Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging in Invasive Breast Cancer: A Novel Technique to Obtain Histopathologic Information of Microvessel Density

Mori, Nobuhiro; Mugikura, Shunji; Takahashi, Satoshi; Ito, Koichi; Takasawa, Chiaki; Li, Li; Miyashita, Minoru; Kasajima, Atsuko; Mori, Yu; Ishida, Toru; Kodama, Tetsuya; Takase, Kei

doi:10.1016/j.ultrasmedbio.2016.11.009

Cited by 25 publications

(15 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Change in tumor size takes time (for example at least after two to three treatment cycles) [ 1 ]. Therefore, some functional methods [ 14 ], such as contrast-enhanced ultrasound [ 11 ], MRI [ 16 ] and fluorodeoxyglucose (FDG PET) [ 6 ], have been researched to assess NAC treatment response. However, contrast-enhanced ultrasound was invasive and still pending for approval of microbubble contrast agents for this indication.…”

Section: Discussionmentioning

confidence: 99%

Prediction of neoadjuvant chemotherapy response using diffuse optical spectroscopy in breast cancer

Zhu

et al. 2017

Clin Transl Oncol

View full text Add to dashboard Cite

PurposeNear-infrared diffuse optical spectroscopy (DOS) has been recently used to predict neoadjuvant chemotherapy response (NAC). In the present study, we explore the change in blood-oxygen content using DOS to predict NAC response against breast cancer.Materials and methodsA total of 20 patients were enrolled and underwent DOS scan with blood-oxygen detection before each treatment cycle. The first DOS scan was performed before NAC treatment (pretreatment), and subsequent scans were performed after each NAC treatment circle. Changes in blood content and oxygen content by DOS were evaluated and compared with tumor size, and their changes were analyzed in response versus nonresponse group.ResultsThirteen patients were classified into response and seven patients into nonresponse group. The tumor blood content value (−1.06 ± 0.43) and oxygen content value (0.48 ± 0.17) of DOS at pretreatment was significantly different from presurgery in response group (P < 0.05), but not in nonresponse group. In response group, the percentage change in blood content (median 91.19%) was significantly larger than tumor size (median 48.89%) (P = 0.0035), while in oxygen content (median 47.11%) is not (P = 0.2815). Comparing each cycle, the percentage change in blood content could distinguish responder from non-responder as early as after the first treatment cycle (19.1 versus 6.6%, P = 0.0265). Blood content percentage sensitivity was 76.9% and specificity was 85.7% (AUC 0.912), while oxygen content percentage sensitivity was 76.9% and specificity was 71.4% (AUC 0.797).ConclusionBoth blood and oxygen content measured by DOS could be used to discriminate responder to the treatment versus non-responder. Among the two, percentage change of blood content was more precise and earlier than that of oxygen content to predicted breast tumor response. The percentage change in blood content could distinguish responder from non-responder after the first treatment cycle.

show abstract

Section: Discussionmentioning

confidence: 99%

Prediction of neoadjuvant chemotherapy response using diffuse optical spectroscopy in breast cancer

Zhu

et al. 2017

Clin Transl Oncol

View full text Add to dashboard Cite

show abstract

“…In addition, MVD is one of the gold standards for the assessment of angiogenesis and vascular normalization. 27 Mori et al 33 reported that the parameters of CEUS, such as PI, was significantly correlated with MVD in breast cancer ( r =0.43). The correlation exhibited a significant difference ( P =0.0073).…”

Section: Discussionmentioning

confidence: 99%

Clinical evaluation of vascular normalization induced by recombinant human endostatin in nasopharyngeal carcinoma via dynamic contrast-enhanced ultrasonography

Yang¹,

Kang²,

Zhu³

et al. 2018

OTT

View full text Add to dashboard Cite

BackgroundThe present study confirmed the presence and exact range of “vascular normalization window” induced by recombinant human endostatin (RHES) in patients with nasopharyngeal carcinoma (NPC) by analyzing the variation of dynamic contrast-enhanced ultrasonography (DCE-US) quantitative parameters. Also, the clinical application of DCE-US in the evaluation of vascular normalization was assessed.Materials and methodsA total of 30 previously untreated patients with stage III–IVA NPC were enrolled in the present study and were randomly but equally divided into RHES (endostar [ES]) and normal saline (NS) groups. The patients in the ES group were administered RHES intravenously, while the patients in the NS group were administered normal saline daily for 5 days prior to intensity modulated radiotherapy coupled with concurrent chemotherapy. All patients underwent DCE-US on the day before the administration and on days 3 and 5 subsequently. The Audio Video Interleave of each DCE-US examination was analyzed quantitatively using the CHI-Q software. Several parameters were investigated, such as peak intensity (PI), time to peak (TTP), and mean transit time (MTT).ResultsThe PI, TTP, and MTT differed significantly at the three time points in the ES group (all P<0.001) but not in the NS group (all P>0.05). In the ES group, PI increased and subsequently decreased, whereas TTP, as well as MTT, lessened initially and then increased within the 5 days after administration of RHES. The maximum value of PI and the minimum value of TTP, as well as MTT, occurred on day 3 (all P<0.05). Furthermore, the values of PI, TTP, and MTT were similar prior to the administration of RHES in both groups (all P>0.05). However, the PI of the ES group was significantly higher (P<0.05), whereas the TTP and the MTT were significantly lower following administration of RHES (all P<0.05) compared with the corresponding parameters of the NS group.ConclusionDCE-US is a suitable method for the clinical evaluation of vascular normalization induced by antiangiogenic agents. The “vascular normalization window” induced by RHES occurs in patients with NPC, and the exact range is within about 5 days post-administration, which contributes towards optimizing the modality of RHES combined with radiotherapy and chemotherapy for NPC patients.

show abstract

“…Contrast-enhanced ultrasound (CEUS) is of interest because of its ability to glean macrovascular and microvascular information about organs and to aid our understanding of the complexity of angiogenesis in different types of tumors [9][10][11][12][13]. CEUS is a quantitative kinetic imaging modality that assesses intravascular blood flow in breast tumors even at the capillary level [14][15][16][17][18][19]. We hypothesized that changes in the pharmacokinetics of contrast material would reflect early neovascular changes in breast tumors during NAC and could be detected by CEUS, thereby allowing assessment of the early response to therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

Contrast-Enhanced Ultrasound for Early Prediction of Response of Breast Cancer to Neoadjuvant Chemotherapy

Lee

Kim

Kang

et al. 2019

Senologie - Zeitschrift für Mammadiagnostik und -therapie

View full text Add to dashboard Cite

Purpose To evaluate the time-intensity curve (TIC) parameters on contrast-enhanced ultrasound (CEUS) for early prediction of the response of breast cancer to neoadjuvant chemotherapy (NAC). Materials and Methods This prospective study included 41 patients with breast cancer. CEUS was performed before and after the first cycle of NAC. TIC parameters were analyzed for different regions of interest (ROIs). ROI 1 targeted the hotspot area of greatest enhancement, ROI 2 delineated the area of hyperenhancement, ROI 3 included the entire tumor on grayscale ultrasound, and ROI 4 encircled the normal parenchyma. The TIC perfusion values for ROI 1, 2, and 3 were divided by the ROI 4 value. Results 11 (26.8 %) of the 41 patients showed a good response (Miller-Payne score 4 or 5) and 30 (73.2 %) showed a minor response (Miller-Payne score 1, 2, or 3). There were significant differences in the wash-out area under the curve, the wash-in and wash-out areas under the curve on ROI 1/4 after the first cycle of NAC, pre-NAC mean transit time local (mTTl) on ROI 2/4, and pre-NAC mTTl on ROI 3/4 between good and minor responders (area under the receiver-operating characteristic curve > 0.70, p < 0.05). Conclusion Some TIC parameters obtained by CEUS may allow prediction of the response of breast cancer to NAC at a very early time point.

show abstract

Quantitative Analysis of Contrast-Enhanced Ultrasound Imaging in Invasive Breast Cancer: A Novel Technique to Obtain Histopathologic Information of Microvessel Density

Cited by 25 publications

References 38 publications

Prediction of neoadjuvant chemotherapy response using diffuse optical spectroscopy in breast cancer

Prediction of neoadjuvant chemotherapy response using diffuse optical spectroscopy in breast cancer

Clinical evaluation of vascular normalization induced by recombinant human endostatin in nasopharyngeal carcinoma via dynamic contrast-enhanced ultrasonography

Contrast-Enhanced Ultrasound for Early Prediction of Response of Breast Cancer to Neoadjuvant Chemotherapy

Contact Info

Product

Resources

About