Feasibility of Quantifying Myocardial Blood Flow with a Shorter Acquisition Time Using &lt;sup&gt;15&lt;/sup&gt;O-H&lt;sub&gt;2&lt;/sub&gt;O PET

Maruo, Ayaka; Manabe, Osamu; Yoshinaga, Keiichiro; Naya, Masanao; Tomiyama, Yoshiaki; Oyama‐Manabe, Noriko; Hirata, Kenji; Magota, Keiichi; Tsutsui, Hiroyuki; Katoh, Chietsugu; Tamaki, Nagara

doi:10.17996/anc.15002

Cited by 4 publications

(2 citation statements)

References 33 publications

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“… 58 The shorter half-life (2.04 minutes) enables consecutive rest/stress protocols, similar to the case with 82 Rb. 59 , 60 However, 15 O-H 2 O requires an on-site cyclotron for tracer production and also is suboptimal for visual assessment due to the low signal-to-noise ratios. These conditions lead to its use being limited in clinical settings.…”

Section: Radiotracers Categorized By Usementioning

confidence: 99%

Radiopharmaceutical tracers for cardiac imaging

Manabe

Kikuchi

Scholte

et al. 2018

Journal of Nuclear Cardiology

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Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Nuclear myocardial perfusion imaging with either single-photon emission computed tomography or positron emission tomography has been used extensively to perform diagnosis, monitor therapies, and predict cardiovascular events. Several radiopharmaceutical tracers have recently been developed to evaluate CVD by targeting myocardial perfusion, metabolism, innervation, and inflammation. This article reviews old and newer used in nuclear cardiac imaging.Electronic supplementary materialThe online version of this article (10.1007/s12350-017-1131-5) contains supplementary material, which is available to authorized users.

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Section: Radiotracers Categorized By Usementioning

confidence: 99%

Radiopharmaceutical tracers for cardiac imaging

Manabe

Kikuchi

Scholte

et al. 2018

Journal of Nuclear Cardiology

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“…Also, the measurement of MBF by PET is highly reproducible (26,27). Recently it was reported that even shorter acquisition time did not hamper the reproducibility of MBF measurement using 15 O water PET (28). However, MBF values can vary according to which tracers or methods are used (29,30).…”

Section: Ffr Vs Mbfmentioning

confidence: 99%

Flow-Based Functional Assessment of Coronary Artery Disease by Myocardial Perfusion Positron Emission Tomography in the Era of Fractional Flow Reserve

Cho

Kim

Bom

2016

Annals of Nuclear Cardiology

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Quantification of Coronary Flow Reserve by <sup>15</sup>O-Water PET with ATP Stress; from a Practical Application Perspective

Miyagawa

Miyauchi

Ishimura

et al. 2016

Annals of Nuclear Cardiology

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15O-water has been considered to be a near-perfect and the most ideal myocardial blood flow (MBF) tracer because it is freely diffusible, metabolically inert, and independent of the myocardial metabolic state, which results in the highest extraction fraction. Absolute coronary flow reserve (CFR) is the ratio of MBF during maximal hyperemia in a coronary artery to MBF in the same artery under resting conditions and can be quantified noninvasively by positron emission tomography (PET). A growing body of literature is accumulating to show that the prognostic value of absolute MBF or CFR, which is quantified by cardiac PET.

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Feasibility of Quantifying Myocardial Blood Flow with a Shorter Acquisition Time Using <sup>15</sup>O-H<sub>2</sub>O PET

Cited by 4 publications

References 33 publications

Radiopharmaceutical tracers for cardiac imaging

Radiopharmaceutical tracers for cardiac imaging

Flow-Based Functional Assessment of Coronary Artery Disease by Myocardial Perfusion Positron Emission Tomography in the Era of Fractional Flow Reserve

Quantification of Coronary Flow Reserve by <sup>15</sup>O-Water PET with ATP Stress; from a Practical Application Perspective

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