Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure

Ha, Ahnul; Kim, Tai Jun; Lee, Won June; Kim, Dong‐Myung; Jeoung, Jin Wook; Kim, Young Kook; Park, Ki Ho

doi:10.1007/s10384-019-00704-4

Cited by 3 publications

(2 citation statements)

References 29 publications

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“…Similar results had been elaborated by Tong YX in which inferior RNFLT defects had also been reported in the POAG cases. 16 Worldwide it has been proven that the severity of POAG is correlated with progressive loss of retinal ganglion cells, and subsequently the overall thickness of retinal deteriorates. Similar ndings can also be interrelated from our study with other research works.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Lamina Cribrosa Anatomical Parameters with Retinal Nerve Fiber Layer Thickness Defects In Primary Open-angle Glaucoma Cases And Controls

Naz

Qamar

Surti

et al. 2023

J Gandhara Med Dent Sci

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OBJECTIVES To assess the lamina cribrosa (LC) anterior lamina cribrosa depth (ALCD), lamina cribrosa thickness (LCT) and retinal nerve fiber layer thickness (RNFLT) in primary open-angle glaucoma (POAG) cases and age-matched controls and to compare these anatomical variables among POAG cases and age-matched controls. METHODOLOGY The case-control study was researched at Al-Ain Eye Institute, Karachi, in four month’s duration (November 2018 till February 2019). Expert eye specialist recruited 57 POAG cases and 46 age-matched healthy controls. Observation of intraocular pressure (IOP) and open angle was done using Goldmann tonometry and Slit-lamp biomicroscopy with stereoscopic ophthalmoscopy respectively. Visual field parameters of mean deviation (MD) and pattern standard deviation (PSD) measured using Humphrey Field Analyzer. Highly sensitive spectral domain ocular coherence tomography with enhanced depth imaging (EDI-OCT) was used to determine ALCD, LCT and RNFLT. RESULTS Statistically significant results were produced by RNFLT defects when it is compared in groups of mild with moderate cases of POAG (P-value 0.037). ALCD and LCT did display an association with RNFLT defects but did not produced statistically significant results. CONCLUSION Assessments of ALCD and LCT can provide important prognostic evidence about RNFLT and can assist in future planning of mild and moderate cases suffering from POAG.

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Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Lamina Cribrosa Anatomical Parameters with Retinal Nerve Fiber Layer Thickness Defects In Primary Open-angle Glaucoma Cases And Controls

Naz

Qamar

Surti

et al. 2023

J Gandhara Med Dent Sci

View full text Add to dashboard Cite

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“…For example, Kim et al 11 found that low‐tension glaucoma patients with intraocular pressure at or below 15 mm Hg demonstrated localised retinal nerve fibre layer defects closer to the macula compared with high‐teen levels, thus suggesting a different clinical presentation. Similarly, Ha et al 12 found that patients with lower intraocular pressure tended to have localised retinal nerve fibre layer defects closer to the macula, compared with patients with relatively higher intraocular pressure. Xu et al 13 described some differences in structural deficits between glaucoma groups in the peripapillary region, but interestingly no significant difference in the parafoveal region.…”

Section: Introductionmentioning

confidence: 92%

Visualising structural and functional characteristics distinguishing between newly diagnosed high‐tension and low‐tension glaucoma patients

Rafla

Khuu

Kashyap

et al. 2023

Ophthalmic Physiologic Optic

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Purpose To determine whether there are quantifiable structural or functional differences that can distinguish between high‐tension glaucoma (HTG; intraocular pressure [IOP] > 21 mm Hg) and low‐tension glaucoma (LTG; IOP ≤ 21 mm Hg) at diagnosis. Method This was a retrospective, cross‐sectional study. Clinical results of one eye from 90 newly diagnosed HTG and 319 newly diagnosed LTG patients (117 with very‐low‐tension glaucoma [vLTG; ≤15 mm Hg] and 202 with middling LTG [mLTG; >15 mm Hg, ≤21 mm Hg]) were extracted, which included relevant demographic covariates of glaucoma, quantitative optical coherence tomography (including the optic nerve head, retinal nerve fibre layer and ganglion cell‐inner plexiform layer) measurements and standard automated perimetry global metrics. We used binary logistic regression analysis to identify statistically significant clinical parameters distinguishing between phenotypic groups for inclusion in principal component (PC) (factor) analysis (PCA). The separability between each centroid for each cohort was calculated using the Euclidean distance (d(x,y)). Results The binary logistic regression comparing HTG and all LTG identified eight statistically significant clinical parameters. Subsequent PCA results included three PCs with an eigenvalue >1. PCs 1 and 2 accounted for 21.2% and 20.2% of the model, respectively, with a d(x,y) = 0.468, indicating low separability between HTG and LTG. The analysis comparing vLTG, mLTG and HTG identified 15 significant clinical parameters, which were subsequently grouped into five PCs. PCs 1 and 2 accounted for 24.1% and 17.8%, respectively. The largest separation was observed between vLTG and HTG (d(x,y) = 0.581), followed by vLTG and mLTG (d(x,y) = 0.435) and lastly mLTG and HTG (d(x,y) = 0.210). Conclusion Conventional quantitative structural or functional parameters could not distinguish between pressure‐defined glaucoma phenotypes at the point of diagnosis and are therefore not contributory to separating cohorts. The overlap in findings highlights the heterogeneity of the primary open‐angle glaucoma clinical presentations among pressure‐defined groups at the cohort level.

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Association of dipping status of blood pressure, visual field defects, and retinal nerve fiber layer thickness in patients with normotensive glaucoma

et al. 2020

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The aim of this study was to evaluate the association between dipping status of blood pressure (BP), visual field defects (VFDs), and retinal nerve fiber layer (RNFL) thickness in patients with normotensive glaucoma (NTG). Our University echocardiography, electrocardiogram, 24-hour BP monitor and glaucoma database were reviewed from 2016 to 2018 to identify patients with NTG and hypertension (HTN). These NTG patients were followed for a mean 26.4 ± 13.6 months and were divided into 2 groups according to the absence or presence of VFDs. Among the 110 patients with NTG, 55 (50%) patients had VFDs. There were no differences of baseline characteristics between 2 groups. In univariate analysis, extreme dipper status at night in the 24-hour BP monitoring, HTN, age, diabetes mellitus, and hyperlipidemia were significantly associated with VFDs. In multivariate analysis, extreme dipper status at night in the 24-hour BP monitoring (odds ratio [OR] 4.094; P = .045) and HTN (OR 2.368; P = .048) were independent risk factors for VFDs at 2-year follow-up. Moreover, the RNFL thickness was thinner in NTG patients with VFDs ( P < .001). VFDs group had more increased fluctuation of systolic and diastolic BP in 24-hour BP monitoring and that the extreme dipper status at night in the 24-hour BP monitoring and HTN itself were also associated with higher incidence of VFDs and thinning changes of the RNFL in patients with NTG, suggesting that more intensive medical therapy with close clinical follow-up will be required for these patients.

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Quantitative analysis of retinal nerve fiber layer defect in early open-angle glaucoma with normal intraocular pressure

Cited by 3 publications

References 29 publications

Comparative Evaluation of Lamina Cribrosa Anatomical Parameters with Retinal Nerve Fiber Layer Thickness Defects In Primary Open-angle Glaucoma Cases And Controls

Comparative Evaluation of Lamina Cribrosa Anatomical Parameters with Retinal Nerve Fiber Layer Thickness Defects In Primary Open-angle Glaucoma Cases And Controls

Visualising structural and functional characteristics distinguishing between newly diagnosed high‐tension and low‐tension glaucoma patients

Association of dipping status of blood pressure, visual field defects, and retinal nerve fiber layer thickness in patients with normotensive glaucoma

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