Quantitative Analysis of Active Pharmaceutical Ingredients (APIs) Using a Potentiometric Electronic Tongue in a SIA Flow System

Wesoły, Małgorzata; Cetó, Xavier; Valle, Manel del; Ciosek, Patrycja; Wróblewski, Wojciech

doi:10.1002/elan.201500407

Cited by 22 publications

(16 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[33][34][35] Recently, ISEs have been often used as a detector of SIA. [36][37][38][39][40][41][42][43] An ideal automated analytical method for the determination of ASs will be developed using a combination of advantages of the SIA system and microfluidic chips with embedded miniaturized ISEs. Generally, AS in environmental water samples is not determined using AS-ISEs because lower limit of Nernstian response of reported AS-ISEs is order of approximately 10…”

Section: ¹1mentioning

confidence: 99%

Sequential Injection Analysis of Anionic Surfactants Using On-line Preconcentration Technique and a Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode as a Detector

Masadome

Arai

2018

Electrochemistry

View full text Add to dashboard Cite

A sequential injection analysis (SIA) system with on-line preconcentration technique using a microfluidic chip with an embedded anionic surfactant ion-selective electrode (AS-ISE) as a detector, was developed for the determination of anionic surfactants. Under the SIA system with no on-line preconcentration technique, the AS-ISE in the SIA system showed a linear relationship between peak heights and logarithmic concentrations of AS ion such as dodecylbenzene sulfonate (DBS) ion with a Nernstian slope of 60.4 mV decade −1 in a concentration range from 3.0 × 10 −6 to 1.0 × 10 −3 mol dm. For the determination of trace levels of ASs, on-line preconcentration technique with solid-phase extraction process was incorporated into the SIA system. By using the on-line preconcentration technique in the SIA system, DBS ion in a concentration range from 1.0 × 10 −7 to 3.0 × 10 −6 mol dm −3 was successfully determined. The recovery for DBS ion added to river water samples was ca. 91-97% using on-line preconcentration technique in the SIA system. The result shows that the present SIA system with the on-line preconcentration technique can be applicable to the determination of the level of AS ion in river and tap water samples.

show abstract

Section: ¹1mentioning

confidence: 99%

Sequential Injection Analysis of Anionic Surfactants Using On-line Preconcentration Technique and a Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode as a Detector

Masadome

Arai

2018

Electrochemistry

View full text Add to dashboard Cite

show abstract

“…Such a device was utilized previously for the studies of different samples: discrimination between various formulations based on caffeine citrate (19), microencapsulated ibuprofen and roxithromycin (20,21,32) and for the analysis of acetaminophen, ascorbic acid and acetylsalicylic acid in a mixture (33). Final chemical images for appropriate time points were presented on 2D-PCA plots (Figs.…”

Section: Taste Masking Evaluation Of Microparticles Obtained With Cetmentioning

confidence: 99%

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

et al. 2017

View full text Add to dashboard Cite

Taste of a pharmaceutical formulation is an important parameter for the effectiveness of pharmacotherapy. Cetirizine dihydrochloride (CET) is a second-generation antihistamine that is commonly administered in allergy treatment. CET is characterized by extremely bitter taste and it is a great challenge to successfully mask its taste; therefore the goal of this work was to formulate and characterize the microparticles obtained by the spray drying method with CET and poly(butyl methacrylate-co-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 copolymer (Eudragit E PO) as a barrier coating. Assessment of taste masking by the electronic tongue has revealed that designed formulations created an effective taste masking barrier. Taste masking effect was also confirmed by the in vivo model and the in vitro release profile of CET. Obtained data have shown that microparticles with a drug/polymer ratio (0.5:1) are promising CET carriers with efficient taste masking potential and might be further used in designing orodispersible dosage forms with CET.Keywords: taste masking, electronic tongue, cetirizine dihydrochloride, microparticles, methacrylate copolymer, spray drying Unacceptable taste is an important problem encountered in the designing of new dosage forms. Taste masking of drug substances has been continuously changing with emerging techniques and new excipients (1-7). Taste masking can be carried out by various methods, depending on the therapeutic agent and dosage form. One of the simplest taste masking methods is addition of flavors, sweeteners and effervescent agents, but it is not always effective. In recent years, methods creating a physical barrier between active ingredients and taste buds have been developed for taste masking. One of them is spray drying, a relatively simple and convenient technology for the preparation of microparticles (8)(9)(10)(11)

show abstract

“…Research on electronic tongues conducted in our group has led so far to the development of many multisensor systems dedicated to quality control in the food industry (Ciosek and Wróblewski, 2011;Kutyla-Olesiuk et al, 2013a), environmental monitoring (Kutyla-Olesiuk et al, 2013b), pharmaceutical analysis (Wesoły et al, 2016;Wesoły et al, 2017), medical diagnostics (Jańczyk et al, 2013) and biotech industry . Various systems adapted to bioanalytical applications, where small volume samples are usually considered, were developed: flow-through potentiometric sensor array , planar integrated sensor array (Ciosek and Kraszewska, 2009), flowthrough microsystem with integrated sensor array (Witkowska Nery et al, 2014).…”

Section: Fig 1 Electronic Tongue Set-up: Sensor Array (A) With a Samentioning

confidence: 99%

“…Various systems adapted to bioanalytical applications, where small volume samples are usually considered, were developed: flow-through potentiometric sensor array , planar integrated sensor array (Ciosek and Kraszewska, 2009), flowthrough microsystem with integrated sensor array (Witkowska Nery et al, 2014). They were used in various modes of measuremetns: batch (Ciosek and Wróblewski, 2011;Wesoły et al, 2017), flow-through (Kutyla-Olesiuk et al, 2013b, Witkowska Nery et al, 2014, flow injection and sequential injection (Wesoły et al, 2016) analysis. It was shown, that the developed electronic tongues were capable of effective classification of samples, as well as semi-quantitative and quantitative analysis.…”

Section: Fig 1 Electronic Tongue Set-up: Sensor Array (A) With a Samentioning

confidence: 99%

Application of various types of coatings in food packaging materials: Sensorial assessment and health safety

Nowacka¹,

Mika²,

Wiktor³

et al. 2017

J Process Energy Agric

View full text Add to dashboard Cite

show abstract

Quantitative Analysis of Active Pharmaceutical Ingredients (APIs) Using a Potentiometric Electronic Tongue in a SIA Flow System

Cited by 22 publications

References 36 publications

Sequential Injection Analysis of Anionic Surfactants Using On-line Preconcentration Technique and a Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode as a Detector

Sequential Injection Analysis of Anionic Surfactants Using On-line Preconcentration Technique and a Microfluidic Polymer Chip with an Embedded Ion-Selective Electrode as a Detector

Characterization and taste masking evaluation of microparticles with cetirizine dihydrochloride and methacrylate-based copolymer obtained by spray drying

Application of various types of coatings in food packaging materials: Sensorial assessment and health safety

Contact Info

Product

Resources

About