Quantitative analysis of coronary endothelial function with generator-produced 82Rb PET: comparison with 15O-labelled water PET

Abstract

Purpose Endothelial dysfunction is the earliest abnormality in the development of coronary atherosclerosis. Rb PET may be applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors.

Assessment of Coronary Vasoreactivity by Multidetector Computed Tomography - Feasibility Study With Rubidium-82 Cardiac Positron Emission Tomography -

“…Yoshinaga et al recently demonstrated that MBF measurement by 82 Rb PET/CT using the same 2-compartment model was comparable with MBF measurement by 15 O-water, which is the gold standard for the assessment of MBF. 38 This technique allows assessment of endothelium-dependent coronary vasomotion, which can be impaired by cardiovascular risk factor such as diabetes, 39,40 smoking, 41,42 hypercholesterolemia 43,44 or menopause. 45 Moreover, it provides information about epicardial coronary artery stenosis or diffuse microvascular disease, which may decrease the MFR and affect the response to CPT.…”

Myocardial Blood Flow Quantification Using Positron-Emission Tomography

“…Smokers showed reduced MBF response during the CPT using 82 Rb, which was similar to the MBF response observed using 15 Olabeled water as a standard measurement. 21 That study suggests that 82 Rb PET is applicable for risk assessments or evaluation of risk factor modification in subjects with coronary risk factors. This approach was confirmed by another group.…”

“…82 Rb is produced from a strontium-82 ( 82 Sr)/ 82 Rb generator and is widely used in centers without immediate access to a cyclotron. 20, 21 Recently introduced 18 F-labeled perfusion tracers have a relatively longer half-life (110 min), which means they could possibly be delivered from pharmaceutical companies to hospitals.…”

“…In addition, patients with CAD usually have hyperemic MBF of less than 3.0 ml · min -1 · g -1 , and retained tracers still preserve relatively good extraction within this range. 21 Interestingly, 18 F-labeled perfusion tracers have a high extraction fraction and are expected to produce accurate MBF measurements. 15,22 Originally, 11 C-acetate was used to estimate myocardial oxidative metabolism.…”

Physiological Assessment of Myocardial Perfusion Using Nuclear Cardiology Would Enhance Coronary Artery Disease Patient Care - Which Imaging Modality Is Best for Evaluation of Myocardial Ischemia? (SPECT-Side) -

“…Recently, some cardiovascular centers in Japan and Europe have begun 82 Rb studies. 38 Thus, PET MPI using 82 Rb could be widely available shortly.…”