Quantitative Analysis of Optical Coherence Tomography Angiography Features in Patients with Nonocular Behcet’s Disease

Göker, Yasin Şakir; Yılmaz, Sedat; Kızıltoprak, Hasan; Tekin, Kemal; Demir, Gökhan

doi:10.1080/02713683.2018.1530361

Cited by 21 publications

(17 citation statements)

References 22 publications

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“…13,17 For the comparison of FAZ area between NOBD patients and HVs, other studies have reported inconsistent results. Similar to our results, Goker et al 19 found FAZ enlargement, whereas three other studies 8,18,20 did not find a significant difference in FAZ area between NOBD patients and HVs. These inconsistent reports on FAZ area differences between NOBD eyes and healthy eyes could be explained by the high between-subject variability of FAZ area measurements in healthy eyes.…”

Section: Discussionsupporting

confidence: 91%

“…8,[18][19][20] VD was reduced in NOBD patients compared to healthy control subjects in three out of the four studies, 8,19,20 and FAZ area was larger in the NOBD than in healthy controls in only one of the four studies. 19 Given the limited number of studies and their inconsistent results mainly due to small sample sizes, further exploration of preclinical retinal microvascular changes in NOBD patients compared to BU patients in a large group and a comparison to healthy volunteers (HVs) is warranted. Also, a quantitative measure for FAZ irregularity as a marker of ocular involvement in BD has not been explored.…”

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confidence: 77%

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Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography

Smid

Vermeer

Missotten

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To compare quantitative optical coherence tomography angiography (OCT-A) measurements of the parafoveal microvasculature in retinal capillary plexuses among Behҫet uveitis (BU) patients, non-ocular Behҫet's disease (NOBD) patients, and healthy volunteers (HVs). METHODS. Sixty-eight subjects were enrolled in this prospective observational crosssectional study. OCT-A imaging was performed using the Heidelberg Engineering Spectralis OCT. A custom algorithm was developed to calculate the vessel density (VD) in three retinal vascular layers: deep capillary plexus, intermediate capillary plexus, and superficial vascular plexus. The foveal avascular zone (FAZ) and acircularity index were calculated for the whole retinal vascular complex. RESULTS. We analyzed one eye from 21 BU patients (age, 51 ± 10 years), 23 NOBD patients (age, 48 ± 14 years), and 22 HVs (age, 44 ± 13 years). One-way multivariate analysis of covariance showed a statistically significant difference in VD among the three groups when combining the layers after controlling for scan quality (P < 0.001). The VD was lowest in the BU group and highest in the HV group in all layers. The FAZ area was also statistically significant different among the groups (P < 0.005), with the largest FAZ areas in BU patients and smallest FAZ areas in the HV group. However, no statistically significant difference was found for the acircularity index. CONCLUSIONS. The parafoveal microvasculature is affected not only in BU patients but also in NOBD patients. Most deviations in the retinal microcirculation in Behҫet patients were found in the deeper layers of the retina by using the quantitative VD measurement.

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Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 77%

Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography

Smid

Vermeer

Missotten

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…OCTA allows clinicians to quantitatively measure different parameters including FAZ area, AI, FD-300 and vessel densities of macular capillary plexuses in various retinal disorders [ 5 - 8 ]. These parameters offer information about the prognosis of retinal diseases and can also be used in the follow-up process.…”

Section: Discussionmentioning

confidence: 99%

“…It is a safe and advanced resolution imaging modality that allows the assessment of retinal microcirculation without the need of fluorescein usage [ 4 ]. OCTA also allows the evaluation of foveal avascular zone (FAZ) features, capillary nonperfusion areas, vessel density in both superficial (SCP) and deep capillary plexuses (DCP) quantitatively in different retinal disorders [ 5 - 8 ]. While evaluating vessel density in foveal region, different algorithms of OCTA including density evaluation software and/ or FAZ evaluation software could be used [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Direct and crossover effects of Phenylephrine and Cyclopentolate on foveal avascular zone and vessel density of macular capillary plexuses: an optical coherence tomography angiography study

Göker¹,

Kızıltoprak²,

Tekin³

et al. 2020

rjo

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Purpose: To determine the influence of phenylephrine and cyclopentolate on foveal avascular zone (FAZ) and vessel density of macular capillary plexus measurements via optical coherence tomography angiography (OCTA). Materials and Methods: The participants were separated into 2 groups according to the administration of drops. One drop of phenylephrine 2.5% was administered on one eye of each subject in the phenylephrine group (n=30) and one drop of cyclopentolate 1% in the cyclopentolate group (n=30). FAZ parameters and vessel density values of both superficial (SCP) and deep capillary plexuses (DCP) were calculated via OCTA priorly and at 45 min following the drop administration in both eyes. Vessel density, acircularity index of FAZ, FAZ area, perimeter of FAZ and foveal density-300 were evaluated via OCTA. Results: The vessel density values of fovea in SCP and DCP was 18.51±7.14% and 36.05±8.76% and significantly decreased to 16.16±6.26% and 33.29±9.47% respectively after drop instillation in dilated eyes in phenylephrine group (p=0.041 and p=0.032). Likewise, the vessel density values in SCP and DCP were 21.56±7.74% and 39.27±8.76% and significantly decreased to 18.89±7.32% and 35.36±5.75% respectively, after drop instillation in dilated eyes in cyclopentolate group (p=0.035 and p=0.028). However, there was no significant difference between before and after instillation of drops in terms of foveal density-300 value via FAZ assessment tool in both dilated and nondilated contralateral eyes in both groups (p>0.05 for all). Conclusions: Mydriasis with phenylephrine and/ or cyclopentolate did not affect the foveal density-300 values while analyzing the perfusion of macula. Vessel density in foveal region should be evaluated via FAZ evaluation software of the OCTA.

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“…As a speci c uveitis entity, mainly involving retinal vessels, Behcet's disease was the most common in which OCTA features were evaluated in a number of reports [7,[16][17][18][19][20][21]. In their report, Khairallah and coworkers found that the microvascular changes were more prominent in the DCP than the SCP.…”

Section: Discussionmentioning

confidence: 99%

Optical Coherence Tomography Angiography Findings in Non-Infectious Posterior Uveitis: A Controlled Study

Esen

Isik-Ericek

Demircan

2021

Preprint

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Background: To analyze the microvascular parameters using optical coherence tomography angiography (OCTA) in non-infectious posterior uveitis (PU) patients. Methods: In this cross-sectional study, OCTA images of patients with non-infectious PU were evaluated. The vessel densities (VD) in the superficial and deep capillary plexuses (SCP & DCP), foveal avascular zone (FAZ) area were measured and compared to healthy controls. Results: The study cohort comprised 64 patients with age and gender-matched groups. The VD in the SCP was 43.9±3.9% in the whole image; 18.4±4.8% in the fovea, 43.9±4.6% in the parafoveal area, and 43.4±9.7% in the perifoveal zone, in eyes with uveitis. These were respectively 48.8±2.9%, 22.9±6.9%, 50.9±3.0%, and 49.2±3.1% in the control group (p=0.0001, 0.043, 0.0001, 0.01, respectively). The changes in the DCP in eyes with uveitis were not significant. In the uveitis group, the FAZ was significantly enlarged compared to controls (0.37±0.1 microns vs. 0.24±0.2 microns, p=0.046). Conclusion: OCTA depicted significant changes including decreased VD in the SCP and enlarged FAZ in non-infectious PU.

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Quantitative Analysis of Optical Coherence Tomography Angiography Features in Patients with Nonocular Behcet’s Disease

Cited by 21 publications

References 22 publications

Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography

Parafoveal Microvascular Alterations in Ocular and Non-Ocular Behҫet's Disease Evaluated With Optical Coherence Tomography Angiography

Direct and crossover effects of Phenylephrine and Cyclopentolate on foveal avascular zone and vessel density of macular capillary plexuses: an optical coherence tomography angiography study

Optical Coherence Tomography Angiography Findings in Non-Infectious Posterior Uveitis: A Controlled Study

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