrated on links between HOTAIR polymorphisms (rs1899663, rs4759314, rs920778 and rs12826786) and cancer risk. Meanwhile, several meta-analyses investigated the relations of HOTAIR polymorphisms and cancer risk [27][28][29][30][31][32][33]; however, none of them have focused on the breast cancer risk independently due to lack of eligible data and some results remain confusing. For example, Qi et al reported that the HOTAIR rs920778 polymorphism increased cancer risk under allele and recessive models in overall analyses while Tian et al failed to observe significant associations between them 8…”

Genetic impacts on thermostability of onco-lncRNA HOTAIR during the development and progression of endometriosis

“…The most frequently studied functional SNPs include genetic variations at the intron enhancer region, such as rs4759314-G allele and rs920778-T allele, which showed transcription-promoting activity, leading to increased total HOTAIR levels [ 38 , 39 ]. Another intron variant, rs1899663-A allele, had a significantly increased cancer risk [ 40 ], whereas the SNP within the exon region, rs7958904-C allele, was found to play a protective role against cancer [ 41 ]. To date, the detail mechanisms associated with such substitutions in cancer development are still unclear.…”

Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis

“…It is known to all that over 20 lncRNA polymorphisms are associated with susceptibility of cancer. In recent studies, most of meta-analyses were conducted to focus on the association between lncRNA HOTAIR [ 27 , 28 ] or lncRNA ZNRD1-AS1 [ 28 ] or lncRNA POLR2E [ 29 ] or lncRNA H19 [ 28 , 30 ] polymorphisms and cancer risk. For example, the study of Lv et al [ 28 ] included only four common lncRNA genes such as H19, HOTAIR, ZNRD1-AS1 , and PRNCR1 .…”