Application of Polyfolates in the Development of Electrochemical Glucose Biosensors

Venckus, Tautvydas; Celiešiūtė, Raimonda; Radzevič, Aneta; Rakickas, Tomas; Vaitekonis, Šarūnas; Ruželė, Živilė; Pauliukaitė, Rasa

doi:10.1002/elan.201400293

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…Since it was known from our previous works that poly(folic acid) (PFA) and polyriboflavin (PRf) act as mediators in electrochemical sensing [24][25][26], they were chosen to modify the electrode with a sensitive layer. Figure 2a, b represent the electropolymerisation of FA and Rf, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Figure 2a, b represent the electropolymerisation of FA and Rf, respectively. It was found in the previous works that PFA assures better sensitivity to an analyte but PRf guarantees better stability of a biosensor [24,25]. Therefore, a co-polymer PFA-PRf was synthesised on the GCE surface (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Although a number of sensing approaches have been published, the majority of them require expensive materials and complex construction. Polymers composed of vitamin B group compounds have been already successfully applied for sensing applications [24][25][26]. Owing to this, it is a novel approach to test these polymers for the determination of atrazine.…”

Section: Introductionmentioning

confidence: 99%

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A novel strategy to develop electrochemical atrazine sensor

Katinaitė¹,

Žutautas²,

Bytautaitė³

et al. 2022

chemija

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Determination of pesticides is important for human health. Sensors are one of the best solutions because they do not require a long sample preparation and can be used not only in a laboratory. Electrochemical sensors can be easily minimised and employed for the detection of pesticides in liquid samples such as ground or wastewater. Conducting polymers have a few roles in electrochemical sensors, therefore, they can be good candidates for sensor development. Electrochemically co-polymerised folic acid and riboflavin as well as folic acid and L-lysine were employed for the detection of atrazine using square wave voltammetry. The co-polymer composition was optimised and characterised electrochemically and spectroscopically. The optimal composition of polyfolic acid and poly-L-lysine co-polymer electrosynthesised from the monomer ratio 1:10 was the best in terms of stability and sensitivity to atrazine. The best method was the square wave voltammetry showing the best sensitivity to atrazine 198 ± 1 μA/μM cm2, and the limit of detection was 14.8 nM. However, the sensitivity in tap water was significantly lower but still suitable for atrazine detection by the spike method.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A novel strategy to develop electrochemical atrazine sensor

Katinaitė¹,

Žutautas²,

Bytautaitė³

et al. 2022

chemija

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“…This layer can be also composed of naturally-occurring compounds. Our recent works reports an application of several compounds from vitamin B group—riboflavin (B 2 ) and folic acid (B 9 )—for biosensing [ 57 , 65 , 66 , 67 , 68 ]. These vitamins should be polymerized because they are soluble in water and will leak from the electrode surface in their monomeric form [ 65 , 67 ].…”

Section: Principles Of Mss and Msamentioning

confidence: 99%

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

Pauliukaitė

Voitechovič

2020

Sensors

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The significant improvement of quality of life achieved over the last decades has stimulated the development of new approaches in medicine to take into account the personal needs of each patient. Precision medicine, providing healthcare customization, opens new horizons in the diagnosis, treatment and prevention of numerous diseases. As a consequence, there is a growing demand for novel analytical devices and methods capable of addressing the challenges of precision medicine. For example, various types of sensors or their arrays are highly suitable for simultaneous monitoring of multiple analytes in complex biological media in order to obtain more information about the health status of a patient or to follow the treatment process. Besides, the development of sustainable sensors based on natural chemicals allows reducing their environmental impact. This review is concerned with the application of such analytical platforms in various areas of medicine: analysis of body fluids, wearable sensors, drug manufacturing and screening. The importance and role of naturally-occurring compounds in the development of electrochemical multisensor systems and arrays are discussed.

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“…FA is also sensitive to a pH range between 6.0 and 10.0 [20]. Moreover, PFA was previously used to develop sensors for glucose [21], dopamine [22], and pH [23].…”

Section: Introductionmentioning

confidence: 99%

A Sensor for Electrochemical pH Monitoring Based on Laser-Induced Graphene Modified with Polyfolate

Žutautas,

Trusovas,

Sartanavičius

et al. 2023

Chemosensors

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A laser-induced graphene (LIG) modified with chitosan (Chit) and conducting polymer polyfolate (PFA) was used as a base to develop a flat and flexible pH sensor. LIGs were formed using two different irradiation wavelengths of 355 nm and 532 nm. Depending on the wavelengths, the obtained electrodes were named LIG355 and LIG532. Microscopic imaging revealed that the bare LIG electrode surface had rough structures after laser treatment giving hydrophilic properties, and that PFA forms fibre-like structures on Chit coated LIG. Electrochemical investigation with the redox probe demonstrated that diffusion is a limiting process at the bare and modified LIG electrodes. A capacitive behaviour was observed from electrochemical impedance spectra at bare electrodes, showing a rather rough interface at LIG355 but a microporous one at LIG532. The developed flat and flexible electrode was sensitive to pH in the region from 6.0 to 9.0. In the studied pH range, the sensitivity was 27.86 ± 0.81 for PFA/Chit/LIG355 and 30.32 ± 0.50 mV/pH for PFA/Chit/LIG532 with moderate stability for a period of more than two months.

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Application of Polyfolates in the Development of Electrochemical Glucose Biosensors

Cited by 6 publications

References 38 publications

A novel strategy to develop electrochemical atrazine sensor

A novel strategy to develop electrochemical atrazine sensor

Multisensor Systems and Arrays for Medical Applications Employing Naturally-Occurring Compounds and Materials

A Sensor for Electrochemical pH Monitoring Based on Laser-Induced Graphene Modified with Polyfolate

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