Quantitative Analysis of D-(+)-Glucose in Fruit Juices Using Diffusion Ordered-1H Nuclear Magnetic Resonance Spectroscopy

Cao, Ruge; Komura, Fusae; Nonaka, Airi; Kato, Takeshi; Fukumashi, Junji; Matsui, Toshiro

doi:10.2116/analsci.30.383

Cited by 21 publications

(14 citation statements)

References 20 publications

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“…approximately 0.4 mol L −1 , and both methods showed rather similar value, which is in the range reported in the literature, i.e. from 0.25 to 0.70 mol L −1 depending on variety and growth conditions 41, 42. In general, grapes have ca.…”

Section: Resultssupporting

confidence: 83%

Application of Polyfolates in the Development of Electrochemical Glucose Biosensors

et al. 2014

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Folic acid was polymerised electrochemically at a glassy carbon electrode surface from 0.1 mol L−1 phosphate buffer saline solution, pH 5.0, containing 0.1 mmol L−1 monomer. The obtained thin film was porous with a pore size of 50–60 nm. Since its electrochemical stability was rather short, the polyfolate film was covered with a graphene‐chitosan composite layer which increased its stability significantly. The best strategy to immobilise the enzyme was crosslinking with glutaraldehyde. The lifetime of this glucose biosensor in use was at least 12 days, on‐shelf life time was at least 30 days. The linear range was up to 1 mmol L−1 and the LOD was 0.6 µmol L−1. The first polyfolate‐based biosensor was applied to analysis of natural samples.

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Section: Resultssupporting

confidence: 83%

Application of Polyfolates in the Development of Electrochemical Glucose Biosensors

et al. 2014

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“…Quantitative diffusion ordered spectroscopy NMR (q-DOSY) relies on the quantitative 1 H NMR that requires of using an internal standard [ 52 , 53 ] and permits reliable quantification when using stimulated-echo DOSY sequences. Q-DOSY presents problems with complex mixtures that could have proton overlapping [ 54 ] and thus different decays, hence making data fitting difficult [ 55 ].…”

Section: Resultsmentioning

confidence: 99%

Production of Aromatic Compounds by Catalytic Depolymerization of Technical and Downstream Biorefinery Lignins

et al. 2020

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Lignocellulosic materials are promising alternatives to non-renewable fossil sources when producing aromatic compounds. Lignins from Populus salicaceae. Pinus radiata and Pinus pinaster from industrial wastes and biorefinery effluents were isolated and characterized. Lignin was depolymerized using homogenous (NaOH) and heterogeneous (Ni-, Cu- or Ni-Cu-hydrotalcites) base catalysis and catalytic hydrogenolysis using Ru/C. When homogeneous base catalyzed depolymerization (BCD) and Ru/C hydrogenolysis were combined on poplar lignin, the aromatics amount was ca. 11 wt.%. Monomer distributions changed depending on the feedstock and the reaction conditions. Aqueous NaOH produced cleavage of the alkyl side chain that was preserved when using modified hydrotalcite catalysts or Ru/C-catalyzed hydrogenolysis in ethanol. Depolymerization using hydrotalcite catalysts in ethanol produced monomers bearing carbonyl groups on the alkyl side chain. The analysis of the reaction mixtures was done by size exclusion chromatography (SEC) and diffusion ordered nuclear magnetic resonance spectroscopy (DOSY NMR). 31P NMR and heteronuclear single quantum coherence spectroscopy (HSQC) were also used in this study. The content in poly-(hydroxy)-aromatic ethers in the reaction mixtures decreased upon thermal treatments in ethanol. It was concluded that thermo-solvolysis is key in lignin depolymerization, and that the synergistic effect of Ni and Cu provided monomers with oxidized alkyl side chains.

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“…Diffusion-ordered (DOSY)-NMR measurements using spin-echo method [ 27 ] were performed at 25°C under the following conditions: scan, 128; 90° pulse-width, 9.9 μs; relaxation delay, 20 s; array type, logarithmic; range of pulse field gradient, 0.05–0.3 T/m; point, 8. The diffusion coefficient ( D , m 2 /s) value was calculated according to previous reports [ 19 , 28 ] The D value of the sample was normalized to that of DSS- d 6 (ca. 5 × 10 −10 m 2 /s) as IS to avoid the change of D value by solvent viscosity and temperature [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Evaluating the Reduced Hydrophobic Taste Sensor Response of Dipeptides by Theasinensin A by Using NMR and Quantum Mechanical Analyses

Guo

Hirasaki

Miyata³

et al. 2016

PLoS ONE

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The current study demonstrated that theasinensin A (TSA) had a potential to form the complex with hydrophobic Trp-containing dipeptides, and to reduce their membrane potential by artificial-lipid membrane taste sensor. At a 1:3 molar ratio of the 6 Trp-containing dipeptides together with TSA, we observed a significant chemical shift of the protons of the dipeptides (Δδ) to a high magnetic field, when analyzed using 1H-nuclear-magnetic resonance (NMR) spectroscopy. The Δδ values were correlated with the hydrophobicity (log P) of the dipeptides and significant correlations were obtained (P = 0.022, R2 = 0.77); e.g., Trp-Leu with the highest log P value of 1.623 among the tested dipeptides showed the highest Δδ value of 0.105 ppm for the H7 proton of Trp-Leu, while less chemical shifts were observed in theasinensin B and epigallocatechin-3-O-gallate. Diffusion-ordered NMR spectroscopy revealed that the diffusion coefficient of 3 mM of Trp-Leu (7.6 × 10−11 m2/s) at a pulse field gradient in the range 0.05–0.3 T/m decreased in the presence of 3 mM TSA (6.6 × 10−11 m2/s), suggesting that Trp-Leu forms a complex with TSA. Quantum mechanical calculations and rotating frame nuclear Overhauser effect-NMR spectroscopy provided configuration information on the geometry of the complex that Trp-Leu formed with TSA (1:1 complex) with a ΔG energy of –8.7 kJ/mol. A sensor analysis using artificial-lipid membranes demonstrated that the changes in membrane potential of 1 mM Trp-Leu (21.8 ± 1.3 mV) and Leu-Trp (5.3 ± 0.9 mV) were significantly (P < 0.001) reduced by 1 mM TSA (Trp-Leu, 13.1 ± 2.4 mV; Leu-Trp, 3.5 ± 0.5 mV; TSA alone, 0.2 ± 0.01 mV), indicating the effective suppression of hydrophobicity of dipeptides by TSA-formed complex.

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Quantitative Analysis of D-(+)-Glucose in Fruit Juices Using Diffusion Ordered-1H Nuclear Magnetic Resonance Spectroscopy

Abstract: This study works on D-(+)-glucose quantitative analysis using diffusion ordered-quantitative 1 H nuclear magnetic resonance spectroscopy (DOSY-qNMR), by which an analyte could be distinguished from interferences based upon a characteristic diffusion coefficient (

Cited by 21 publications

References 20 publications

Application of Polyfolates in the Development of Electrochemical Glucose Biosensors

Application of Polyfolates in the Development of Electrochemical Glucose Biosensors

Production of Aromatic Compounds by Catalytic Depolymerization of Technical and Downstream Biorefinery Lignins

Evaluating the Reduced Hydrophobic Taste Sensor Response of Dipeptides by Theasinensin A by Using NMR and Quantum Mechanical Analyses

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