Quantitative analysis of heavy metals in medicinal plants collected from environmentally diverse locations in India for use in a novel phytopharmaceutical product

Sadhu, Ananya; Upadhyay, Prabhat; Singh, Praveen; Agrawal, Aruna; Ilango, K.; Karmakar, Dipankar; Singh, G.P.I.; Dubey, Govind Prasad

doi:10.1007/s10661-015-4764-3

Cited by 20 publications

(9 citation statements)

References 40 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The formulations were found to have low levels of lead (Table 2) which were below the WHO recommended limit of 10 mg/kg while arsenic and mercury were completely absent in all the formulations (WHO, 2007). Trace elements such as chromium, iron, cobalt, zinc and copper are essential in very little quantities for enzyme function, synthesis of vitamins and haemoglobin formation (Sadhu et al, 2015). The formulations were found to contain reasonable amounts of iron and zinc, moderate amounts of selenium and calcium while manganese was absent ( Table 3).…”

Section: S/n Bacterial Contaminant Cov-pla1 Cov-pla2 Cov-pla3 Plaboosmentioning

confidence: 99%

Evaluation of the elemental, nutritional and antioxidant properties of Cov-Pla herbal preparations

Ajima¹,

Kolawole²,

Falang³

et al. 2020

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

Section: S/n Bacterial Contaminant Cov-pla1 Cov-pla2 Cov-pla3 Plaboosmentioning

confidence: 99%

Evaluation of the elemental, nutritional and antioxidant properties of Cov-Pla herbal preparations

Ajima¹,

Kolawole²,

Falang³

et al. 2020

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

“…The smaller the quantities of non-essential heavy metals in traditional nutraceutical products, the lower will be the risk to the consumers health Small quantities of non-essential heavy metals in traditional nutraceutical products as their absence eliminates the risk of noxious effects on health [80]. Consequently, it is necessary to implement a qualitative assessment of wild resources consumed directly or used in ethnomedicine, before using or processing them, by determining the heavy metal content [81].…”

Section: Safety In Herbal Medicinementioning

confidence: 99%

Consuming Blackberry as a Traditional Nutraceutical Resource from an Area with High Anthropogenic Impact

Vlad

Goji²,

Dinulică

et al. 2019

Forests

View full text Add to dashboard Cite

The most serious quality issue of natural resources for human consumption or medicinal purposes is the contamination with pollutants harmful to consumers. Common blackberry (Rubus fruticosus L.) is a sought-after nutraceutical and an important component in herbal medicine in many places around the globe. The present study aims to analyze the level of heavy metal bioaccumulation in blackberry organs, as well as its spatial distribution in two consecutive years immediately after the interruption of the extended activity of the industrial source of pollution. The research was conducted in one of the most polluted areas in Romania and Eastern Europe, within a 26 km radius of the source of pollution. The Pb, Cd, Cu, and Zn concentrations in the leaves, flowers, and unwashed blackberry fruits were analyzed spectrophotometrically through flame atomic absorption spectroscopy (FAAS). The results show that blackberry is an important bioaccumulator of these heavy metals—71% of the Pb concentration values and 100% of the Cd concentration values exceeded the World Health Organization thresholds by up to 29 and 15 times, respectively. Also, the leaves are the largest reservoirs of Pb and Zn (the median values: 51.4 mg/kg dry weight and 105.2 mg/kg d.w., respectively), and the flowers contained the largest quantities of Cd and Cu (2.54 mg/kg d.w. and 11.3 mg/kg d.w., respectively). The Pb concentrations decreased by a power function in relation to the distance from the source of pollution. The implications of these results on the safety of the use of blackberry are discussed. The urgent necessity for food education of the local population which consumes contaminated nutraceutical products is emphasized.

show abstract

“…However, the excess amount of metals is hazardous for human health, for example, Hg and As caused nervous system and cardiac damage. [10] On the basis of permissible data defined by the WHO and Ayush (India), we found the amount in relative irradiance leaves and stem [ Table 6] accordingly Hg (0.93 ± 0.04 ppm and 0.82 ± 0.04 ppm), As (0.93 ± 0.04 ppm and 0.94 ± 0.03 ppm), Co (0.060 ± 0.003 ppm and 0.002 ± 0.00 ppm), Cd (0.044 ± 0.005 ppm and 0.001 ± 0.00 ppm), Pb (0.526 ± 0.01 ppm and 0.633 ± 0.01 ppm), and Zn (1.93 ± 0.03 ppm and 0.377 ± 0.02 ppm). The result also revealed that leaf and stem part of plant R. indica can be used as for human health-care product or in the manufacturing of the herbal formulation.…”

Section: Preliminary Phytochemical Analysismentioning

confidence: 99%

Untitled

2018

IJGP

View full text Add to dashboard Cite

Background: Recent scenario and global trends are moving toward the medicinal plant used as health-care product for the treatment of different disease or disorder, but the critical and essential issue to be considered in assuring the therapeutic efficacy and safety. Thus standardization of plant parts need to standardized according to the standard guideline for global acceptance of the product. Reinwardtia indica belongs to Linaceae family used as folk medicine in Asia in the treatment and management of boils, carbuncle, and as an antimicrobial agent in wound healing traditionally. Objective: The present study aimed at physicochemical standardization of R. indica leaves and stem part of the plant. Materials and Methods: In our investigation, leaves and stem part of R. indica were standardized based on microscopy, powder microscopy, physicochemical evaluations, extractive yields, and heavy metal analysis as per the International Regulatory Norms. Results: The results revealed that the pharmacognostic parameters have shown the leaves and stem part of the R. indica plant found within the standard limit as per regulatory norms. Conclusion: The data found after standardization can be adopted as a standard of the plant R. indica, and it can be used in the formulation of the health care product after pre-clinical and clinical investigations.

show abstract

Quantitative analysis of heavy metals in medicinal plants collected from environmentally diverse locations in India for use in a novel phytopharmaceutical product

Cited by 20 publications

References 40 publications

Evaluation of the elemental, nutritional and antioxidant properties of Cov-Pla herbal preparations

Evaluation of the elemental, nutritional and antioxidant properties of Cov-Pla herbal preparations

Consuming Blackberry as a Traditional Nutraceutical Resource from an Area with High Anthropogenic Impact

Untitled

Contact Info

Product

Resources

About