Quantitative Apparent Diffusion Coefficient as a Noninvasive Imaging Biomarker for the Differentiation of Invasive Breast Cancer and Ductal Carcinoma In Situ

Bickel, Hubert; Pinker-Domenig, Katja; Bogner, Wolfgang; Spick, Claudio; Bagó-Horváth, Zsuzsanna; Weber, Michael; Helbich, Thomas H.; Baltzer, Pascal

doi:10.1097/rli.0000000000000104

Cited by 96 publications

(80 citation statements)

References 39 publications

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“…The results of the studies reported in the literature are inconsistent. The mean ADC values with very small differences were significant in some studies but not significant in others (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). Therefore, we believe large series with the participation of more patients are needed in this regard.…”

Section: Discussionmentioning

confidence: 99%

“…In the study by Choi et al (31), the threshold value for the Ki-67 value was considered as 20, when values over 20 were categorized as Ki-67(+) and values under 20 were (-), the ADC values of the tumors with high Ki-67 were significantly low. In a study by De Felice et al (37) of 75 patients with invasive ductal carcinoma, the threshold value for Ki-67 was 30.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have investigated the relationship between tumor prognostic factors and DWI (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). Some studies concluded that there was a relationship between tumor grade and ADC values.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Akın¹,

Uğurlu²,

Kaya³

et al. 2016

J Breasth Health

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IntroductionMagnetic resonance imaging (MRI) as a method for breast exams has been used increasingly frequently during the last decade. In particular, it is preferred for selected cases as a diagnostic and problem-solving method for its high contrast resolution, multiplanar capability of examination, lack of ionizing radiation, and capacity to obtain dynamic contrast images (1, 2). Conventional MRI has disadvantages such as time-consuming screening and requirement of high-value contrast agents (3). Despite the fact that dynamic contrast-enhanced MRI is an efficient diagnostic exam with high sensitivity, but its limited specificity creates a need for new techniques (1-7). Therefore, additional sequences are sought that would increase image quality, reduce imaging time and enable differential diagnosis for lesions (4). Diffusionweighted imaging (DWI) is one of these fast MRI sequences. By recording the free movement of water molecules in the extracellular space, DWI creates different signals in images as a result of the inhibition of this movement and therefore diffusion restriction, which occurs due to an increase in cell frequency in the presence of a malignant mass. The apparent diffusion coefficient (ADC) is a quantitative measure of the diffusion of water molecules within tissue. Using the data in various b-values obtained from DWI in MRI, ADC maps are created and ADC values of lesions can be calculated (8,9). Recent studies showed that DWI and ADC measurements had high rates of accuracy and specificity in the differential diagnosis of malignant and benign breast lesions (10-13).Breast cancer is a heterogeneous disease, and its natural course after diagnosis varies among patients. In the follow-up of patients with tumors of the same diameter, some experience tumor recurrence after a very short time, whereas others continue living a healthy life. Therefore, prognostic factors and molecular subgroups are used in order to determine differences between clinical and biologic behaviors of patients with breast cancer and establish the high-risk group, which demonstrates a quick disease progression (14-17). Although some of these factors (tumor diameter, axillary involvement, histologic characteristics of tumor, hormone receptors) have a well-known role in determining prognosis, there is ongoing intensive research regarding hormone receptors, tumor proliferation rate, and molecular prog- Breast Health 2016; 12: 123-132 DOI: 10.5152/tjbh.2016 12: 123-132 DOI: 10.5152/tjbh. .2897 123 ABSTRACT Objective: The aim of this study was to evaluate the effect of the apparent diffusion coefficient (ADC) and diffusion-weighted imaging in differentiating benign from malignant breast lesions, histopathologic subtypes of breast tumors, and to find a correlation with prognostic factors using 3T MR. Materials and Methods:A total of 165 patients aged between 16 and 78 years with 181 histopathologically-verifed breast lesions were enrolled in this study. A 3T MR system and bilateral phased array breast coil was used. Diffusion-weigh...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Akın¹,

Uğurlu²,

Kaya³

et al. 2016

J Breasth Health

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“…Therefore, masses are more common among invasive neoplasms, especially when portraying spiculated margin, strong initial enhancement followed by washout (Type 3 curve), or other suspicious descriptors, as we have shown in concordance to others 20 . The interest in DWI as a diagnostic and predictive surrogate biomarker for breast malignancy has increased in parallel to improvements in MRI technique [21][22][23] . In their preliminary results, Iima et al 23 have shown a strong negative correlation between ADC measurements and DCIS grade, with high specificity in discriminating low-grade lesions, in a series of 25 patients.…”

Section: Discussionmentioning

confidence: 99%

Simple magnetic resonance imaging criteria can differentiate ductal carcinomas in situ from invasive carcinomas

Almeida¹,

Gomes²,

Barros³

et al. 2015

Rev. Bras. Mastol.

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“…Bogner et al [20] verglichen unterschiedliche DWI-Schemata im Hinblick auf die Genauigkeit und Prä-zision des ADC-Werts und des DWIKontrast-zu-Rausch-Verhaltens für benigne und maligne Brustläsionen sowie gesundes Brustdrüsengewebe bei 3 T. In dieser Studie war bei 3 T eines DWIProtokolls mit den b-Werten 50 und 850 s/mm 2 eine optimale Bestimmung des ADC und eine exzellente Differenzierung zwischen benignen und malignen Tumoren möglich. Aktuelle Studien legen nahe, dass mit der DWI auch unterschiedliche biologische Subtypen und invasive von nichtinvasiven Mammakarzinomen unterschieden werden können [21]. Eine weitere vielversprechende Applikation der DWI ist die Therapieverlaufskontrolle [18].…”

Section: Mrt Der Brustunclassified

Multiparametrische und molekulare Bildgebung von Brusttumoren mit MRT und PET‑MRT

et al. 2016

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Hintergrund MRT der BrustQuantitative KM-MRT [6] erstmals die klinische Anwendbarkeit der bilateralen KM-MRT der Brust bei 7 T an Patientinnen mit Brusttumoren. Die Autoren der Studie kamen zu dem Schluss, dass die bilaterale KM-MRT der Brust bei 7 T klinisch anwendbar ist und eine Brustkrebsdiagnostik mit hoher diagnostischer Genauigkeit (96,6 %), einem ausgezeichnetem Interrateragreement und einer exzellenten Bildqualität ermöglicht. Gruber et al. [19] verglichen Bildqualität, Kontrastmittelanfärbever-halten und diagnostische Genauigkeit der bilateralen KM-MRT der Brust bei 7 und 3 T im selben Patientinnenkollektiv. Im Vergleich zu 3 T war eine signifikant bessere räumliche und zeitliche Auflösung möglich und es konnte eine exzellente Sensitivität und gute Spezifität von 100 und 91,67 % in der Brustkrebsdiagnostik erzielt werden. Diffusionsgewichtete BildgebungMit diffusionsgewichteten MR-Sequenzen("diffusion-weighted imaging", DWI) wird die zufällige Bewegung von Wassermolekülen nichtinvasiv im Gewebe gemessen. Die gemessene Diffusivität des untersuchten Gewebes stellt so einen Surrogatmarker für die Mikrostruktur und Zelldichte dar und wird durch den "apparent diffusion coefficient" (ADC)

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Quantitative Apparent Diffusion Coefficient as a Noninvasive Imaging Biomarker for the Differentiation of Invasive Breast Cancer and Ductal Carcinoma In Situ

Cited by 96 publications

References 39 publications

Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Diagnostic Value of Diffusion-weighted Imaging and Apparent Diffusion Coefficient Values in the Differentiation of Breast Lesions, Histpathologic Subgroups and Correlatıon with Prognostıc Factors using 3.0 Tesla MR

Simple magnetic resonance imaging criteria can differentiate ductal carcinomas in situ from invasive carcinomas

Multiparametrische und molekulare Bildgebung von Brusttumoren mit MRT und PET‑MRT

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