Quantitative analysis of oxytocin in pharmaceutical preparations by high-performance liquid chromatography

Capillary electrophoresis separation of the desamino degradation products of oxytocin

“…In 1981, Nachtmann et al compiled the then current knowledge of the physical, chemical, and pharmaceutical characteristics of OT, noting the importance of formulation pH on the rate of degradation . In the following years, several methods were published in which LC‐UV was used to determine OT quality in pharmaceutical dosage forms , including the US and EU pharmacopoeias . In these stability‐indicating methods, OT was resolved from its pH‐, heat‐, light‐, and oxidative‐stress degradation products.…”

Development and validation of a stability-indicating analytical method for the quantitation of oxytocin in pharmaceutical dosage forms

“…The main disadvantage for the use of the ion pairing agents is the long time that is needed to equilibrate the column and the remove the ion pair agent from the column [7]. Ohta et al [8] and Dudkiewicz-Wilczyńska et al [9] lished simple isocratic methods for the quantitating OT in dosage forms. Maxl and Siehr published a gradient method for the quality control of OT [10].…”