Quantitative assessment of hsp70, IL-1β and TNF-α in the spinal cord of dogs with E40K SOD1-associated degenerative myelopathy

Canine degenerative myelopathy: a model of human amyotrophic lateral sclerosis

“…In particular, glial activation and reactive astrocytosis could be initiated by pro-inflammatory mediators that are secreted by MNs in response to injury, axotomy or muscular pathology (Barbeito et al, 2004;Lovett et al, 2014). In a recent study, Lovett and colleagues aimed at determining whether an inflammatory phenotype is present in CDM (Lovett et al, 2014).…”

Heat shock proteins: a therapeutic target worth to consider

“…Though the studies have shown that overexpression of HSP60 induces the secretion of interleukin 6 (IL-6) from human monocytes via signaling through CD 14 and p38 MAPK, along with the enhanced expression of TNF-α and nitric oxide. It also induces the expression of a range of cytokines, including IL-12 and IL-15 [ 39 - 41 ]. Mammalian HSP60 has been proved as a key target for T cell and Ab responses in chronic inflammation and atherosclerosis [ 42 ].…”

“…Bacterial HSPs have shown to enhance the expression of intracellular cell adhesion molecule and vascular cell adhesion molecule. HSP70 acts through a CD14-dependent pathway to stimulate IL-1, IL-6 and TNF-α production, indicating the fact that HSPs are directly involved in the inflammation [ 41 ].…”

Grand Challenge Veterinary Neurology and Neurosurgery: Veterinary Neurology and Neurosurgery – Research for Animals and Translational Aspects

“…Genetic analysis and DNA testing in veterinary neurology are new and powerful tools that already have elucidated several rare diseases ( 26 ). Additionally, animals with naturally occurring diseases can serve as useful animal models ( 27 , 28 ) or enlighten the genetic background of fundamental blueprints, such as that which determines the number of cervical vertebrae in an animal ( 29 ). In this study, a bovine mutation model with clinical and pathological spinal cord disease revealed information about the complex processes occurring during vertebral development.…”