Clinical efficacy of intravenous plus oral mecobalamin in patients with peripheral neuropathy using vibration perception thresholds as an indicator of improvement

RETRACTED: Amelioration by mecobalamin of subclinical carpal tunnel syndrome involving unaffected limbs in stroke patients

“…Its efficacy in experimental studies has been documented with regard to the regeneration of peripheral nerves that previously showed Wallerian degeneration [14], regeneration in acrylamid neuropathy [15], uremic neuropathy [16], segmental demyelination due to diabetic peripheral neuropathy [17], and axonal degeneration due to adriamycin neuropathy [18]. In clinical studies, the efficacy of mecobalamin has been reported in nerverelated diseases such as peripheral neuropathy associated with diabetic polyneuropathy [19,20]. and leprous neuralgia [21].…”

A randomized, open labeled study comparing the serum levels of cobalamin after three doses of 500 mcg vs. a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy

“…It is well transported into nerve cell organelles and promotes nucleic acid and protein synthesis [ 23 ]. The efficacy of methylcobalamin has been documented in various experimental and clinical studies with respect to the regeneration of peripheral nerves in acrylamid neuropathy [ 24 ], uremic neuropathy [ 25 ], peripheral neuropathy associated with diabetic polyneuropathy [ 14 ] and leprous neuralgia [ 26 27 ]. All these effects come together in the effectiveness of methylcobalamin in peripheral neuropathies.…”

“…Methylcobalamin accounts for 90% of the total cobalamin level in the cerebrospinal fluid (CSF), suggesting its correlation with the nervous system and making it more appropriate for use in neuropathy associated with vitamin B12 deficiency rather than other analogues [ 13 ]. The major route of administration is oral, although it has been administered by means of an intramuscular injection [ 14 ]. Injectable methylcobalamin was registered as a 500 µg unit dose ampule and recommended in a regimen of one injection every other day.…”

In Vivo Real-Time Simultaneous Examination of Drug Kinetics at Two Separate Locations Using Boron-Doped Diamond Microelectrodes

“…The clinical dose for single administration of methylcobalamin is typically 500 μg or approximately 10 μg kg –1 . In this study, when a larger dose (10 mg kg –1 ) was intravenously injected into normal guinea pigs, the concentration in the cochlear perilymph of the ST never exceeded the LOD of the BDD microelectrodes (0.006–0.04 nM) (Figures and S10).…”