Quantitative analysis of gallstones using laser-induced breakdown spectroscopy

Singh, Vivek K.; Singh, Vinita; Awadhesh, K.; Thakur, Surya N.; Pradeep, Konda Gokuldoss; Singh, Jagdish P.

doi:10.1364/ao.47.000g38

Cited by 67 publications

(39 citation statements)

References 40 publications

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“…The relative intensities of the spectral line of Mg I at 280.2 nm were recorded by focusing the laser beam at five equidistant points across the gallstone to evaluate the variation of the Mg concentration. Figure 3 illustrates results for non-granular gallstones in agreement with reported data [8,9], and Figure 3 shows the measured variations for typical 2-mm-3-mm granules investigated in this work. A gallstone continues to grow for Mg concentrations with a decreasing trend starting from the center or nucleation point.…”

Section: Resultssupporting

confidence: 87%

Gallstone Magnesium Distributions from Optical Emission Spectroscopy

Pathak¹,

Nilesh²,

Kumar³

et al. 2018

Atoms

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This work reports measurements of calcified gallstone elemental compositions using laser-induced optical emission spectroscopy. The experimental results support the importance of the magnesium concentration in gallstone growth. Granular stones reveal an increased magnesium concentration at the periphery of the granules, suggesting the inhibition of further growth. Non-granular gallstones reveal lower overall magnesium concentrations, but with higher values near the center.

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Section: Resultssupporting

confidence: 87%

Gallstone Magnesium Distributions from Optical Emission Spectroscopy

Pathak¹,

Nilesh²,

Kumar³

et al. 2018

Atoms

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“…Recently, laser induced breakdown spectroscopy (LIBS) has emerged as a valuable tool for in situ and in vivo analysis of any type of materials including biomaterials [24][25][26] . It does not require any sample preparation; it is a very sensitive, reliable, and quick analytical technique as well as having point detection capability [27][28][29] .…”

Section: Introductionmentioning

confidence: 99%

Detection of Biogenic Silica in Leaf Blade, Leaf Sheath, and Stem of Bermuda Grass (Cynodon dactylon) Using LIBS and Phytolith Analysis

Chauhan

Tripathi

et al. 2011

Food Biophysics

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Laser induced breakdown spectroscopy (LIBS) has been used to perform in situ analysis of major and minor elements present in the different parts of the Bermuda grass (Cynodon dactylon). In situ, point detection/analysis of the elements in plants without any sample preparation has been demonstrated. LIBS spectra of the different parts (leaf blade, leaf sheath and stem) of fresh C. dactylon plant have been recorded to study the pattern of silica deposition in its different parts. Atomic lines of Si, Mg, Ca, C, Al, Zn, N, Sr, etc. have been observed in the LIBS spectra of the C. dactylon. A close observation of LIBS spectra of the different parts of the plants shows that silica concentration is greater in leaf blades than leaf sheaths and stems. The results obtained with LIBS analysis are also compared with the number density of phytoliths deposited in different parts of C. dactylon. It is observed that the highest silicified cell frequency is present in leaf blades followed by leaf sheaths and stems which is in close agreement with LIBS analysis.

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“…This study demonstrates the use of laserinduced breakdown spectroscopy (LIBS) [15], a spectroscopic technique to investigate the sources of variability in coating uniformity in tablets and which attempts to establish statistical significance, or lack thereof, of the possible causes. The LIBS technique finds application in a wide variety of areas such as the study of soil composition [16], polymers [17], minerals [18], metallic compounds [19,20], cosmetics [21], gaseous mixtures [22], construction materials [23], hazardous material detection [24], and traditional fuels such as coal [25], fuel cells [26], and biological tissues [27,28]. The pharmaceutical industry is beginning to consider this technique for in-line monitoring and product analysis applications.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Pharmaceutical Tablet Coating Uniformity by Laser-Induced Breakdown Spectroscopy (LIBS)

et al. 2011

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A laser-induced breakdown spectroscopy-based analytical methodology is developed to study tablet coating variability in pharmaceutical tablets. The method quantifies the amount of coating on a tablet by assigning an average coating thickness score to it. When tested using samples with different amounts of coating, the coating thickness scores showed direct correlation to the weight gain of the tablet, hence validating the analytical method. The relative significance of the processing parameters and the components of variability were computed using statistical techniques. The sampling frequency of laser shots was found to have no significant effect. The effect of the position of the laser pulse on the tablet surface was found to be significant; however, it was determined that this effect was due to the tablet curvature, which resulted in the laser optical path to intersect the coating diagonally. The variability between batches (lots) manufactured under the same processing conditions was not significant. The largest avoidable source of variability was the tablet-to-tablet component, possibly indicating the inadequate mixing performance of the coating device.

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Quantitative analysis of gallstones using laser-induced breakdown spectroscopy

Cited by 67 publications

References 40 publications

Gallstone Magnesium Distributions from Optical Emission Spectroscopy

Gallstone Magnesium Distributions from Optical Emission Spectroscopy

Detection of Biogenic Silica in Leaf Blade, Leaf Sheath, and Stem of Bermuda Grass (Cynodon dactylon) Using LIBS and Phytolith Analysis

Analysis of Pharmaceutical Tablet Coating Uniformity by Laser-Induced Breakdown Spectroscopy (LIBS)

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