Quantitative Analysis of Microvasculature in Macular and Peripapillary Regions in Early Primary Open-Angle Glaucoma

Peripapillary Vessel Density in Eyes with Rhegmatogenous Retinal Detachment after Pars Plana Vitrectomy

“…ese pathological alterations may lead to persistent hypoperfusion in the ONH several months after the vitrectomy, the loss and permanent functional impairment of retinal ganglion cells and photoreceptors, and thus compromising visual acuity. ese findings were similar to those reported in previous studies of patients with glaucoma that lower peripapillary VD was detected in early glaucoma [21] and was associated with the progression of glaucoma [22]. Since pars plana vitrectomy has been reported to increase the risk of open-angle glaucoma [23], it is of interest to investigate whether the decrease of peripapillary VD after vitrectomy in RRD patients is associated with the progression of glaucoma in long-term follow-up.…”

Optical Quality Assessed by Optical Quality Analysis System in Chinese Primary Open-Angle Glaucoma Patients and Its Correlations with Psychological Disturbances and Vision-Related Quality of Life

“…In recent years, the Optical Quality Analysis System (OQAS), a new instrument based on recording images from a point source object after reflection on the retina and a double pass through the ocular media, was developed and demonstrated to be a useful tool for comprehensively evaluating the objective optical quality of the eye [6], including cataract, refractive surgery, dry eye, macular diseases, and ocular hypertension [7-11]. The characteristic glaucoma damages, such as retinal nerve fiber layer (RNFL) loss, ganglion cell complex decrement, and microvasculature changes within the macular could be detected in early glaucoma patients [12]. The regional distribution of retinal ganglion cell loss was reported to be associated with vision-related QoL [13], and the contribution of the inner retina to the optical aberrations has also been confirmed by use of the double-pass method [14].…”

OCT Angiography for the Diagnosis of Glaucoma

“…Most of these studies found similar (nonsignificant difference) discriminatory ability (i.e., AUC) between peripapillary OCTA and OCT RNFL thickness. 21e24, 27,32,35,41,47,49,53 For example, Geyman et al 24 also found comparable effectiveness of OCTA-measured peripapillary vessel density and peripapillary RNFL parameters in distinguishing mild glaucoma eyes from control eyes (AUC global, 0.907 vs. 0.934; AUC superior, 0.951 vs. 0.928; AUC inferior, 0.893 vs. 0.896). Similarly, for distinguishing mild to moderate glaucoma eyes from healthy eyes, Rao et al found similar AUCs between peripapillary vessel density (range, 0.48e0.88) and RNFL thickness (range, 0.51e0.90) for the 6 sectors and overall average (P > 0.05 for all).…”

“…Several studies have found moderate to strong correlations or associations between OCTA vessel density and VF defects (Table 1). 21e26, 30,33,36,37,41,43,45,46,49 Sakaguchi et al 36 examined the correlation between VF sensitivity and vessel density or RNFL thickness in the 6 sectors around the optic disc and found that peripapillary vessel density showed the highest correlation with VF sensitivities in the corresponding sector for all 6 sectors (squared semipartial correlation: sr 2 ¼ 0.17e0.39), whereas the sector RNFL thickness showed the highest correlation only with VF sensitivity in the corresponding sector for the temporal, inferotemporal, and superotemporal sectors (sr 2 ¼ 0.02e0.34). Yarmohammadi et al 43 also found that in glaucoma patients with a VF defect in only 1 hemifield, circumpapillary vessel density showed as strong a correlation with VF mean sensitivity in each hemifield (affected hemifield: r ¼ 0.707; intact hemifield: r ¼ 0.450) as RNFL (affected hemifield: r ¼ 0.496; intact hemifield: r ¼ 0.340) and GCC (affected hemifield: r ¼ 0.482; intact hemifield: r ¼ 0.290) thickness measurements.…”

“…Many studies found moderate correlation between the peripapillary OCTA parameters and structural OCT parameters, both overall 21,24,31,33,36,37,47,49,51,52 and in sectors, 30,36,47,52 in glaucomatous eyes (Table 1). Lee et al 29 found a very strong correlation between decreased vessel density and RNFL defects on red-free fundus photographs with regard to both location (r ¼ 0.997; P < 0.001) and extent (r ¼ 0.988; P < 0.001).…”