Quantitative assay of metronidazole by capillary zone electrophoresis with amperometric detection at a gold microelectrode

Jin, Wenrui; Li, Wei; Xu, Qian

doi:10.1002/(sici)1522-2683(20000401)21:7<1409::aid-elps1409>3.0.co;2-0

Cited by 37 publications

(11 citation statements)

References 22 publications

(12 reference statements)

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“…In case of determinations with cationic polarization, such interferences should be taken into account and hence, e.g. in determination of the metromidazole drug with cathodic detection with a gold microelectrode a deaeration injector and a deaeration protector of the detector cell were used [184]. Amperometric detection in non-aqueous conditions with the use as the BGE solution of acetic acid and sodium acetate in acetonitrile was reported for determination of nicotine in tobacco extracts [185].…”

Section: Amperometric Detection In Capillary Electrophoresismentioning

confidence: 99%

Recent developments in electrochemical flow detections—A review

Trojanowicz

2009

Analytica Chimica Acta

129

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Section: Amperometric Detection In Capillary Electrophoresismentioning

confidence: 99%

Recent developments in electrochemical flow detections—A review

Trojanowicz

2009

Analytica Chimica Acta

129

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“…Using fluorescently labelled carbonic anhydrase II and a charged competitive ligand that was added to the running buffer, the glaucoma drug dorzolamide could be determined in fortified urine and plasma with a detection limit of 62.5 pM via distinction between the dorzolamide-carbonic anhydrase II complex and free carbonic anhydrase II. In the covered time period, quite a large number of papers appeared reporting the use of electrochemical drug detection after CZE separation, including those for analysis of urinary promethazine and thioridazine at a carbon microdisk array electrode [118], chloramphenicol in plasma with a carbon microdisk array electrode [119], metronidazole in urine employing a gold microelectrode [120], caffeine in serum using a carbon microdisk array electrode [121], and daunorubicin in urine at a carbon disk electrode [122]. In all these papers, body fluids fortified with the drug and not clinical samples were analyzed.…”

Section: Drugs In Biofluids and Tissuesmentioning

confidence: 99%

Advances of capillary electrophoresis in clinical and forensic analysis (1999-2000)

et al. 2001

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In this paper, capillary electrophoresis in clinical and forensic analysis is reviewed on the basis of the literature of 1999, 2000 and the first papers in 2001. An overview of progress relevant examples for each major field of application, namely (i) analysis of drug seizures, explosives residues, gunshot residues and inks, (ii) monitoring of drugs, endogenous small molecules and ions in biofluids and tissues, (iii) general screening for serum proteins and analysis of specific proteins (carbohydrate deficient transferrin, alpha1-antitrypsin, lipoproteins and hemoglobins) in biological fluids, and (iv) analysis of nucleic acids and oligonucleotides in biological samples, including oligonucleotide therapeutics, are presented.

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“…CE-LIFD has been used for the other type of screening, such as carbohydrates in urine, cancer screening in urine [92,93], even for selective detection of unusual substances as bacterial enterotoxins [94]. Some other prescription drugs such as cloramphenicol, clozapine, and metronidazol, and body proteins, such as myoglobin have been analyzed by CE-EC in human blood or urine [95][96][97][98]. The monitoring of plasma levels of antineoplasic drugs in pediatric patients is done by CE analysis of capillary blood samples [99].…”

Section: Pharmaceutical Clinical and Forensic Applicationsmentioning

confidence: 99%

Biomedical applications of capillary electrophoresis with laser‐induced fluorescence detection

Páez

Hernández

2001

Biopharm & Drug Disp

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Capillary electrophoresis (CE) is a high-efficiency analytical technique that has had a great impact as a tool in biomedical research, clinical and forensic practice in the last ten years. Only in one of the applications, the DNA analysis, it has had an explosive exponential growth in the last few years. This impact is expressed in an enormous amount of CE articles and many reviews. The CE advantages with respect to other analytical techniques: the required very small sample volume, rapid analysis, great resolution power and low costs, have made this technique ideal for the analysis of a numerous endogenous and exogenous substances present in biological fluids. The different modes of CE have been coupled to different detection techniques such as UV-absorbance, electrochemical, mass spectrometry and laser-induced fluorescence detection (LIFD) to detect different nature and molecular size separated analytes. This review focuses mostly on the applications of CE-LIFD, to measure drugs and endogenous neuroactive substances such as amino acids and monoamines, especially in microdialysis samples from experimental animals and humans. CE-LIFD trends are discussed: automated faster analysis with capillary array systems, resolution power improvement, higher detection sensitivity, and CE systems miniaturization for extremely small sample volume, in order to make CE easier and affordable to the lab bench or the clinical bed.

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Quantitative assay of metronidazole by capillary zone electrophoresis with amperometric detection at a gold microelectrode

Cited by 37 publications

References 22 publications

Recent developments in electrochemical flow detections—A review

Recent developments in electrochemical flow detections—A review

Advances of capillary electrophoresis in clinical and forensic analysis (1999-2000)

Biomedical applications of capillary electrophoresis with laser‐induced fluorescence detection

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