Quantitative and Qualitative Identification of Phytochemical Constituents of Sida Rhombifolia Leaves Extract

doi:10.35940/ijrte.b1078.0782s419

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Laportae aestuans however had the higher composition of phenolics (518.18±1.43). Some authors had investigated the presence of phytochemicals in S. rhombifolia [33,34,35]. In this study, S. rhombifolia were found to contain steroids, flavonoids, phenolics, alkaloids, terpenoids coumarins, triperpenoids, saponins and glycosides.…”

Section: Mineral Phytochemical and Heavy Metal Compositionmentioning

confidence: 97%

Intra Specific Relationships and Biochemical Composition of Laportea Aestuans (L.) Chew, Sida Rhombifolia L. And Commelina Verginica L. in Lagos State

E. Ani,

Ofodile,

Nwakanma

et al. 2023

Iraqi Journal of Science

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Laportea aestuans L. (Chew), Commelina virginica (L.) and Sida rhombifolia (L.) are common wild plants used in treating several ailments including diarrhea, dysentery, hernia, oedema, ulcers and many more in traditional African medicine especially, Nigeria. The potentials of Random Amplified polymorphic DNA (RAPD) primers in delimiting intra-specific variation in L. aestuans, C. virginica and S. rhombifolia was assessed using three RAPD primers. Plant and soil samples were collected from 19 local government areas in Lagos State and assessed for genetic and biochemical relationships. A total of 56 bands were produced of which 44 were polymorphic. Maximum number of bands (21) was produced by OPY20 while OPC04 produced minimum number of bands (14). The maximum and minimum percentage polymorphisms were 100% (OPC04) and 50% (OPA12), The dendrogram of genetic diversity had a genetic distance range of 0.57 to 1.00, 0.58 to 1.00 and 0.52 to 1.00 and clustered at 0.57, 0.58, 0.52 implying 57%, 58%, 52% similarity and 43%, 42% and 48% variability for L. aestuans, C. virginica and S. rhombifolia respectively. Results of phytochemical analysis show that S. rhombifolia is particularly high in steroids (I134.19±0.23), flavonoids (118.65±0.18), phenolics (125.25±1.43), alkaloids (63.56±0.11) and triterpenes (72.44±0.12) but low in saponins (23.29±0.05), glycosides (6.79±0.01) and tannins (7.10±0.02).

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Section: Mineral Phytochemical and Heavy Metal Compositionmentioning

confidence: 97%

Intra Specific Relationships and Biochemical Composition of Laportea Aestuans (L.) Chew, Sida Rhombifolia L. And Commelina Verginica L. in Lagos State

E. Ani,

Ofodile,

Nwakanma

et al. 2023

Iraqi Journal of Science

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“…Similarly, the phytoconstituents reported in fractions were summarized in Table 5 as per earlier reports. [22][23][24][25] Journal of Young Pharmacists, Vol 13 Issue 4, Oct-Dec, 2021…”

Section: In Vitro Ache Inhibitionmentioning

confidence: 99%

In silico and in vitro Approach To Identify Memory Enhancers from Sida rhombifolia L.

Pattanashetti¹,

Patil²,

Hegde³

2021

JYP

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Background: Sida rhombifolia L. is a well documented Ayurvedic medicine for the management of neurodegenerative diseases and to enhance cognitive function. Researchers demonstrated its activities under various animal model/s, but lack the probable molecular mechanism in the treatment of Alzheimer's disease. Current study was aimed to identify the acetylcholinesterase (AChE) inhibitory potency of phytocompounds and enriched fractions from S.rhombifolia using in vitro and network pharmacology approaches. Methods: Phytocompounds were retrieved from phytochemical databases, scientific reports and quired for druggability. Protein targets were predicted using BindingDB (p≥0.7). STRING database and KEGG pathway were utilized to perform gene set enrichment analysis and to identify the probable pathways modulated by the phytocompounds. Cytoscape v3.6.1 was used to construct a target-compound-pathway network. Docking was performed by PyRx 0.8v. Enriched fractions of S. rhombifolia were tested for in vitro AChE inhibitory potency using the AChE enzyme. Results: Among 35 compounds, 26 compounds showed positive drug likeness property. Out of 26 compounds, 9 compounds i.e. 2D-hydroxyecdysone, ecdysone, pterosterone-3-O-β-D-glucopyranoside, acacetin, kaempferol, sanguinine, vascicine, vasicinol, vasicinone were predicted to target AChE and other 9 therapeutic targets involved in Alzheimer's disease (AD). Acacetin scored lowest binding energy with AChE (-8.9kcal/mol). Among the selected enriched fractions, hexane fraction pertains highest AChE inhibition (IC 50 12.87µg/ml) compared to clinical approved drug Donepezil (IC 50 2.92µg/ml). Conclusion: The role of S.rhombifolia for the management of AD could be attributed due to the major effect of 2D-hydroxyecdysone, ecdysone, pterosterone-3-O-β-Dglucopyranoside, acacetin, kaempferol, sanguinine, vascicine, vasicinol, vasicinone on AChEand their action on multiple protein molecules associated with AD pathogenesis.

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Antimalarial potential of ethanol extract, and anti-inflammatory properties of flavonoid-, terpenoid-, and alkaloid-rich fractions of <i>Sida linifolia</i> L.

Nwankwo,

Ashiakpa

2024

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Quantitative and Qualitative Identification of Phytochemical Constituents of Sida Rhombifolia Leaves Extract

Cited by 3 publications

References 5 publications

Intra Specific Relationships and Biochemical Composition of Laportea Aestuans (L.) Chew, Sida Rhombifolia L. And Commelina Verginica L. in Lagos State

Intra Specific Relationships and Biochemical Composition of Laportea Aestuans (L.) Chew, Sida Rhombifolia L. And Commelina Verginica L. in Lagos State

In silico and in vitro Approach To Identify Memory Enhancers from Sida rhombifolia L.

Antimalarial potential of ethanol extract, and anti-inflammatory properties of flavonoid-, terpenoid-, and alkaloid-rich fractions of <i>Sida linifolia</i> L.

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