Association between long non-coding RNA polymorphisms and cancer risk: a meta-analysis

Abstract

Several studies have suggested that long non-coding RNA (lncRNA) gene polymorphisms are associated with cancer risk. In the present study, we conducted a meta-analysis related to studies on the association between lncRNA single-nucleotide polymorphisms (SNPs) and the overall risk of cancer. A total of 12 SNPs in five common lncRNA genes were finally included in the meta-analysis. In the lncRNA antisense non-coding RNA (ncRNA) in the INK4 locus (ANRIL), the rs1333048 A/C, rs4977574 A/G, and rs10757278 A/G polymorphisms, but not rs1333045 C/T, were correlated with overall cancer risk. Our study also demonstrated that other SNPs were correlated with overall cancer risk, namely, metastasis-associated lung adenocarcinoma transcript 1 (MALAT1, rs619586 A/G), HOXA distal transcript antisense RNA (HOTTIP, rs1859168 A/C), and highly up-regulated in liver cancer (HULC, rs7763881 A/C). Moreover, four prostate cancer-associated ncRNA 1 (PRNCR1, rs16901946 G/A, rs13252298 G/A, rs1016343 T/C, and rs1456315 G/A) SNPs were in association with cancer risk. No association was found between the PRNCR1 (rs7007694 C/T) SNP and the risk of cancer. In conclusion, our results suggest that several studied lncRNA SNPs are associated with overall cancer risk. Therefore, they might be potential predictive biomarkers for the risk of cancer. More studies based on larger sample sizes and more lncRNA SNPs are warranted to confirm these findings.

Association Between LncRNA MALAT1 Polymorphisms and Cancer Risk: A Meta-Analysis Based on7007 Cases and 8791 Controls

“…In addition, MALAT1 induced EMT and suppressed cell apoptosis via Wnt/β-catenin signaling pathway [40]. Consistent with one previous meta-analysis including 2 studies for rs619586 [41], we found it was associated with decreased cancer risk in all populations. Nonetheless, no association was found between rs619586 and melanoma risk [29].…”

Long non‐coding RNAs in cancer: Another layer of complexity

“…Although few examples of lncRNAs are currently used in clinical practice, the list of potential biomarkers is large for almost all cancer types (Table ). For example, there are numerous descriptions associating polymorphisms, mainly single nucleotide polymorphisms (SNPs), with potential predictive biomarkers for the risk of cancer, including SNPs in ANRIL , MALAT1 , HOXA , HULC and PRNCR1 …”

“…For example, there are numerous descriptions associating polymorphisms, mainly single nucleotide polymorphisms (SNPs), with potential predictive biomarkers for the risk of cancer, including SNPs in ANRIL, MALAT1, HOXA, HULC and PRNCR1. 162,163 Considering RNA expression, several lncRNAs were associated with stage, prognosis and chemotherapy resistance in many different tumor types. 164 Beyond the detection of lncRNAs deregulated in tumor tissues, these molecules have been analyzed in body fluids (whole blood, plasma, urine, gastric juice and saliva) ( Table 2), suggesting possible non-invasive and more convenient methods that are easily clinically acceptable.…”

Characterization of lncRNA LINC00520 and functional polymorphisms associated with breast cancer susceptibility in Chinese Han population

“…The expression of the same lncRNA transcripts varies by different health conditions, age, tissues, even cells, which can indicate their potential as possible biomarkers and be predictive of diagnosis and prognosis of diseases . Enormous studies have proven that lncRNAs were associated with tumorgenesis, progression, metastasis, and drug resistance, functioning as oncogenes, tumor suppressor genes, or both, involving in shaping multiple biological characteristics of cancer at transcriptional, posttranscriptional, and epigenetic levels . In addition, the abnormal expression levels of different lncRNAs with oncogenic and tumor suppressor functions have been frequently found in the development of BC .…”

“…8,9 Enormous studies have proven that lncRNAs were associated with tumorgenesis, progression, metastasis, and drug resistance, functioning as oncogenes, tumor suppressor genes, or both, involving in shaping multiple biological characteristics of cancer at transcriptional, posttranscriptional, and epigenetic levels. [10][11][12] In addition, the abnormal expression levels of different lncRNAs with oncogenic and tumor suppressor functions have been frequently found in the development of BC. 13 Particularly, adverse rules of miRNAs-sponging ln-cRNAs, involved in ceRNA networks (ceRNETs), have been shown in BC.…”