Quantitative analysis of piroxicam polymorphs pharmaceutical mixtures by hyperspectral imaging and chemometrics

Rocha, Wérickson Fortunato de Carvalho; Sabin, Guilherme P.; Março, Paulo Henrique; Poppi, Ronei J.

doi:10.1016/j.chemolab.2010.04.015

Cited by 73 publications

(29 citation statements)

References 24 publications

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“…In previous studies, the average [28]-or median [29]-spectra of the unfolded data cube were used to build calibration models. In this study, the spectra with the highest correlation to the median spectrum (corr-spec) of the data cube of every image were selected.…”

Section: Discussionmentioning

confidence: 99%

Comparison of NIR chemical imaging with conventional NIR, Raman and ATR-IR spectroscopy for quantification of furosemide crystal polymorphs in ternary powder mixtures

Schönbichler

Bittner

Weiss³

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

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Section: Discussionmentioning

confidence: 99%

Comparison of NIR chemical imaging with conventional NIR, Raman and ATR-IR spectroscopy for quantification of furosemide crystal polymorphs in ternary powder mixtures

Schönbichler

Bittner

Weiss³

et al. 2013

European Journal of Pharmaceutics and Biopharmaceutics

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“…This may be due to the fact that the spray drying process led to the re-crystallization of some PXM molecules in the Form II (lower melting point) polymorph of PXM [63]. This observation can be confirmed in the SEM image of spray-dried PXM (Supplementary materials figure 1) as needle-shaped PXM particles that are characteristic of Form II PXM were also observed [68]. GLU appears as a single endothermic peak on the DSC trace (Supplementary materials figure 2) with a melting point at 210.27 ˚C.…”

Section: Resultsmentioning

confidence: 62%

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Adebisi

Kaialy

Hussain

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2016.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 4. GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations. Technique could be used to determine appropriate formulations that improve handling AbstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging was also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM.XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 µm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5 nC/g for untreated material and -7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1 -0.3 3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

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“…This indicates that the ratio of piroxicam to poloxamer polymer influences the crystal size. In addition, it has been emphasized that increased wettability of piroxicam results in increased dissolution . Hence, in our research the 0.05% w/w piroxicam poloxamer‐based formulation with needle‐shaped crystals showed higher solubility and permeation than the non‐poloxamer‐based formulation with cube‐shaped crystals.…”

Section: Discussionmentioning

confidence: 57%

Formulation and evaluation of sublingual delivery of piroxicam using thermosensitive polymer with an inverted Franz diffusion cell

Sivaraman

Banga

2015

Journal of Pharmacy and Pharmacology

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Quantitative analysis of piroxicam polymorphs pharmaceutical mixtures by hyperspectral imaging and chemometrics

Cited by 73 publications

References 24 publications

Comparison of NIR chemical imaging with conventional NIR, Raman and ATR-IR spectroscopy for quantification of furosemide crystal polymorphs in ternary powder mixtures

Comparison of NIR chemical imaging with conventional NIR, Raman and ATR-IR spectroscopy for quantification of furosemide crystal polymorphs in ternary powder mixtures

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Formulation and evaluation of sublingual delivery of piroxicam using thermosensitive polymer with an inverted Franz diffusion cell

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