Pre‐symptomatic increase in urine‐orosomucoid excretion in pre‐eclamptic women

Abstract

Pre-eclampsia is associated with a pre-symptomatic increase in the urine excretion of orosomucoid, and orosomucoid excretion precedes that of albumin. Orosomucoid excretion can probably be used as a prognostic tool in combination with other screening methods, and seems to be a more sensitive marker for evolving pre-eclampsia than albumin. Plasma orosomucoid is significantly increased late in pre-eclampsia. Thus, the increased excretion of orosomucoid must primarily originate from altered renal processing of orosomucoid.

Excretion patterns of large and small proteins in pre‐eclamptic pregnancies

“…We have previously shown that orosomucoid was excreted before albumin (9), and in the present study also before transferrin and IgG. The protein structure of orosomucoid is not solved, but based on molecular weight it is smaller than the other HMW proteins.…”

“…Determination of other protein excretion patterns can help us to understand more about the underlying renal pathology in PE. We have previously shown that the small, negatively charged protein orosomucoid was excreted before albumin in PE pregnancies (9). To learn more about the renal changes in PE and healthy pregnancies, we analysed the protein excretion pattern of the high molecular weight (HMW) proteins immunoglobulin G (IgG) and transferrin and the low molecular weight (LMW) proteins α1‐ and β2‐microglobulins at six different time intervals from the 18th week of pregnancy until delivery.…”

Novel Biomarkers for Predicting Preeclampsia

“…In addition to studies mentioned above, novel biomarkers such as urine orosomucoid, an acute phase protein, show promise in early prediction of preeclampsia (Kronborg et al 2007). To date, however, studies of potential biomarkers for predicting preeclampsia have involved relatively small numbers of patients, although many of the studies have ambiguous definitions of preeclampsia and unclear distinction of early and severe disease.…”

Elevated levels of protein AMBP in cerebrospinal fluid of women with preeclampsia compared to normotensive pregnant women

“…Alpha-1-acid glycoprotein is an acute phase protein that increases during inflammation and protects the endothelium. It was previously identified as a predictive biomarker for PE in urine [37,38]. Alpha-1-acid glycoprotein is constitutively expressed by human microvascular endothelial cells [39]).…”