Quantitative analysis of serum α1-acid glycoprotein levels in normal and diabetic pregnancy

Honda, Masashi; Omori, Yasue; Minei, Satomi; Oshiyama, Toshiko; Shimizu, Meimi; Sanaka, Mayumi; Kohama, Tomoko; Nakabayashi, Masao; Hirata, Yoshihiro

doi:10.1016/0168-8227(90)90037-t

Cited by 15 publications

(12 citation statements)

References 21 publications

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“…The levels of AGP in our study are similar to those previously noted in studies of pregnant women [20–22], including another in Nepal [11]. In contrast to CRP, AGP normally decreases over pregnancy [10, 20], as our study also observed.…”

Section: Discussionsupporting

confidence: 91%

Inflammation throughout pregnancy and fetal growth restriction in rural Nepal

et al. 2019

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Maternal systemic inflammation during pregnancy may restrict embryo−fetal growth, but the extent of this effect remains poorly established in undernourished populations. In a cohort of 653 maternal−newborn dyads participating in a multi-armed, micronutrient supplementation trial in southern Nepal, we investigated associations between maternal inflammation, assessed by serum α1-acid glycoprotein and C-reactive protein, in the first and third trimesters of pregnancy, and newborn weight, length and head and chest circumferences. Median (IQR) maternal concentrations in α1-acid glycoprotein and C-reactive protein in the first and third trimesters were 0.65 (0.53–0.76) and 0.40 (0.33–0.50) g/l, and 0.56 (0.25–1.54) and 1.07 (0.43–2.32) mg/l, respectively. α1-acid glycoprotein was inversely associated with birth size: weight, length, head circumference and chest circumference were lower by 116 g (P = 2.3 × 10−6), and 0.45 (P = 3.1 × 10−5), 0.18 (P = 0.0191) and 0.48 (P = 1.7 × 10−7) cm, respectively, per 50% increase in α1-acid glycoprotein averaged across both trimesters. Adjustment for maternal age, parity, gestational age, nutritional and socio-economic status and daily micronutrient supplementation failed to alter any association. Serum C-reactive protein concentration was largely unassociated with newborn size. In rural Nepal, birth size was inversely associated with low-grade, chronic inflammation during pregnancy as indicated by serum α1-acid glycoprotein.

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Section: Discussionsupporting

confidence: 91%

Inflammation throughout pregnancy and fetal growth restriction in rural Nepal

et al. 2019

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“…Others have studied serum levels of orosomucoid during pregnancy with conflicting results. Honda et al measured S‐orosomucoid levels in all 3 trimesters, and found a decrease throughout pregnancy (17). Direct comparison to our results is difficult, as we are not informed of the exact weeks of measurement in their study.…”

Section: Discussioncontrasting

confidence: 58%

“…Different studies have determined serum orosomucoid levels in healthy pregnancies, but results are conflicting (16–18). One study compared serum sialomucins in healthy and pre‐eclamptic pregnancies, and found increased serum sialomucins in pre‐eclampsia with further increase in severe pre‐eclampsia (19).…”

Section: Introductionmentioning

confidence: 99%

Pre‐symptomatic increase in urine‐orosomucoid excretion in pre‐eclamptic women

Kronborg

Allen

Vittinghus

et al. 2007

Acta Obstet Gynecol Scand

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Pre-eclampsia is associated with a pre-symptomatic increase in the urine excretion of orosomucoid, and orosomucoid excretion precedes that of albumin. Orosomucoid excretion can probably be used as a prognostic tool in combination with other screening methods, and seems to be a more sensitive marker for evolving pre-eclampsia than albumin. Plasma orosomucoid is significantly increased late in pre-eclampsia. Thus, the increased excretion of orosomucoid must primarily originate from altered renal processing of orosomucoid.

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“…[27] Western blot and iTRAQ analyses supported the increased abundance of Apo A-I (28 kDa, pI 5.28) observed in DIGE spot 152b. Apo A-I is a component of the high density lipoprotein complex, transports cholesterol and protects low density lipoprotein from oxidative stress.…”

Section: Discussionmentioning

confidence: 81%

Maternal serum proteome changes between the first and third trimester of pregnancy in rural Southern Nepal

Scholl

Cole

Ruczinski³

et al. 2012

Placenta

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Characterization of normal changes in the serum proteome during pregnancy may enhance understanding of maternal physiology and lead to the development of new gestational biomarkers of health. In 23 Nepalese pregnant women who delivered at term two-dimensional difference in-gel electrophoresis (DIGE) was used to assess changes in relative protein abundance between paired serum samples collected in the first and third trimesters. One-hundred and forty-five of over 700 protein spots in DIGE gels (pI 4.2–6.8) exhibited nominally significant (p<0.05) differences in abundance across trimesters. Additional filtering using a Bonferroni correction reduced the number of significant (p<0.00019) spots to 61. Mass spectrometric analysis detected 38 proteins associated with gestational age, cytoskeletal remodeling, blood pressure regulation, lipid and nutrient transport, and inflammation. One new protein, pregnancy-specific β-glycoprotein 4 was detected. A follow-up isotope tagging for relative and absolute quantitation (iTRAQ) experiment of six mothers from the DIGE study revealed 111 proteins, of which 11 exhibited significant (p<0.05) differences between trimesters. Four of these proteins: gelsolin, complement C1r subcomponent, α-1-acid glycoprotein, and α-1B-glycoprotein also changed in the DIGE analysis. Although not previously associated with normal pregnancy, gelsolin decreased in abundance by the third trimester (p<0.01) in DIGE, iTRAQ and Western analyses. Changes in abundance of proteins in serum that are associated with syncytiotrophoblasts (gelsolin, pregnancy specific β-1 glycoprotein 1 and β-2-glycoprotein I) probably reflect dynamics of a placental proteome shed into maternal circulation during pregnancy. Measurement of changes in the maternal serum proteome, when linked with birth outcomes, may yield biomarkers for tracking reproductive health in resource poor settings in future studies.

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Quantitative analysis of serum α1-acid glycoprotein levels in normal and diabetic pregnancy

Cited by 15 publications

References 21 publications

Inflammation throughout pregnancy and fetal growth restriction in rural Nepal

Inflammation throughout pregnancy and fetal growth restriction in rural Nepal

Pre‐symptomatic increase in urine‐orosomucoid excretion in pre‐eclamptic women

Maternal serum proteome changes between the first and third trimester of pregnancy in rural Southern Nepal

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