Quantitative Analysis of the Effect of Methylcobalamin on the Peripheral Nerve Structures in Experimental Diabetic Neuropathy

Yagihashi, Soroku; Nishihira, Morimi; Tokui, A.

doi:10.3999/jscpt.11.131

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Mecobalamin accelerates transmethylation in nerve tissues and increases biolytic synthesis of nucleic acids and phospholipids [12,13]. Its efficacy in experimental studies has been documented with regard to the regeneration of peripheral nerves that previously showed Wallerian degeneration [14], regeneration in acrylamid neuropathy [15], uremic neuropathy [16], segmental demyelination due to diabetic peripheral neuropathy [17], and axonal degeneration due to adriamycin neuropathy [18]. In clinical studies, the efficacy of mecobalamin has been reported in nerverelated diseases such as peripheral neuropathy associated with diabetic polyneuropathy [19,20].…”

Section: Introductionmentioning

confidence: 98%

RETRACTED: Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients

Satō

Honda

Iwamoto

et al. 2005

Journal of the Neurological Sciences

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Section: Introductionmentioning

confidence: 98%

RETRACTED: Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients

Satō

Honda

Iwamoto

et al. 2005

Journal of the Neurological Sciences

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“…These results suggest 3B improved impaired NCV without affecting the diabetes itself as suggested by Fukuda et al (7). Yagihashi et al (12) reported that the daily administration of methylcobalamin decreased the incidence of degenerated nerve fibers and suppressed the reduction of myelinated nerve fiber density in STZ diabetic rats. Ikeda et al (13) also reported that the atrophy of Schwann cells and the incidence of disintegration of the myelin sheath of sciatic nerves observed in alloxan diabetic rats were normalized by daily administration of vitamin B mixture.…”

mentioning

confidence: 99%

Effects of vitamin B mixture on neuropathy in streptozotocin-induced diabetic rats.

Sakitama

Saito

et al. 1989

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Vitamin B mixture, especially a mixture of B1, B6, and B12, provides beneficial effects when used for the clinical treatment of various types of neuropathy including that in diabetes (1). In diabetic neuropathy, a decrease in nerve conduction velocity (NCV), segmental demyelination in nerve fibers, and an impairment of Schwann cells are observed in peripheral nerves (2). In animal experiments, thickening and degeneration of the myelin sheath are observed in both alloxan and streptozotocin (STZ) diabetic rats, and this demyelination may result in the reduction of NCV observed in diabetic rats (3-5). NCV is used as a major diagnostic and therapeutic index for assessing the function of peripheral nerves in diabetic neuropathy. Iwata et al. (6) and Fukuda et al. (7) reported an ameliorating effect of vitamin B mixture (B1, B6, and B12) on the decrease in NCV in alloxan diabetic rats. However, there is little information concerning the effects of vitamin B mixture on STZ-induced diabetic neuropathy, which is considered the preferable model for studying severe diabetic peripheral neuropathy (8). Thus, we investigated the effects of daily administration of 3B (a mixture of thiamine disulfide, pyridoxal hydrochloride and aquocobalamin) on STZ-induced diabetic neuropathy using NCV as the index. In accordance with a previous report (9) which demonstrated the favorable effects of a high dose of 3B on neuropathy induced by acrylamide, we also adopted a relatively high dose of 3B.The experiments were carried out on 3 groups of male Sprague-Dawley rats (9 weeks old, n=14-19). A standard laboratory chow (CRF-1, Charles River) and tap water were always available. Daily intake of vitamin B1, B6, and B12 from the diet was approximately 1.5, 0.5, and 0.0075mg per rat, respectively. Two groups were made diabetic by intraveneous injection of 45mg/kg STZ (Sigma) dissolved in citrate buffer (pH 4.1) immediately before use. The third group received the citrate 95

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Clinical efficacy of intravenous plus oral mecobalamin in patients with peripheral neuropathy using vibration perception thresholds as an indicator of improvement

Yamane

Usui

Yamamoto

et al. 1995

Current Therapeutic Research

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Quantitative Analysis of the Effect of Methylcobalamin on the Peripheral Nerve Structures in Experimental Diabetic Neuropathy

Cited by 3 publications

References 7 publications

RETRACTED: Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients

RETRACTED: Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients

Effects of vitamin B mixture on neuropathy in streptozotocin-induced diabetic rats.

Clinical efficacy of intravenous plus oral mecobalamin in patients with peripheral neuropathy using vibration perception thresholds as an indicator of improvement

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