Myocardial Blood Flow Quantification Using Positron-Emission Tomography

Integrated Myocardial Perfusion Imaging Diagnostics Improve Detection of Functionally Significant Coronary Artery Stenosis by 13 N-ammonia Positron Emission Tomography

“…It may be that stress MBF or CFR assessments by 13 NH 3 -PET are determined by both macro-and microvasculature, 42,43 which our subgroup analysis supports. In patients with known risk factors for microvascular disease (female sex, LVH, or advanced age) [44][45][46] or with high IMR, the diagnostic accuracy of stress MBF or CFR for low FFR is significantly reduced. As Johnson and Gould 43 suggested, the discordance among multiple physiological indices, such as FFR, CFR, or stress MBF, shows the importance of comprehensive physiological assessment to better understand the heterogeneous mechanism of ischemic heart disease in each patient.…”

Combined Supine and Prone Myocardial Perfusion Single-Photon Emission Computed Tomography With a Cadmium Zinc Telluride Camera for Detection of Coronary Artery Disease

“…14, 15 After 3 min of ATP infusion, 99 m Tc-tetrofosmin (n=175) or 99 m Tc-sestamibi (n=95) was injected at a dose ranging from 296 to 370 MBq and imaging was started 60 min later. Five-minute data acquisition was performed first in the supine position and immediately thereafter in the prone position using the CZT gamma camera.…”

Feasibility of Quantifying Myocardial Blood Flow with a Shorter Acquisition Time Using ¹⁵O-H₂O PET

“…The use of PET MBF data is also useful for detecting endothelial dysfunction even in preclinical disease (6)(7)(8)(9) and for assessing the risk of atherosclerosis (10,11). 15 O-labeled water ( 15 O-H2O), 13 N-ammonia and 82 rubidium are the PET tracers commonly used in the assessment of MBF (12)(13)(14). 15 O-H2O is known an ideal PET tracer for the quantification of MBF because of the high extraction fraction it provides (15).…”

“…15 O-labeled water ( 15 O-H2O), 13 N-ammonia and 82 rubidium are the PET tracers commonly used in the assessment of MBF (12)(13)(14). 15 O-H2O is known an ideal PET tracer for the quantification of MBF because of the high extraction fraction it provides (15). However, 15 O-H2O has limited image quality because it is an inert, freely diffusible tracer (16).…”

“…15 O-H2O is known an ideal PET tracer for the quantification of MBF because of the high extraction fraction it provides (15). However, 15 O-H2O has limited image quality because it is an inert, freely diffusible tracer (16).…”